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Computational models and simulations are not just appealing because of their intrinsic characteristics across spatiotemporal scales, scalability, and predictive power, but also because the set of problems in cancer biomedicine that can be…

Tissues and Organs · Quantitative Biology 2023-11-01 Nicolò Cogno , Cristian Axenie , Roman Bauer , Vasileios Vavourakis

When the body gets infected by a pathogen or receives a vaccine dose, the immune system develops pathogen-specific immunity. Induced immunity decays in time and years after recovery/vaccination the host might become susceptible again.…

Populations and Evolution · Quantitative Biology 2015-01-15 Maria Vittoria Barbarossa , Gergely Röst

Artificial immune system can be used to generate schedules in changing environments and it has been proven to be more robust than schedules developed using a genetic algorithm. Good schedules can be produced especially when the number of…

Neural and Evolutionary Computing · Computer Science 2010-07-05 Uwe Aickelin , Edmund Burke , Aniza Din

Many complex systems experience damage accumulation which leads to aging, manifest as an increasing probability of system collapse with time. This naturally raises the question of how to maximize health and longevity in an aging system at…

Populations and Evolution · Quantitative Biology 2020-12-02 Eric D. Sun , Thomas C. T. Michaels , L. Mahadevan

Establishing the long-term, causal impact of psychological interventions on life outcomes is a grand challenge for the social sciences, caught between the limitations of correlational longitudinal studies and short-term randomized…

Computers and Society · Computer Science 2025-12-23 Vivienne L'Ecuyer Ming

Systems biology models are useful models of complex biological systems that may require a large amount of experimental data to fit each model's parameters or to approximate a likelihood function. These models range from a few to thousands…

Quantitative Methods · Quantitative Biology 2024-07-12 Vincent D. Zaballa , Elliot E. Hui

Human-like Agents with diverse and dynamic personalities could serve as an essential design probe in the process of user-centered design, thereby enabling designers to enhance the user experience of interactive applications. In this…

Human-Computer Interaction · Computer Science 2024-06-18 Jiale Li , Jiayang Li , Jiahao Chen , Yifan Li , Shijie Wang , Hugo Zhou , Minjun Ye , Yunsheng Su

As countries interact more and more, technology gains a decisive role in facilitating today's increased need for interconnection. At the same time, systems, becoming more advanced as technology progresses, feed each other and can produce…

Systems and Control · Electrical Eng. & Systems 2021-12-14 Evripidis P. Kechagias , Dimitrios M. Miloulis , Georgios Chatzistelios , Sotiris P. Gayialis , Georgios A. Papadopoulos

Agent-based models (ABMs) and video games, including those taking advantage of virtual reality (VR), have undergone a remarkable parallel evolution, achieving impressive levels of complexity and sophistication. This paper argues that while…

We present our preliminary work on a multi-agent system involving the complex human phenomena of identity and dynamic teams. We outline our ongoing experimentation into understanding how these factors can eliminate some of the naive…

Multiagent Systems · Computer Science 2023-01-05 Kyle Tilbury , Jesse Hoey

This paper describes an agent-based model of epidemics dynamics. This model is willingly simplified, as its goal is not to predict the evolution of the epidemics, but to explain the underlying mechanisms in an interactive way. This model…

Multiagent Systems · Computer Science 2024-04-16 Carole Adam , Helene Arduin

Agent-based modeling plays an essential role in gaining insights into biology, sociology, economics, and other fields. However, many existing agent-based simulation platforms are not suitable for large-scale studies due to the low…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-04-25 Lukas Breitwieser , Ahmad Hesam , Fons Rademakers , Juan Gómez Luna , Onur Mutlu

Several approaches are proposed to deal with the problem of the Automatic Schema Matching (ASM). The challenges and difficulties caused by the complexity and uncertainty characterizing both the process and the outcome of Schema Matching…

Artificial Intelligence · Computer Science 2025-01-09 Hicham Assoudi , Hakim Lounis

Integrative biological simulations have a varied and controversial history in the biological sciences. From computational models of organelles, cells, and simple organisms, to physiological models of tissues, organ systems, and ecosystems,…

Quantitative Methods · Quantitative Biology 2017-12-06 Gopal P. Sarma , Victor Faundez

Agent-based modeling is indispensable for studying complex systems across many domains. However, existing simulation platforms exhibit two major issues: performance and modularity. Low performance prevents simulations with a large number of…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-03-17 Lukas Johannes Breitwieser

We are living longer in times of the biggest technological revolution humanity had ever seen before. Trying to understand how these two facts interact with each other, or more specifically, trying to maximise the benefits that new…

Human-Computer Interaction · Computer Science 2020-09-15 L. Morillo-Mendez

With recent and rapid advancements in artificial intelligence (AI), understanding the foundation of purposeful behaviour in autonomous agents is crucial for developing safe and efficient systems. While artificial neural networks have…

Artificial Intelligence · Computer Science 2025-08-12 Aswin Paul , Moein Khajehnejad , Forough Habibollahi , Brett J. Kagan , Adeel Razi

Social-ecological systems research aims to understand the nature of social-ecological phenomena, to find ways to foster or manage conditions under which desired phenomena occur or to reduce the negative consequences of undesirable…

Multiagent Systems · Computer Science 2024-06-25 Sonja Radosavljevic , Udita Sanga , Maja Schlüter

As large language models (LLMs) continue to make significant strides, their better integration into agent-based simulations offers a transformational potential for understanding complex social systems. However, such integration is not…

Physics and Society · Physics 2024-09-04 Önder Gürcan

Modeling how human moves in the space is useful for policy-making in transportation, public safety, and public health. Human movements can be viewed as a dynamic process that human transits between states (\eg, locations) over time. In the…

Artificial Intelligence · Computer Science 2021-03-24 Hua Wei , Dongkuan Xu , Junjie Liang , Zhenhui Li
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