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Inference of gene regulatory network from expression data is a challenging task. Many methods have been developed to this purpose but a comprehensive evaluation that covers unsupervised, semi-supervised and supervised methods, and provides…

Molecular Networks · Quantitative Biology 2013-01-08 Stefan R. Maetschke , Piyush B. Madhamshettiwar , Melissa J. Davis , Mark A. Ragan

Gene Regulatory Networks (GRNs) are intricate biological systems that control gene expression and regulation in response to environmental and developmental cues. Advances in computational biology, coupled with high throughput sequencing…

Machine Learning · Computer Science 2025-04-18 Akshata Hegde , Tom Nguyen , Jianlin Cheng

Gene expression data sets are used to classify and predict patient diagnostic categories. As we know, it is extremely difficult and expensive to obtain gene expression labelled examples. Moreover, conventional supervised approaches cannot…

Machine Learning · Computer Science 2013-07-05 Hala Helmi , Jon M. Garibaldi , Uwe Aickelin

Predicting phenotypes from gene expression data is a crucial task in biomedical research, enabling insights into disease mechanisms, drug responses, and personalized medicine. Traditional machine learning and deep learning rely on…

Machine Learning · Computer Science 2025-09-18 Kevin Dradjat , Massinissa Hamidi , Pierre Bartet , Blaise Hanczar

A semi-supervised learning framework using the feedforward-designed convolutional neural networks (FF-CNNs) is proposed for image classification in this work. One unique property of FF-CNNs is that no backpropagation is used in model…

Computer Vision and Pattern Recognition · Computer Science 2019-02-07 Yueru Chen , Yijing Yang , Min Zhang , C. -C. Jay Kuo

In this paper, we propose another version of help-training approach by employing a Probabilistic Neural Network (PNN) that improves the performance of the main discriminative classifier in the semi-supervised strategy. We introduce the…

Machine Learning · Computer Science 2015-09-07 Hamidreza Farhidzadeh

Gene Regulatory Network (GRN) inference is essential for understanding complex cellular mechanisms, rendered tractable through single-cell transcriptomic data. With the emergence of single-cell Foundation Models (scFMs), enhanced…

Machine Learning · Computer Science 2026-05-12 Jiaxin Qi , Hang Li , Yan Cui , Yuhua Zheng , Jianqiang Huang

We present a novel classification-based method for learning to predict gene regulatory response. Our approach is motivated by the hypothesis that in simple organisms such as Saccharomyces cerevisiae, we can learn a decision rule for…

Quantitative Methods · Quantitative Biology 2007-05-23 Manuel Middendorf , Anshul Kundaje , Chris Wiggins , Yoav Freund , Christina Leslie

We propose a method for semi-supervised training of structured-output neural networks. Inspired by the framework of Generative Adversarial Networks (GAN), we train a discriminator network to capture the notion of a quality of network…

Computer Vision and Pattern Recognition · Computer Science 2017-02-09 Mateusz Koziński , Loïc Simon , Frédéric Jurie

Labeled data used for training activity recognition classifiers are usually limited in terms of size and diversity. Thus, the learned model may not generalize well when used in real-world use cases. Semi-supervised learning augments labeled…

Machine Learning · Computer Science 2018-01-25 Ming Zeng , Tong Yu , Xiao Wang , Le T. Nguyen , Ole J. Mengshoel , Ian Lane

In several domains obtaining class annotations is expensive while at the same time unlabelled data are abundant. While most semi-supervised approaches enforce restrictive assumptions on the data distribution, recent work has managed to…

Machine Learning · Statistics 2017-10-11 Martin Trapp , Tamas Madl , Robert Peharz , Franz Pernkopf , Robert Trappl

Inferring Gene Regulatory Networks (GRNs) from gene expression data is crucial for understanding biological processes. While supervised models are reported to achieve high performance for this task, they rely on costly ground truth (GT)…

Machine Learning · Statistics 2025-06-10 Tianyu Cui , Song-Jun Xu , Artem Moskalev , Shuwei Li , Tommaso Mansi , Mangal Prakash , Rui Liao

Randomized artificial neural networks such as extreme learning machines provide an attractive and efficient method for supervised learning under limited computing ressources and green machine learning. This especially applies when equipping…

Machine Learning · Statistics 2022-01-02 Ansgar Steland , Bart E. Pieters

Effective convolutional neural networks are trained on large sets of labeled data. However, creating large labeled datasets is a very costly and time-consuming task. Semi-supervised learning uses unlabeled data to train a model with higher…

Computer Vision and Pattern Recognition · Computer Science 2016-06-16 Mehdi Sajjadi , Mehran Javanmardi , Tolga Tasdizen

This paper presents a new semi-supervised framework with convolutional neural networks (CNNs) for text categorization. Unlike the previous approaches that rely on word embeddings, our method learns embeddings of small text regions from…

Machine Learning · Statistics 2015-11-03 Rie Johnson , Tong Zhang

In the semi-supervised learning field, Graph Convolution Network (GCN), as a variant model of GNN, has achieved promising results for non-Euclidean data by introducing convolution into GNN. However, GCN and its variant models fail to safely…

Machine Learning · Computer Science 2022-07-06 Zhi Yang , Yadong Yan , Haitao Gan , Jing Zhao , Zhiwei Ye

Semi-supervised learning algorithms reduce the high cost of acquiring labeled training data by using both labeled and unlabeled data during learning. Deep Convolutional Networks (DCNs) have achieved great success in supervised tasks and as…

Machine Learning · Statistics 2016-12-07 Tan Nguyen , Wanjia Liu , Ethan Perez , Richard G. Baraniuk , Ankit B. Patel

Deep neural networks have been widely used in communication signal recognition and achieved remarkable performance, but this superiority typically depends on using massive examples for supervised learning, whereas training a deep neural…

Signal Processing · Electrical Eng. & Systems 2023-11-15 Weidong Wang , Hongshu Liao , Lu Gan

In recent years, several machine learning approaches have been proposed to predict gene expression and epigenetic signals from the DNA sequence alone. These models are often used to deduce, and, to some extent, assess putative new…

Genomics · Quantitative Biology 2023-04-26 Laurent Bréhélin

Semi supervised learning methods have gained importance in today's world because of large expenses and time involved in labeling the unlabeled data by human experts. The proposed hybrid approach uses SVM and Label Propagation to label the…

Machine Learning · Computer Science 2015-12-08 Aruna Govada , Pravin Joshi , Sahil Mittal , Sanjay K Sahay
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