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Biomolecular machines transduce free energy from one form to another to fulfill many important roles inside cells, with dissipation required to achieve directed progress. We investigate how to break time-reversal symmetry at a given…

Statistical Mechanics · Physics 2019-07-03 Arshia Zarrin , David A. Sivak , Aidan I. Brown

Microscopic biological systems operate far from equilibrium, are subject to strong fluctuations, and are composed of many coupled components with interactions varying in nature and strength. Researchers are actively investigating the…

Statistical Mechanics · Physics 2023-12-25 Emma Lathouwers , David A. Sivak

Living systems efficiently use chemical fuel to do work, process information, and assemble patterns despite thermal noise. Whether high efficiency arises from general principles or specific fine-tuning is unknown. Here, applying a recent…

Biological Physics · Physics 2022-10-11 Milo M Lin

There does not exist a general positive correlation between important life-supporting properties and the entropy production rate. The simple reason is that nondissipative and time-symmetric kinetic aspects are also relevant for establishing…

Statistical Mechanics · Physics 2018-04-12 Marco Baiesi , Christian Maes

Breakdown of time-reversal symmetry is a defining property of non-equilibrium systems, such as active matter, which is composed of units that consume energy. We employ a formalism that allows us to derive a class of identities associated…

Statistical Mechanics · Physics 2025-09-26 Martin Kjøllesdal Johnsrud , Ramin Golestanian

Both natural and engineered supply networks exhibit universal structural patterns, such as the formation of loops, yet the principles governing optimal structures remain unclear. These patterns can be interpreted as solutions of…

Adaptation and Self-Organizing Systems · Physics 2026-04-21 Aarathi Parameswaran , Andrea Benigni , Dirk Witthaut , Iva Bačić

Biological molecular machines are enzymes that simultaneously catalyze two processes, one donating free energy and second accepting it. Recent studies show that most native protein enzymes have a rich stochastic dynamics that often…

Biological Physics · Physics 2018-12-21 Michal Kurzynski , Przemyslaw Chelminiak

Biomolecular machines consume free energy to break symmetry and make directed progress. Nonequilibrium ATP concentrations are the typical free energy source, with one cycle of a molecular machine consuming a certain number of ATP, providing…

Statistical Mechanics · Physics 2017-10-23 Aidan I Brown , David A Sivak

We investigate signatures of broken time reversal symmetry in stochastic trajectory data, employing the previously introduced three point correlation called mean back relaxation. We specifically investigate data from a simple driven model,…

Soft Condensed Matter · Physics 2026-03-18 Gabriel Knotz , Till M. Muenker , Timo Betz , Matthias Krüger

Fundamental interactions are either fully or nearly symmetric under time reversal. But macroscopic phenomena have a definite arrow of time. Though there is no convergence on the origin of time's preferential direction, many researchers…

Fluid Dynamics · Physics 2019-11-25 Mahendra K. Verma

Biological molecular machines are bifunctional enzymes that catalyze two processes: one donating free energy and the other accepting it. Recent studies show that most protein enzymes have rich stochastic dynamics of transitions between the…

Biological Physics · Physics 2023-02-02 Michal Kurzynski , Przemyslaw Chelminiak

We derive general trade-off relations among the power, efficiency, and constancy for two-terminal thermoelectric systems in the linear response regime. Constancy, which quantifies the steadiness of the heat engine, is measured by its…

Statistical Mechanics · Physics 2026-04-09 Ousi Pan , Zhiqiang Fan , Shunjie Zhang , Liwei Chen , Jincan Chen , Shanhe Su

Biomolecular machines transduce between different forms of energy. These machines make directed progress and increase their speed by consuming free energy, typically in the form of nonequilibrium chemical concentrations. Machine dynamics…

Statistical Mechanics · Physics 2018-10-05 Aidan I Brown , David A Sivak

Active matter constantly dissipates energy to power the self-propulsion of its microscopic constituents. This opens the door to designing innovative cyclic engines without any equilibrium equivalent. We offer a consistent thermodynamic…

Soft Condensed Matter · Physics 2020-07-08 Timothy Ekeh , Michael E. Cates , Étienne Fodor

Microscopic machines utilize free energy to create and maintain out-of-equilibrium organization in virtually all living things. Often this takes the form of converting the free energy stored in nonequilibrium chemical potential differences…

Statistical Mechanics · Physics 2019-08-23 Steven J. Large , David A. Sivak

Stochastic fluctuations of molecular abundances are a ubiquitous feature of cellular processes and lead to significant cell-to-cell variability. Recent theoretical work established lower bounds for stochastic fluctuations in cells for broad…

Molecular Networks · Quantitative Biology 2025-05-06 Brayden Kell , Andreas Hilfinger

Active matter encompasses systems whose individual consituents dissipate energy to exert propelling forces on their environment. This rapidly developing field harbors a dynamical phenomenology with no counterpart in passive systems. The…

Statistical Mechanics · Physics 2023-12-19 Jérémy O'Byrne , Yariv Kafri , Julien Tailleur , Frédéric van Wijland

Minimal models of active and driven particles have recently been used to elucidate many properties non-equilibrium systems. However, the relation between energy consumption and changes in the structure and transport properties of these…

Soft Condensed Matter · Physics 2017-08-03 Clara del Junco , Laura Tociu , Suriyanarayanan Vaikuntanathan

The reciprocity principle governs the symmetry in transmission of electromagnetic and acoustic waves, as well as the diffusion of heat between two points in space, with important consequences for thermal management and energy harvesting.…

Applied Physics · Physics 2022-01-19 Jiaxin Li , Ying Li , Pei-Chao Cao , Xu Zheng , Yu-Gui Peng , Baowen Li , Xue-Feng Zhu , Andrea Alù , Cheng-Wei Qiu

Physical systems that power motion and create structure in a fixed amount of time dissipate energy and produce entropy. Whether living or synthetic, systems performing these dynamic functions must balance dissipation and speed. Here, we…

Statistical Mechanics · Physics 2020-12-18 Schuyler B. Nicholson , Luis Pedro Garcia-Pintos , Adolfo del Campo , Jason R. Green
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