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This paper carries out an analysis of the global properties of solutions of an in-host model of hepatitis C for general values of its parameters. A previously unknown stable steady state on the boundary of the positive orthant is exhibited.…
The synthetic construction of intracellular circuits is frequently hindered by a poor knowledge of appropriate kinetics and precise rate parameters. Here, we use generalized modeling (GM) to study the dynamical behavior of topological…
Recent studies show the existing clinical tests to detect Cardio/cerebrovascular diseases (CVD) are ineffectual as they do not consider different stages of platelet activation or the molecular dynamics involved in platelet interactions.…
We consider a delay differential equation that occurs in the study of chronic myelogenous leukemia. After shortly reminding some previous results concerning the stability of equilibrium solutions, we concentrate on the study of stability of…
Periodic hematological diseases such as cyclical neutropenia or cyclical thrombocytopenia, with their characteristic oscillations of circulating neutrophils or platelets, may pose grave problems for patients. Likewise, periodically…
In this paper we analyze the heteroclinic cycle and the Hopf bifurcation of a generic dynamical system with the symmetry of the group $\mathbf{Q}_8,$ constructed via a Cayley graph. While the Hopf bifurcation is similar to that of a…
Atherosclerosis occurs when plaque clogs the arteries. It is a leading cause of death in the United States and worldwide. In this paper, we study the bifurcation for a highly nonlinear and highly coupled PDE model of plaque formation in the…
Double Hopf bifurcation analysis can be used to reveal some complicated dynamical behavior in a dynamical system, such as the existence or coexistence of periodic orbits, quasi-periodic orbits, or even chaos. In this paper, an algorithm for…
Dynamical systems across the sciences, from electrical circuits to ecological networks, undergo qualitative and often catastrophic changes in behavior, called bifurcations, when their underlying parameters cross a threshold. Existing…
We analyze rate-dependent tipping in a fast/slow system with an equilibrium near the fold of a critical manifiold. We find a Hopf bifurcation as the rate parameter increases in the reduced co-moving system. This implies the growth of a…
Atherosclerosis, hardening of the arteries, originates from small plaque in the arteries; it is a major cause of disability and premature death in the United States and worldwide. In this paper, we study the bifurcation of a highly…
Varying one of the governing parameters of a dynamical system may lead to a critical transition, where the new stable state is undesirable. In some cases, there is only a limited range of the bifurcation parameter that corresponds to that…
Patient subtyping based on temporal observations can lead to significantly nuanced subtyping that acknowledges the dynamic characteristics of diseases. Existing methods for subtyping trajectories treat the evolution of clinical observations…
We perform one and two-parameter numerical bifurcation analysis of a mechanotransduction model approximating the dynamics of mesenchymal stem cell differentiation into neurons, adipocytes, myocytes and osteoblasts. For our analysis, we use…
The cyclicity problem, crucial in analyzing planar vector fields, consists in estimating the number of limit cycles emanating from monodromic singularities. Traditionally, this estimation relies on Lyapunov coefficients. However, in…
Autonomous sustained oscillations are ubiquitous in living and nonliving systems. As open systems, far from thermodynamic equilibrium, they defy entropic laws which mandate convergence to stationarity. We present structural conditions on…
For many physical systems the transition from a stationary solution to sustained small amplitude oscillations corresponds to a Hopf bifurcation. For systems involving impacts, thresholds, switches, or other abrupt events, however, this…
We study a nonlinear PDE problem motivated by the peculiar patterns arising in myxobacteria, namely counter-migrating cell density waves. We rigorously prove the existence of Hopf bifurcations for some specific values of the parameters of…
We explore the bifurcations and dynamics of a scalar differential equation with a single constant delay which models the population of human hematopoietic stem cells in the bone marrow. One parameter continuation reveals that with a delay…
Recent clinical studies have shown that HIV disease pathogenesis can depend strongly on many factors at the time of transmission, including the strength of the initial viral load and the local availability of CD4+ T-cells. In this article,…