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As lung cancer evolves, the presence of enlarged and potentially malignant lymph nodes must be assessed to properly estimate disease progression and select the best treatment strategy. Following the clinical guidelines, estimation of…

Image and Video Processing · Electrical Eng. & Systems 2022-05-03 David Bouget , André Pedersen , Johanna Vanel , Haakon O. Leira , Thomas Langø

Machine learning (ML) is a branch of Artificial Intelligence (AI) where computers analyze data and find patterns in the data. The study focuses on the detection of metastatic cancer using ML. Metastatic cancer is the point where the cancer…

Artificial Intelligence · Computer Science 2023-09-20 Bliss Singhal , Fnu Pooja

Accurate segmentation of metastatic lymph nodes in rectal cancer is crucial for the staging and treatment of rectal cancer. However, existing segmentation approaches face challenges due to the absence of pixel-level annotated datasets…

Computer Vision and Pattern Recognition · Computer Science 2024-04-16 Weidong Guo , Hantao Zhang , Shouhong Wan , Bingbing Zou , Wanqin Wang , Chenyang Qiu , Jun Li , Peiquan Jin

Semantic segmentation of breast cancer metastases in histopathological slides is a challenging task. In fact, significant variation in data characteristics of histopathology images (domain shift) make generalization of deep learning to…

Image and Video Processing · Electrical Eng. & Systems 2021-06-01 Gianluca Gerard , Marco Piastra

Hematoxylin- and eosin (H&E) stained whole-slide images (WSIs) are the foundation of diagnosis of cancer. In recent years, development of deep learning-based methods in computational pathology enabled the prediction of biomarkers directly…

Assessing the pre-operative risk of lymph node metastases in endometrial cancer patients is a complex and challenging task. In principle, machine learning and deep learning models are flexible and expressive enough to capture the dynamics…

Artificial Intelligence · Computer Science 2023-05-18 Alessio Zanga , Alice Bernasconi , Peter J. F. Lucas , Hanny Pijnenborg , Casper Reijnen , Marco Scutari , Fabio Stella

Automatic lymph node segmentation is the cornerstone for advances in computer vision tasks for early detection and staging of cancer. Traditional segmentation methods are constrained by manual delineation and variability in operator…

Image and Video Processing · Electrical Eng. & Systems 2025-06-11 Jingguo Qu , Xinyang Han , Man-Lik Chui , Yao Pu , Simon Takadiyi Gunda , Ziman Chen , Jing Qin , Ann Dorothy King , Winnie Chiu-Wing Chu , Jing Cai , Michael Tin-Cheung Ying

The evaluation of lymph node metastases plays a crucial role in achieving precise cancer staging, influencing subsequent decisions regarding treatment options. Lymph node detection poses challenges due to the presence of unclear boundaries…

Computer Vision and Pattern Recognition · Computer Science 2024-06-07 Sofija Engelson , Jan Ehrhardt , Timo Kepp , Joshua Niemeijer , Heinz Handels

Robust localization of lymph nodes (LNs) in multiparametric MRI (mpMRI) is critical for the assessment of lymphadenopathy. Radiologists routinely measure the size of LN to distinguish benign from malignant nodes, which would require…

Image and Video Processing · Electrical Eng. & Systems 2025-04-08 Tejas Sudharshan Mathai , Sungwon Lee , Thomas C. Shen , Zhiyong Lu , Ronald M. Summers

Prevention and early diagnosis of breast cancer (BC) is an essential prerequisite for the selection of proper treatment. The substantial pressure due to the increase of demand for faster and more precise diagnostic results drives for…

Image and Video Processing · Electrical Eng. & Systems 2021-06-29 Peter Bokor , Lukas Hudec , Ondrej Fabian , Wanda Benesova

Recently, large, high-quality public datasets have led to the development of convolutional neural networks that can detect lymph node metastases of breast cancer at the level of expert pathologists. Many cancers, regardless of the site of…

Image and Video Processing · Electrical Eng. & Systems 2022-07-14 Péter Bándi , Maschenka Balkenhol , Marcory van Dijk , Bram van Ginneken , Jeroen van der Laak , Geert Litjens

Recent studies have shown promising results in using Deep Learning to detect malignancy in whole slide imaging. However, they were limited to just predicting positive or negative finding for a specific neoplasm. We attempted to use Deep…

Computer Vision and Pattern Recognition · Computer Science 2018-11-08 Hanadi El Achi , Tatiana Belousova , Lei Chen , Amer Wahed , Iris Wang , Zhihong Hu , Zeyad Kanaan , Adan Rios , Andy N. D. Nguyen

Predicting outcomes, such as survival or metastasis for individual cancer patients is a crucial component of precision oncology. Machine learning (ML) offers a promising way to exploit rich multi-modal data, including clinical information…

Machine Learning · Computer Science 2021-06-04 Michal Kazmierski , Benjamin Haibe-Kains

Recent breakthroughs in object detection and image classification using Convolutional Neural Networks (CNNs) are revolutionizing the state of the art in medical imaging, and microscopy in particular presents abundant opportunities for…

Image and Video Processing · Electrical Eng. & Systems 2020-07-07 Rui Aguiar , Jon Braatz

Digital pathology and microscopy image analysis are widely employed in the segmentation of digitally scanned IHC slides, primarily to identify cancer and pinpoint regions of interest (ROI) indicative of tumor presence. However, current ROI…

Computer Vision and Pattern Recognition · Computer Science 2024-06-11 Akash Modi , Sumit Kumar Jha , Purnendu Mishra , Rajiv Kumar , Kiran Aatre , Gursewak Singh , Shubham Mathur

Joint analysis of multiple biomarker images and tissue morphology is important for disease diagnosis, treatment planning and drug development. It requires cross-staining comparison among Whole Slide Images (WSIs) of immuno-histochemical and…

Image and Video Processing · Electrical Eng. & Systems 2022-07-05 Abubakr Shafique , Morteza Babaie , Mahjabin Sajadi , Adrian Batten , Soma Skdar , H. R. Tizhoosh

The Quadrant-Slope Index (QSI) method was created in order to detect subtle patterns of organization in tumor images that have metaplastic elements, such as streams of spindle cells [1]. However, metaplastic tumors also have nuclei that may…

Tissues and Organs · Quantitative Biology 2017-04-26 David H. Nguyen

Pathological lymph node delineation is crucial in cancer diagnosis, progression assessment, and treatment planning. The MICCAI 2023 Lymph Node Quantification Challenge published the first public dataset for pathological lymph node…

Computer Vision and Pattern Recognition · Computer Science 2024-06-24 Stefan M. Fischer , Johannes Kiechle , Daniel M. Lang , Jan C. Peeken , Julia A. Schnabel

Histopathological image analysis is an essential process for the discovery of diseases such as cancer. However, it is challenging to train CNN on whole slide images (WSIs) of gigapixel resolution considering the available memory capacity.…

Image and Video Processing · Electrical Eng. & Systems 2019-10-11 Shusuke Takahama , Yusuke Kurose , Yusuke Mukuta , Hiroyuki Abe , Masashi Fukayama , Akihiko Yoshizawa , Masanobu Kitagawa , Tatsuya Harada

Manual counting of mitotic tumor cells in tissue sections constitutes one of the strongest prognostic markers for breast cancer. This procedure, however, is time-consuming and error-prone. We developed a method to automatically detect…