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Multiple imputation (MI) has been widely applied to missing value problems in biomedical, social and econometric research, in order to avoid improper inference in the downstream data analysis. In the presence of high-dimensional data,…

Methodology · Statistics 2023-05-04 Zhiqi Bu , Zongyu Dai , Yiliang Zhang , Qi Long

The studies of large-scale, high-dimensional data in fields such as genomics and neuroscience have injected new insights into science. Yet, despite advances, they are confronting several challenges, often simultaneously: lack of…

Methodology · Statistics 2024-01-01 Julien Bodelet , Guillaume Blanc , Jiajun Shan , Graciela Muniz Terrera , Oliver Y. Chen

Many machine learning applications such as in vision, biology and social networking deal with data in high dimensions. Feature selection is typically employed to select a subset of features which im- proves generalization accuracy as well…

Machine Learning · Computer Science 2016-06-15 Yamuna Prasad , Dinesh Khandelwal , K. K. Biswas

In recent years the importance of finding a meaningful pattern from huge datasets has become more challenging. Data miners try to adopt innovative methods to face this problem by applying feature selection methods. In this paper we propose…

Machine Learning · Computer Science 2014-03-11 Mehdi Naseriparsa , Amir-masoud Bidgoli , Touraj Varaee

Feature selection aims to identify the most pattern-discriminative feature subset. In prior literature, filter (e.g., backward elimination) and embedded (e.g., Lasso) methods have hyperparameters (e.g., top-K, score thresholding) and tie to…

Machine Learning · Computer Science 2024-03-07 Wangyang Ying , Dongjie Wang , Haifeng Chen , Yanjie Fu

Understanding and extracting the patterns of microscopy images has been a major challenge in the biomedical field. Although trained scientists can locate the proteins of interest within a human cell, this procedure is not efficient and…

Computer Vision and Pattern Recognition · Computer Science 2020-06-09 Hanke Chen

Model selection is an indispensable part of data analysis dealing very frequently with fitting and prediction purposes. In this paper, we tackle the problem of model selection in a general linear regression where the parameter matrix…

Signal Processing · Electrical Eng. & Systems 2022-09-19 Prakash B. Gohain , Magnus Jansson

Prediction of patient survival using high-dimensional multi-omics data requires systematic feature selection methods that ensure predictive performance, sparsity, and reliability for prognostic biomarker discovery. We developed a hybrid…

Genomics · Quantitative Biology 2026-04-15 John Zobolas , Anne-Marie George , Alberto López , Sebastian Fischer , Marc Becker , Tero Aittokallio

Liquid chromatography with tandem mass spectrometry (LC-MS/MS) based proteomics is a well-established research field with major applications such as identification of disease biomarkers, drug discovery, drug design and development. In…

Quantitative Methods · Quantitative Biology 2018-01-08 Fatema Tuz Zohora , Ngoc Hieu Tran , Xianglilan Zhang , Lei Xin , Baozhen Shan , Ming Li

We present a nonparametric method for selecting informative features in high-dimensional clustering problems. We start with a screening step that uses a test for multimodality. Then we apply kernel density estimation and mode clustering to…

Statistics Theory · Mathematics 2014-06-10 Larry Wasserman , Martin Azizyan , Aarti Singh

Although much progress has been made in classification with high-dimensional features \citep{Fan_Fan:2008, JGuo:2010, CaiSun:2014, PRXu:2014}, classification with ultrahigh-dimensional features, wherein the features much outnumber the…

Machine Learning · Statistics 2016-11-14 Yanming Li , Hyokyoung Hong , Jian Kang , Kevin He , Ji Zhu , Yi Li

Feature selection is a combinatorial optimization problem that is NP-hard. Conventional approaches often employ heuristic or greedy strategies, which are prone to premature convergence and may fail to capture subtle yet informative…

Machine Learning · Computer Science 2025-10-22 Yusi Fan , Tian Wang , Zhiying Yan , Chang Liu , Qiong Zhou , Qi Lu , Zhehao Guo , Ziqi Deng , Wenyu Zhu , Ruochi Zhang , Fengfeng Zhou

A ubiquitous feature of data of our era is their extra-large sizes and dimensions. Analyzing such high-dimensional data poses significant challenges, since the feature dimension is often much larger than the sample size. This thesis…

Statistics Theory · Mathematics 2025-09-11 Kai Yang

Nonparametric feature selection in high-dimensional data is an important and challenging problem in statistics and machine learning fields. Most of the existing methods for feature selection focus on parametric or additive models which may…

Methodology · Statistics 2021-03-31 Hang Yu , Yuanjia Wang , Donglin Zeng

Over the past decades, statisticians and machine-learning researchers have developed literally thousands of new tools for the reduction of high-dimensional data in order to identify the variables most responsible for a particular trait.…

Machine Learning · Statistics 2012-05-31 Chamont Wang , Jana Gevertz , Chaur-Chin Chen , Leonardo Auslender

This study introduces a novel unsupervised medical image feature extraction method that employs spatial stratification techniques. An objective function based on weight is proposed to achieve the purpose of fast image recognition. The…

Image and Video Processing · Electrical Eng. & Systems 2024-06-28 Qishi Zhan , Dan Sun , Erdi Gao , Yuhan Ma , Yaxin Liang , Haowei Yang

Many computer vision and medical imaging problems are faced with learning from large-scale datasets, with millions of observations and features. In this paper we propose a novel efficient learning scheme that tightens a sparsity constraint…

Machine Learning · Statistics 2017-02-07 Adrian Barbu , Yiyuan She , Liangjing Ding , Gary Gramajo

For various applications, the relations between the dependent and independent variables are highly nonlinear. Consequently, for large scale complex problems, neural networks and regression trees are commonly preferred over linear models…

Machine Learning · Computer Science 2017-05-23 Samet Oymak , Mehrdad Mahdavi , Jiasi Chen

A supervised feature selection method selects an appropriate but concise set of features to differentiate classes, which is highly expensive for large-scale datasets. Therefore, feature selection should aim at both minimizing the number of…

Machine Learning · Computer Science 2024-02-21 Sevil Zanjani Miyandoab , Shahryar Rahnamayan , Azam Asilian Bidgoli

The Classification on high-dimension low-sample-size data (HDLSS) is a challenging problem and it is common to have class-imbalanced data in most application fields. We term this as Imbalanced HDLSS (IHDLSS). Recent theoretical results…

Machine Learning · Computer Science 2022-06-09 Liran Shen , Meng Joo Er , Qingbo Yin