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We present a theoretical study of single-stranded DNA under stretching. Within the proposed framework, the effects of basepairing on the mechanical response of the molecule can be studied in combination with an arbitrary underlying model of…

Soft Condensed Matter · Physics 2009-11-10 Alexei V. Tkachenko

We consider mechanical stability of dimeric and monomeric proteins with the cystine knot motif. A structure based dynamical model is used to demonstrate that all dimeric and some monomeric proteins of this kind should have considerable…

Biomolecules · Quantitative Biology 2013-03-28 Mateusz Sikora , Marek Cieplak

We use computer simulations and scaling arguments to investigate statistical and structural properties of a semiflexible ribbon composed of isosceles triangles. We study two different models, one where the bending energy is calculated from…

Statistical Mechanics · Physics 2009-11-07 Boris Mergell , Mohammad R. Ejtehadi , Ralf Everaers

A double stranded DNA molecule under the stress of a pulling force acting on the strand terminals exhibits a partially denatured structure or can be completely unzipped depending the magnitude of the pulling force. A scaling argument for…

Statistical Mechanics · Physics 2009-09-25 Jeff Z. Y. Chen

DNA supercoiling plays an important role in a variety of cellular processes. The torsional stress related with supercoiling may be also involved in gene regulation through the local structure and dynamics of the double helix. To check this…

Biomolecules · Quantitative Biology 2015-05-19 Alexey K. Mazur

It has become clear in recent years that the simple uniform wormlike chain model needs to be modified in order to account for more complex behavior which has been observed experimentally in some important biopolymers. For example, the large…

Soft Condensed Matter · Physics 2017-11-01 Panayotis Benetatos

Cells regulate gene expression in part by forming DNA-protein condensates in the nucleus. While existing theories describe the equilibrium size and stability of such condensates, their dynamics remain less understood. Here, we use…

Soft Condensed Matter · Physics 2025-12-22 Adam R. Lamson , Mohammadhossein Firouznia , Michael J. Shelley

A comprehensive study has been undertaken on the dimensional swelling of graphene-reinforced elastomers in liquids. Anisotropic swelling was observed for samples reinforced with graphene nanoplatelets (GNPs), induced by the in-plane…

Applied Physics · Physics 2020-03-25 Mufeng Liu , Suhao Li , Ian A. Kinloch , Robert J. Young , Dimitrios G. Papageorgiou

We study the unzipping of a double stranded DNA (dsDNA) by applying an external force on a single strand while leaving the other strand free. We find that the dsDNA can be unzipped to two single strands if the external force exceeds a…

Soft Condensed Matter · Physics 2009-06-02 Rajeev Kapri

In this paper we consider the anharmonic corrections to the anisotropic elastic rod model for DNA. Our model accounts for the difference between the bending energies of positive and negative rolls, which comes from the asymmetric structure…

Soft Condensed Matter · Physics 2009-04-28 B. Eslami-Mossallam , M. R. Ejtehadi

A simple model of DNA based on two interacting polymers has been used to study the unzipping of a double stranded DNA subjected to a periodic force. We propose a dynamical transition, where without changing the physiological condition, it…

Biological Physics · Physics 2015-06-11 Sanjay Kumar , Garima Mishra

The mechanism of threshold elongation (overstretching) of DNA macromolecules under the action of external force is studied within the framework of phenomenological approach. When considering the task it is taken into account that…

Biomolecules · Quantitative Biology 2016-02-22 Sergey N. Volkov

We investigate the properties of natural two-dimensional (2D) magnetoplasma modes in laterally confined electron systems, such as 2D materials, quantum wells, or inversion layers in semiconductors, with an elliptic Fermi surface. The…

Mesoscale and Nanoscale Physics · Physics 2025-11-18 D. A. Rodionov , I. V. Zagorodnev

Polymers are a primary building block in many biomaterials, often interacting with anisotropic backgrounds. While previous studies have considered polymer dynamics within nematic solvents, rarely are the the effects of anisotropic viscosity…

We report a structural polymorphism of the S-DNA when a canonical B-DNA is stretched under different pulling protocols and provide a fundamental molecular understanding of the DNA stretching mechanism. Extensive all atom molecular dynamics…

Biological Physics · Physics 2018-01-17 Ashok Garai , Santosh Mogurampelly , Saientan Bag , Prabal K. Maiti

When pulled along its axis, double-stranded DNA elongates abruptly at a force of about 65 pN. Two physical pictures have been developed to describe this overstretched state. The first proposes that strong forces induce a phase transition to…

Statistical Mechanics · Physics 2015-06-25 Stephen Whitelam , Sander Pronk , Phillip L. Geissler

We study the melting of a double stranded DNA in the presence of stretching forces, via 3D Monte-Carlo simulations, exactly solvable models and heuristic arguments. The resulting force-temperature phase diagram is dramatically different for…

Soft Condensed Matter · Physics 2008-07-22 D. Marenduzzo , A. Maritan , E. Orlandini , F. Seno , A. Trovato

DNA detection is of great significance in the point-of-care diagnostics. The stiffness of DNA, varying with its sequence and mechanochemical environment, could be a potential marker for DNA identification. The steric configurations of DNA…

Biological Physics · Physics 2019-08-06 Haiqian Yang , Liu Yang , Shaobao Liu

The quite recent technological rise in molecular biology allowed single molecule manipulation experiments, where molecule stretching plays a primary role. In order to understand the experimental data, it is felt the urge of some physical…

Biological Physics · Physics 2011-01-28 Francesco A. Massucci , Isaac Pérez Castillo , Conrad Pérez Vicente

The dynamics of flexible polymers in dilute solution is usually described in terms of the pure Rouse or Zimm bead-spring models assuming continuous distribution of the internal relaxation modes. We show that this approach may lead to…

Soft Condensed Matter · Physics 2007-05-23 J. Tothova , B. Brutovsky , V. Lisy
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