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In living cells, biochemical reactions are catalyzed by specific enzymes and connect to one another by sharing substrates and products, forming complex networks. In our previous studies, we established a framework determining the responses…

Molecular Networks · Quantitative Biology 2017-09-06 Takashi Okada , Atsushi Mochizuki

Motivation: A Chemical Reaction Network (CRN) is a set of chemical reactions, which can be very complex and difficult to analyze. Indeed, dynamical properties of CRNs can be described by a set of non-linear differential equations that…

Computational Engineering, Finance, and Science · Computer Science 2021-07-02 Lucia Nasti , Roberta Gori , Paolo Milazzo , Federico Poloni

Exploring the effects a chemical compound has on a species takes a considerable experimental effort. Appropriate methods for estimating and suggesting new effects can dramatically reduce the work needed to be done by a laboratory. In this…

Artificial Intelligence · Computer Science 2019-11-12 Erik Bryhn Myklebust , Ernesto Jimenez-Ruiz , Jiaoyan Chen , Raoul Wolf , Knut Erik Tollefsen

Chemical kinetic mechanisms can be represented by sets of elementary reactions that are easily translated into mathematical terms using physicochemical relationships. The schematic representation of reactions captures the interactions…

Optimization and Control · Mathematics 2019-02-12 Farshad Harirchi , Doohyun Kim , Omar A. Khalil , Sijia Liu , Paolo Elvati , Angela Violi , Alfred O. Hero

Real-world scenarios demand reasoning about process, more than final outcome prediction, to discover latent causal chains and better understand complex systems. It requires the learning algorithms to offer both accurate predictions and…

Artificial Intelligence · Computer Science 2019-01-09 Xiaoran Xu , Songpeng Zu , Chengliang Gao , Yuan Zhang , Wei Feng

Empathetic response generation aims to comprehend the user emotion and then respond to it appropriately. Most existing works merely focus on what the emotion is and ignore how the emotion is evoked, thus weakening the capacity of the model…

Computation and Language · Computer Science 2021-10-12 Jiashuo Wang , Wenjie LI , Peiqin Lin , Feiteng Mu

As of February 2016 Facebook allows users to express their experienced emotions about a post by using five so-called `reactions'. This research paper proposes and evaluates alternative methods for predicting these reactions to user posts on…

Artificial Intelligence · Computer Science 2017-12-12 Florian Krebs , Bruno Lubascher , Tobias Moers , Pieter Schaap , Gerasimos Spanakis

Learned knowledge graph representations supporting robots contain a wealth of domain knowledge that drives robot behavior. However, there does not exist an inference reconciliation framework that expresses how a knowledge graph…

Artificial Intelligence · Computer Science 2022-05-05 Angel Daruna , Devleena Das , Sonia Chernova

Recent developments in computational chemistry facilitate the automated quantum chemical exploration of chemical reaction networks for the in-silico prediction of synthesis pathways, yield, and selectivity. However, the underlying quantum…

Chemical Physics · Physics 2025-10-22 Marco Eckhoff , Markus Reiher

We present a model of sense-making that greatly facilitates the collaboration between an intelligent analyst and a knowledge-based agent. It is a general model grounded in the science of evidence and the scientific method of hypothesis…

Artificial Intelligence · Computer Science 2021-11-09 Gheorghe Tecuci , Dorin Marcu , Louis Kaiser , Mihai Boicu

Over the past decade, Artificial Intelligence has significantly advanced, mostly driven by large-scale neural approaches. However, in the chemical process industry, where safety is critical, these methods are often unsuitable due to their…

Machine Learning · Computer Science 2026-03-24 Julien Amblard , Niklas Groll , Matthew Tait , Mark Law , Gürkan Sin , Alessandra Russo

Neural networks have proven to be effective at solving machine learning tasks but it is unclear whether they learn any relevant causal relationships, while their black-box nature makes it difficult for modellers to understand and debug…

Machine Learning · Computer Science 2023-08-02 Fabrizio Russo , Francesca Toni

Atom tracing is essential for understanding the fate of labeled atoms in biochemical reaction networks, yet existing computational methods either simplify label correlations or suffer from combinatorial explosion. We introduce a…

Molecular Networks · Quantitative Biology 2025-12-12 Marcel Friedrichs , Daniel Merkle

An algorithm is given in this paper for the computation of dynamically equivalent weakly reversible realizations with the maximal number of reactions, for chemical reaction networks (CRNs) with mass action kinetics. The original problem…

Dynamical Systems · Mathematics 2011-07-05 Gabor Szederkenyi , Katalin M. Hangos , Zsolt Tuza

One approach to studying the system-wide organization of biochemistry is to use statistical graph theory. Even in such a heavily simplified method, which disregards most of the dynamic aspects of biochemistry, one is faced with fundamental…

Molecular Networks · Quantitative Biology 2010-08-17 Petter Holme , Mikael Huss

Users interacting with voice assistants today need to phrase their requests in a very specific manner to elicit an appropriate response. This limits the user experience, and is partly due to the lack of reasoning capabilities of dialogue…

Computation and Language · Computer Science 2022-03-22 Yi-Lin Tuan , Sajjad Beygi , Maryam Fazel-Zarandi , Qiaozi Gao , Alessandra Cervone , William Yang Wang

Graph neural networks are widely used to learn global representations of graphs, which are then used for regression or classification tasks. Typically, the graphs in such data sets are connected, i.e. each training sample consists of a…

Computational Engineering, Finance, and Science · Computer Science 2022-11-01 Chen Shao , Zhou Chen , Pascal Friederich

Bio-oil molecule assessment is essential for the sustainable development of chemicals and transportation fuels. These oxygenated molecules have adequate carbon, hydrogen, and oxygen atoms that can be used for developing new value-added…

Chemical Physics · Physics 2020-01-10 Romit Maulik , Rajeev Surendran Array , Prasanna Balaprakash

A numerically effective procedure for determining weakly reversible chemical reaction networks that are linearly conjugate to a known reaction network is proposed in this paper. The method is based on translating the structural and…

Dynamical Systems · Mathematics 2014-07-15 Matthew D. Johnston , David Siegel , Gábor Szederkényi

Reaction systems are discrete dynamical systems inspired by bio-chemical processes, whose dynamical behaviour is expressed by set-theoretic operations on finite sets. Reaction systems thus provide a description of bio-chemical phenomena…

Formal Languages and Automata Theory · Computer Science 2020-08-05 Alberto Dennunzio , Enrico Formenti , Luca Manzoni , Antonio E. Porreca
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