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Coupled human-environment systems are increasingly being understood as complex adaptive systems (CAS), in which micro-level interactions between components lead to emergent behavior. Agent-based models (ABMs) hold great promise for…

Applications · Statistics 2026-02-20 Dylan Munson , Arijit Dey , Simon Mak

Given the large size and complexity of most biochemical regulation and signaling networks, there is a non-trivial relationship between the micro-level logic of component interactions and the observed macro-dynamics. Here we address this…

Molecular Networks · Quantitative Biology 2023-04-19 Thomas Parmer , Luis M. Rocha

Causal discovery based on observational data is important for deciphering the causal mechanism behind complex systems. However, the effectiveness of existing causal discovery methods is limited due to inferior prior knowledge, domain…

Machine Learning · Statistics 2024-05-15 Wenrui Li , Wei Zhang , Qinghao Zhang , Xuegong Zhang , Xiaowo Wang

Deciphering the control principles of metabolism and its interaction with other cellular functions is central to biomedicine and biotechnology. Yet, understanding the efficient control of metabolic fluxes remains elusive for large-scale…

Molecular Networks · Quantitative Biology 2015-09-04 Georg Basler , Zoran Nikoloski , Abdelhalim Larhlimi , Albert-László Barabási , Yang-Yu Liu

Artificial Intelligence (AI) systems have shown good success at classifying. However, the lack of explainability is a true and significant challenge, especially in high-stakes domains, such as health and finance, where understanding is…

Machine Learning · Computer Science 2026-01-14 A. M. A. S. D. Alagiyawanna , Asoka Karunananda , Thushari Silva , A. Mahasinghe

Networked systems are systems of interconnected components, in which the dynamics of each component are influenced by the behavior of neighboring components. Examples of networked systems include biological networks, critical…

Systems and Control · Computer Science 2016-06-01 Andrew Clark , Basel Alomair , Linda Bushnell , Radha Poovendran

This paper introduces a real-time algorithm for navigating complex unknown environments cluttered with movable obstacles. Our algorithm achieves fast, adaptable routing by actively attempting to manipulate obstacles during path planning and…

Robotics · Computer Science 2024-04-12 Botao He , Guofei Chen , Wenshan Wang , Ji Zhang , Cornelia Fermuller , Yiannis Aloimonos

In the freeway network control (FNC) problem, the operation of a traffic network is optimized using only flow control. For special cases of the FNC problem, in particular the case when all merging flows are controlled, there exist tight…

Optimization and Control · Mathematics 2018-03-30 Marius Schmitt , John Lygeros

Deep Research systems based on web agents have shown strong potential in solving complex information-seeking tasks, yet their search efficiency remains underexplored. We observe that many state-of-the-art open-source web agents rely on long…

Artificial Intelligence · Computer Science 2026-05-11 Junjie Wang , Zequn Xie , Dan Yang , Jie Feng , Yue Shen , Duolin Sun , Meixiu Long , Yihan Jiao , Zhehao Tan , Jian Wang , Peng Wei , Jinjie Gu

A procedure to characterize chaotic dynamical systems with concepts of complex networks is pursued, in which a dynamical system is mapped onto a network. The nodes represent the regions of space visited by the system, while edges represent…

Statistical Mechanics · Physics 2011-12-20 Ernesto P. Borges , Daniel O. Cajueiro , Roberto F. S. Andrade

This paper proposes a simplified version of classical models for urban transportation networks, and studies the problem of controlling intersections with the goal of optimizing network-wide congestion. Differently from traditional…

Optimization and Control · Mathematics 2018-11-08 Gianluca Bianchin , Fabio Pasqualetti

In a previous work, we introduced the fuzzy Ethical Decision-Making framework (fEDM), a risk-based ethical reasoning architecture grounded in fuzzy logic. The original model combined a fuzzy Ethical Risk Assessment module (fERA) with…

Artificial Intelligence · Computer Science 2026-03-02 Abeer Dyoub , Francesca A. Lisi

In this theoretical article, a sociotechnical approach is proposed to characterize. First, the business ecosystem, focusing on the relationships among Providers, Enterprise, and Customers through SCM, ERP, and CRM platforms to align: (1)…

Computers and Society · Computer Science 2025-02-03 Leoncio Jimenez , Francisco Venegas

Progress in computer use agents (CUAs) has been constrained by the absence of large and high-quality datasets that capture how humans interact with a computer. While LLMs have thrived on abundant textual data, no comparable corpus exists…

We propose a information theoretical framework to capture transition and information costs of network navigation models. Based on the minimum description length principle and the Markov decision process, we demonstrate that efficient global…

Social and Information Networks · Computer Science 2020-01-14 Xiaoran Yan , Olaf Sporns , Andrea Avena-Koenigsberger

The capacity to predict and control bioprocesses is perhaps one of the most important objectives of biotechnology. Computational simulation is an established methodology for the design and optimization of bioprocesses, where the finite…

Computational Engineering, Finance, and Science · Computer Science 2015-08-12 R. C. Martins , N. Fachada

Networked systems display complex patterns of interactions between a large number of components. In physical networks, these interactions often occur along structural connections that link components in a hard-wired connection topology,…

Neurons and Cognition · Quantitative Biology 2018-04-03 Jason Kim , Jonathan M. Soffer , Ari E. Kahn , Jean M. Vettel , Fabio Pasqualetti , Danielle S. Bassett

We consider the problem of making a networked system contracting by designing minimal effort local controllers. Our method combines a hierarchical contraction characterization and a matrix-balancing approach to stabilizing a Metzler matrix…

Optimization and Control · Mathematics 2022-03-22 Ron Ofir , Francesco Bullo , Michael Margaliot

Driving a system from one state to another through targeted interventions is a fundamental challenge in science, yet most predictive models offer limited mechanistic insight and no principled framework for decision-making. Here we present…

Machine Learning · Computer Science 2026-05-29 Zixuan Song , Uwe Mueller , Dimitris V. Manatakis

This study introduces a method based on link analysis to investigate the structure of the R&D support infrastructure associated with science parks in order to determine whether this webometric approach gives plausible results. Three science…

Digital Libraries · Computer Science 2013-01-22 David Minguillo , Mike Thelwall