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False discovery rate (FDR) control in structured hypotheses testing is an important topic in simultaneous inference. Most existing methods that aim to utilize group structure among hypotheses either employ the groupwise mixture model or…

Methodology · Statistics 2019-08-16 Xiongzhi Chen , Sanat K. Sarkar

The original problem of group testing consists in the identification of defective items in a collection, by applying tests on groups of items that detect the presence of at least one defective item in the group. The aim is then to identify…

Applications · Statistics 2021-06-10 Emilien Joly , Bastien Mallein

As closed-loop materials discovery systems scale to produce millions of candidate compounds, the credibility of the novelty they reward becomes a critical concern. Novelty is commonly assessed against databases of ordered crystal…

Materials Science · Physics 2026-04-24 Shuya Yamazaki , Yuyao Huang , Martin Hoffmann Petersen , Wei Nong , Kedar Hippalgaonkar

We propose and study a general method for construction of consistent statistical tests on the basis of possibly indirect, corrupted, or partially available observations. The class of tests devised in the paper contains Neyman's smooth…

Statistics Theory · Mathematics 2017-09-22 Mikhail Langovoy

Bayesian experimental design (BED) for complex physical systems is often limited by the nested inference required to estimate the expected information gain (EIG) or its gradients. Each outer sample induces a different posterior, creating a…

Information Theory · Computer Science 2026-04-21 Huchen Yang , Xinghao Dong , Jinlong Wu

The group testing problem is concerned with identifying a small set of $k$ infected individuals in a large population of $n$ people. At our disposal is a testing scheme that can test groups of individuals. A test comes back positive if and…

Information Theory · Computer Science 2021-03-25 Oliver Gebhard , Philipp Loick

We describe a new family of coupling designs, extending the basic principle of stratified randomization to experiments with continuous, constrained multivariate, text/image and other irregular treatment spaces. Our approach is to first…

Econometrics · Economics 2026-04-14 Max Cytrynbaum , Fredrik Sävje

Group testing can help maintain a widespread testing program using fewer resources amid a pandemic. In group testing, we are given $n$ samples, one per individual. These samples are arranged into $m < n$ pooled samples, where each pool is…

Information Theory · Computer Science 2022-01-20 Ritesh Goenka , Shu-Jie Cao , Chau-Wai Wong , Ajit Rajwade , Dror Baron

Software testing involves identifying the test cases whichdiscover errors in the program. However, exhaustive testing ofsoftware is very time consuming. In this paper, a technique isproposed to prioritize test case scenarios by identifying…

Software Engineering · Computer Science 2014-10-21 Chayanika Sharma , Sangeeta Sabharwal , Ritu Sibal

We investigate the optimal design of experimental studies that have pre-treatment outcome data available. The average treatment effect is estimated as the difference between the weighted average outcomes of the treated and control units. A…

The development of large, software-intensive systems is a complex undertaking that we generally tackle by a divide and conquer strategy. Companies thereby face the challenge of coordinating individual aspects of software development, in…

Software Engineering · Computer Science 2023-08-16 Michael Unterkalmsteiner , Tony Gorschek , Robert Feldt , Eriks Klotins

Group sequential designs (GSDs) are well established and the most commonly used adaptive design in confirmatory clinical trials with interim analyses. However, they remain underutilised, and their implementation involves unique theoretical…

Methodology · Statistics 2025-09-09 Zhangyi He , Suzie Cro , Laurent Billot

Deep neural networks have shown impressive performance for image-based disease detection. Performance is commonly evaluated through clinical validation on independent test sets to demonstrate clinically acceptable accuracy. Reporting good…

Image and Video Processing · Electrical Eng. & Systems 2023-09-18 Mobarakol Islam , Zeju Li , Ben Glocker

Breakthroughs in cancer biology have defined new research programs emphasizing the development of therapies that target specific pathways in tumor cells. Innovations in clinical trial design have followed with master protocols defined by…

Methodology · Statistics 2020-07-09 Alexander M. Kaizer , Joseph S. Koopmeiners , Nan Chen , Brian P. Hobbs

The problem of robust binary hypothesis testing is studied. Under both hypotheses, the data-generating distributions are assumed to belong to uncertainty sets constructed through moments; in particular, the sets contain distributions whose…

Statistics Theory · Mathematics 2024-01-09 Akshayaa Magesh , Zhongchang Sun , Venugopal V. Veeravalli , Shaofeng Zou

Group-formation experiments, in which experimental units are randomly assigned to groups, are a powerful tool for studying peer effects in the social sciences. Existing design and analysis approaches allow researchers to draw inference from…

Methodology · Statistics 2021-03-02 Hui Xu , Guillaume Basse

Group testing is one of the fundamental problems in coding theory and combinatorics in which one is to identify a subset of contaminated items from a given ground set. There has been renewed interest in group testing recently due to its…

Information Theory · Computer Science 2022-02-11 Mira Gonen , Michael Langberg , Alex Sprintson

In a group sequential clinical trial, accumulated data are analysed at numerous time-points in order to allow early decisions about a hypothesis of interest. These designs have historically been recommended for their ethical, administrative…

Computation · Statistics 2017-11-29 Michael Grayling , James Wason , Adrian Mander

We consider nonadaptive group testing where each item is placed in a constant number of tests. The tests are chosen uniformly at random with replacement, so the testing matrix has (almost) constant column weights. We show that performance…

Information Theory · Computer Science 2016-08-23 Matthew Aldridge , Oliver Johnson , Jonathan Scarlett

In group testing, the task is to determine the distinguished members of a set of objects L by asking subset queries of the form ``does the subset Q of L contain a distinguished object?'' The primary biological application of group testing…

Combinatorics · Mathematics 2008-02-03 Emanuel Knill , S. Muthukrishnan