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This is the manuscript of the chapter for a planned Handbook of Mathematical Methods in Imaging that surveys the mathematical models, problems, and algorithms of the Thermoacoustic (TAT) and Photoacoustic (PAT) Tomography. TAT and PAT…

Analysis of PDEs · Mathematics 2011-10-04 Peter Kuchment , Leonid Kunyansky

The goal of quantitative photoacoustic tomography is to determine optical and acoustical material properties from initial pressure maps as obtained, for instance, from photoacoustic imaging. The most relevant parameters are absorption,…

Analysis of PDEs · Mathematics 2015-09-21 Wolf Naetar , Otmar Scherzer

We discuss how two-photon absorption (TPA) of squeezed and coherent states of light can be detected in measurements of the transmitted light fields. Such measurements typically suffer from competing loss mechanisms such as experimental…

Quantum Physics · Physics 2022-05-24 Shahram Panahiyan , Carlos Sánchez Muñoz , Maria V. Chekhova , Frank Schlawin

Motion, e.g., due to patient movement or improper device calibration, is inevitable in many imaging modalities such as photoacoustic tomography (PAT) by a rotating system and can lead to undesirable motion artifacts in image…

Numerical Analysis · Mathematics 2016-09-28 Julianne Chung , Linh Nguyen

Quantitative image reconstruction in photoacoustic tomography requires the solution of a coupled physics inverse problem involvier light transport and acoustic wave propagation. In this paper we address this issue employing the radiative…

Analysis of PDEs · Mathematics 2017-02-16 Markus Haltmeier , Lukas Neumann , Linh V. Nguyen , Simon Rabanser

The attenuation of ultrasound waves in photoacoustic and thermoacoustic imaging presents an important drawback in the applicability of these modalities. This issue has been addressed previously in the applied and theoretical literature, and…

Analysis of PDEs · Mathematics 2021-09-15 Benjamin Palacios

Photoacoustic imaging is an emerging imaging modality that is based upon the photoacoustic effect. In photoacoustic tomography (PAT), the induced acoustic pressure waves are measured by an array of detectors and used to reconstruct an image…

Computer Vision and Pattern Recognition · Computer Science 2019-04-26 Steven Guan , Amir Khan , Siddhartha Sikdar , Parag V. Chitnis

The development of efficient and accurate image reconstruction algorithms is one of the cornerstones of computed tomography. Existing algorithms for quantitative photoacoustic tomography currently operate in a two-stage procedure: First an…

Analysis of PDEs · Mathematics 2015-05-20 Markus Haltmeier , Lukas Neumann , Simon Rabanser

Photoacoustic computed tomography (PACT) is an emerging computed imaging modality that exploits optical contrast and ultrasonic detection principles to form images of the absorbed optical energy density within tissue. If the object…

Medical Physics · Physics 2017-09-08 Joemini Poudel , Thomas P. Matthews , Lei Li , Mark A. Anastasio , Lihong V. Wang

While in standard photoacoustic imaging the propagation of sound waves is modeled by the standard wave equation, our approach is based on a generalized wave equation with variable sound speed and material density, respectively. In this…

Analysis of PDEs · Mathematics 2018-04-18 Alexander Beigl , Peter Elbau , Kamran Sadiq , Otmar Scherzer

Photoacoustic tomography leverages ultrasound's deep tissue penetration to retrieve optical absorption contrast well beyond the optical diffusion limit. Conventional photoacoustic systems rely on externally delivered light and are therefore…

Optics · Physics 2026-01-06 David C. Garrett , Lihong V. Wang

A framework for reconstruction of optical diffusion and absorption coefficients in quantitative photoacoustic tomography is presented. This framework is based on a Tikhonov-type functional with a regularization term promoting sparsity of…

Optimization and Control · Mathematics 2024-02-01 Anwesa Dey , Alfio Borzi , Souvik Roy

Photo-acoustic spectroscopy (PAS) is one of the most sensitive non-destructive analysis techniques for gases, fluids and solids. It can operate background-free at any wavelength and is applicable to microscopic and even non-transparent…

Photoacoustic tomography (PAT) is an emerging imaging modality that combines the complementary strengths of optical contrast and ultrasonic resolution. A central task is image reconstruction, where measured acoustic signals are used to…

Computer Vision and Pattern Recognition · Computer Science 2026-04-20 Markus Haltmeier , Nadja Gruber , Gyeongha Hwang

In most photoacoustic (PA) measurements, variations in speed-of-sound (SOS) of the subject are neglected under the assumption of acoustic homogeneity. Biological tissue with spatially heterogeneous SOS cannot be accurately reconstructed…

In this article, we study several reconstruction methods for the inverse source problem of photoacoustic tomography (PAT) with spatially variable sound speed and damping. The backbone of these methods is the adjoint operators, which we…

Analysis of PDEs · Mathematics 2018-08-21 Linh V. Nguyen , Markus Haltmeier

Photoacoustic tomography is a hybrid biomedical technology, which combines the advantages of acoustic and optical imaging. However, for the conventional image reconstruction method, the image quality is affected obviously by artifacts under…

Image and Video Processing · Electrical Eng. & Systems 2024-06-26 Bowei Yao , Yi Zeng , Haizhao Dai , Qing Wu , Youshen Xiao , Fei Gao , Yuyao Zhang , Jingyi Yu , Xiran Cai

Photoacoustic tomography is an emerging medical imaging technology whose primary aim is to map the high-contrast optical properties of biological tissues by leveraging high-resolution ultrasound measurements. Mathematically, this can be…

Analysis of PDEs · Mathematics 2025-02-14 Alessandro Felisi

A method for photoacoustic tomography is presented that uses circular integrals of the acoustic wave for the reconstruction of a three-dimensional image. Image reconstruction is a two-step process: In the first step data from a stack of…

Numerical Analysis · Mathematics 2009-12-06 G. Zangerl , O. Scherzer , M. Haltmeier

We investigate the inverse problem of recovering an initial source for the wave equation with fractional attenuation, motivated by photoacoustic tomography (PAT). The attenuation is modeled by a Caputo fractional derivative of order…

Analysis of PDEs · Mathematics 2025-10-10 Sebastian Acosta , Benjamin Palacios