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Nitinol (NiTi shape-memory alloy) is an interesting candidate in various medical applications like dental, orthopedic, and cardiovascular devices, owing to its unique mechanical behaviors and proper biocompatibility. The aim of this work is…

Biological Physics · Physics 2026-01-29 M. Moradi , E. Salahinejad , E. Sharifi , L. Tayebi

Domain decomposition has been shown to be a computationally efficient distributed method for solving large scale entropic optimal transport problems. However, a naive implementation of the algorithm can freeze in the limit of very fine…

Numerical Analysis · Mathematics 2025-03-28 Ismael Medina , Bernhard Schmitzer

Parkinson's disease (PD) is one of the major public health problems in the world. It is a well-known fact that around one million people suffer from Parkinson's disease in the United States whereas the number of people suffering from…

Machine Learning · Computer Science 2016-10-27 Kamal Nayan Reddy Challa , Venkata Sasank Pagolu , Ganapati Panda , Babita Majhi

Self-supervised learning in healthcare has largely relied on invariance-based objectives, which maximize similarity between different views of the same patient. While effective for static anatomy, this paradigm is fundamentally misaligned…

Machine Learning · Computer Science 2026-04-27 Jose Geraldo Fernandes , Luiz Facury , Pedro Robles Dutenhefner , Wagner Meira

Deep Brain Stimulation (DBS) stands as an effective intervention for alleviating the motor symptoms of Parkinson's disease (PD). Traditional commercial DBS devices are only able to deliver fixed-frequency periodic pulses to the basal…

Machine Learning · Computer Science 2024-03-12 Hao-Lun Hsu , Qitong Gao , Miroslav Pajic

Physics-informed diffusion models typically enforce PDE constraints only on final outputs, leaving intermediate representations unconstrained and prone to shortcut learning under shifted boundary conditions. We introduce **REPA-P**, a…

Machine Learning · Computer Science 2026-05-21 Haozhe Jia , Pengyu Yin , Wenshuo Chen , Shaofeng Liang , Lei Wang , Bowen Tian , Xiucheng Wang , Nanqian Jia , Yutao Yue

Suppression of excessively synchronous beta-band oscillatory activity in the brain is believed to suppress hypokinetic motor symptoms of Parkinson's disease. Recently, a lot of interest has been devoted to desynchronizing delayed feedback…

Neurons and Cognition · Quantitative Biology 2013-03-05 Andrey Dovzhenok , Choongseok Park , Robert M. Worth , Leonid L. Rubchinsky

Parkinson's disease (PD) is a progressive disorder in which symptom burden and functional impairment evolve over time, making severity staging essential for clinical monitoring and treatment planning. However, many computational studies…

Machine Learning · Computer Science 2026-04-21 Md Mezbahul Islam , John Michael Templeton , Christian Poellabauer , Ananda Mohan Mondal

Running title: Frontoparietal anodal tDCS reduces ketamine-induced oscillopathies.Abstract: During the prodromal phase of schizophrenia with its complex and insidious clinical picture, electroencephalographic recordings detect widespread…

Neurons and Cognition · Quantitative Biology 2020-10-14 Caroline Lahogue , Didier Pinault

Monte Carlo (MC) simulations provide gold-standard accuracy for carbon ion therapy dose calculations but are computationally intensive. Analytical pencil beam algorithms offer speed but reduced accuracy in heterogeneous tissues. We…

The transport properties of a disordered two-dimensional (2D) honeycomb lattice are examined numerically using the spectral approach to the quantum percolation problem, characterized by an Anderson-type Hamiltonian. In our simulations,…

Computational Physics · Physics 2019-02-01 E G Kostadinova , C D Liaw , A S Hering , A Cameron , F Guyton , L S Matthews , T W Hyde

Mechanisms for non-invasive target drug delivery using microbubbles and ultrasound have attracted growing interest. Microbubbles can be loaded with a therapeutic payload and tracked via ultrasound imaging to selectively release their…

Medical Physics · Physics 2019-02-07 S. Harput , L. Nie , D. M. J. Cowell , T. Carpenter , B. Raiton , J. McLaughlan , S. Freear

We propose a bound-preserving (BP) Point-Average-Moment PolynomiAl-interpreted (PAMPA) scheme by blending third-order and first-order constructions. The originality of the present construction is that it does not need any explicit…

Numerical Analysis · Mathematics 2025-06-17 Rémi Abgrall , Miaosen Jiao , Yongle Liu , Kailiang Wu

Direct Preference Optimisation (DPO) has emerged as a powerful method for aligning Large Language Models (LLMs) with human preferences, offering a stable and efficient alternative to approaches that use Reinforcement learning via Human…

Artificial Intelligence · Computer Science 2025-05-06 Sarvesh Shashidhar , Ritik , Nachiketa Patil , Suraj Racha , Ganesh Ramakrishnan

Alzheimer's disease (AD) is a chronic neurodegenerative condition responsible for most cases of dementia and considered as one of the greatest challenges for neuroscience in this century. Early Ad signs are usually mistaken for normal…

Neurons and Cognition · Quantitative Biology 2021-02-08 Juan A. Arias , Carmen Cadarso-Suárez , Pablo Aguiar-Fernández

Objective: The artificial pancreas (AP) has shown promising potential in achieving closed-loop glucose control for individuals with type 1 diabetes mellitus (T1DM). However, designing an effective control policy for the AP remains…

Artificial Intelligence · Computer Science 2023-07-17 Wenzhou Lv , Tianyu Wu , Luolin Xiong , Liang Wu , Jian Zhou , Yang Tang , Feng Qian

There is an increasing interest in studying the neural interaction mechanisms behind patterns of cognitive brain activity. This paper proposes a new approach to infer such interaction mechanisms from electroencephalographic (EEG) data using…

Information Theory · Computer Science 2014-04-03 Xu Chen , Zeeshan Syed , Alfred Hero

Electroporation method is a useful tool for delivering drugs into various diseased tissues in the human body. As a result of an applied electric field, drug particles enter the intracellular compartment through the temporarily permeabilized…

Tissues and Organs · Quantitative Biology 2022-08-10 Nilay Mondal , K. S. Yadav , D. C. Dalal

Nanoencapsulation has become a widespread technique to improve the bioavailability of bioactive compounds like lycopene. Consumption of lycopene rich foods is effective in preventing cancer, diabetes, and cardiovascular diseases due to its…

Biomolecules · Quantitative Biology 2023-01-30 Mohammad Anwar Ul Alam , Lamin Kassama

Peritoneal dialysis (PD) is becoming more popular as a result of a rising interest in home dialysis, lower intrusion in social life and longer preservation of residual kidney function. However, PD has several important drawbacks: small…

Quantitative Methods · Quantitative Biology 2025-02-20 Sangita Swapnasrita , Joost C de Vries , Carl M Öberg , Aurélie MF Carlier , Karin GF Gerritsen
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