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Quality control in molecular optical sectioning microscopy is indispensable for transforming acquired digital images from qualitative descriptions to quantitative data. Although numerous tools, metrics, and phantoms have been developed,…

In Multiple-Input Multiple-Output (MIMO) systems, Sphere Decoding (SD) can achieve performance equivalent to full search Maximum Likelihood (ML) decoding, with reduced complexity. Several researchers reported techniques that reduce the…

Information Theory · Computer Science 2015-03-13 Boyu Li , Ender Ayanoglu

Scanning transmission X-ray microscopy (STXM) is a nanoscale imaging technique that can utilize several powerful contrast mechanisms for the quantitative mapping of chemical and physical materials properties. Spatial resolutions down to…

Instrumentation and Detectors · Physics 2026-05-27 Simone Finizio , Benjamin Watts , Benedikt Rösner , Tim A. Butcher , Sebastian Wintz , Markus Weigand , Jörg Raabe

We report the development of a multichannel microscopy for whole-slide multiplane, multispectral, and phase imaging. We use trinocular heads to split the beam path into 6 independent channels and employ a camera array for parallel data…

Instrumentation and Detectors · Physics 2017-08-24 Jun Liao , Zhe Wang , Zibang Zhang , Zichao Bian , Kaikai Guo , Aparna Nambiar , Yutong Jiang , Shaowei Jiang , Jingang Zhong , Michael Choma , Guoan Zheng

While electron microscopy offers crucial atomic-resolution insights into structure-property relationships, radiation damage severely limits its use on beam-sensitive materials like proteins and 2D materials. To overcome this challenge, we…

Computer Vision and Pattern Recognition · Computer Science 2025-07-18 Zifei Wang , Zian Mao , Xiaoya He , Xi Huang , Haoran Zhang , Chun Cheng , Shufen Chu , Tingzheng Hou , Xiaoqin Zeng , Yujun Xie

In multi-photon microscopy (MPM), a recent in-vivo fluorescence microscopy system, the task of image restoration can be decomposed into two interlinked inverse problems: firstly, the characterization of the Point Spread Function (PSF) and…

Image and Video Processing · Electrical Eng. & Systems 2024-11-08 Julien Ajdenbaum , Emilie Chouzenoux , Claire Lefort , Ségolène Martin , Jean-Christophe Pesquet

In this work, we propose a simple transformer-based baseline for multimodal molecular representation learning, integrating three distinct modalities: SMILES strings, 2D graph representations, and 3D conformers of molecules. A key aspect of…

Machine Learning · Computer Science 2024-10-25 Andrei Manolache , Dragos Tantaru , Mathias Niepert

Medical image retrieval is essential for clinical decision-making and translational research, relying on discriminative visual representations. Yet, current methods remain fragmented, relying on separate architectures and training…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Che Liu , Zheng Jiang , Chengyu Fang , Heng Guo , Yan-Jie Zhou , Jiaqi Qu , Le Lu , Minfeng Xu

Multi-contrast MRI methods acquire multiple images with different contrast weightings, which are used for the differentiation of the tissue types or quantitative mapping. However, the scan time needed to acquire multiple contrasts is…

Image and Video Processing · Electrical Eng. & Systems 2025-02-18 Yan Chen , Jyothi Rikhab Chand , Steven R. Kecskemeti , James H. Holmes , Mathews Jacob

Structured illumination microscopy (SIM) reconstructs a super-resolved image from multiple raw images captured with different illumination patterns; hence, acquisition speed is limited, making it unsuitable for dynamic scenes. We propose a…

Optics · Physics 2025-06-17 Ruiming Cao , Fanglin Linda Liu , Li-Hao Yeh , Laura Waller

We present an approach for two-dimensional (2D) imaging through a single single-mode or multimode fiber without the need for scanners. A random scattering medium placed next to the distal end of the fiber is used to encode the collected…

Optics · Physics 2014-11-04 Sylwia M. Maliszewska , Ori Katz , Mathias Fink , Sylvain Gigan

We propose a speed-up method for the in-focus plane detection in digital holographic microscopy that can be applied to a broad class of autofocusing algorithms that involve repetitive propagation of an object wave to various axial locations…

Quantitative Methods · Quantitative Biology 2023-05-19 Julianna Winnik , Damian Suski , Piotr Zdańkowski , Luiza Stanaszek , Vicente Micó , Maciej Trusiak

3D super-resolution fluorescence microscopy typically requires sophisticated setups, sample preparation, or long measurements. A notable exception, SOFI, only requires recording a sequence of frames and no hardware modifications whatsoever…

Optics · Physics 2024-03-01 Pawel Szczypkowski , Monika Pawlowska , Radek Lapkiewicz

Non-destructive testing and medical diagnostic techniques using ultrasound has become indispensable in evaluating the state of materials or imaging the internal human body, respectively. To conduct spatially resolved high-quality…

Applied Physics · Physics 2023-07-17 Wei Wang , Jie Hu , Jingjing Liu , Yang Tan , Jing Yang , Bin Liang , Johan Christensen , Jianchun Cheng

In clinical practice, 2D magnetic resonance (MR) sequences are widely adopted. While individual 2D slices can be stacked to form a 3D volume, the relatively large slice spacing can pose challenges for both image visualization and subsequent…

Image and Video Processing · Electrical Eng. & Systems 2024-06-11 Xin Wang , Zhiyun Song , Yitao Zhu , Sheng Wang , Lichi Zhang , Dinggang Shen , Qian Wang

Single-beam super-resolution microscopy, also known as superlinear microscopy, exploits the nonlinear response of fluorescent probes in confocal microscopy. The technique requires no complex purpose-built system, light field modulation, or…

Image sensors are the backbone of many imaging technologies of great importance to modern sciences, being particularly relevant in biomedicine. An ideal image sensor should be usable through all the electromagnetic spectrum (large…

Medical Physics · Physics 2022-03-16 Juan Aguirre

Three-dimensional segmentation in magnetic resonance images (MRI), which reflects the true shape of the objects, is challenging since high-resolution isotropic MRIs are rare and typical MRIs are anisotropic, with the out-of-plane dimension…

Image and Video Processing · Electrical Eng. & Systems 2023-03-15 Hanxue Gu , Hongyu He , Roy Colglazier , Jordan Axelrod , Robert French , Maciej A Mazurowski

PURPOSE: Interactive cardiac magnetic resonance imaging is used for fast scan planning and MR guided interventions. However, the requirement for real-time acquisition and near real-time visualization constrains the achievable…

Computer Vision and Pattern Recognition · Computer Science 2024-09-01 Olivier Jaubert , Javier Montalt-Tordera , Daniel Knight , Pr. Simon Arridge , Jennifer Steeden , Pr. Vivek Muthurangu

One of the main characteristics of optical imaging systems is the spatial resolution, which is restricted by the diffraction limit to approximately half the wavelength of the incident light. Along with the recently developed classical…

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