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It is common practice in statistical data analysis to perform data-driven variable selection and derive statistical inference from the resulting model. Such inference enjoys none of the guarantees that classical statistical theory provides…

Statistics Theory · Mathematics 2013-06-06 Richard Berk , Lawrence Brown , Andreas Buja , Kai Zhang , Linda Zhao

Probability models are only useful at explaining the uncertainty of what we do not know, and should never be used to say what we already know. Probability and statistical models are useless at discerning cause. Classical statistical…

Other Statistics · Statistics 2015-07-30 William M. Briggs

The last decades saw dramatic progress in brain research. These advances were often buttressed by probing single variables to make circumscribed discoveries, typically through null hypothesis significance testing. New ways for generating…

Neurons and Cognition · Quantitative Biology 2019-03-26 Danilo Bzdok , John Ioannidis

Note: Published now as a chapter in "Handbook of the History and Philosophy of Mathematical Practice" (Springer Nature, editor B. Sriraman, https://doi.org/10.1007/978-3-030-19071-2_105-1). The application of mathematical probability theory…

Other Statistics · Statistics 2023-11-21 Christian Hennig

In fields that are mainly nonexperimental, such as economics and finance, it is inescapable to compute test statistics and confidence regions that are not probabilistically independent from previously examined data. The Bayesian and…

Statistics Theory · Mathematics 2015-04-20 Benjamin Holcblat , Steffen Grønneberg

The search for a scientific theory of consciousness should result in theories that are falsifiable. However, here we show that falsification is especially problematic for theories of consciousness. We formally describe the standard…

Neurons and Cognition · Quantitative Biology 2021-04-29 Johannes Kleiner , Erik Hoel

Statistical inference in high dimensional settings has recently attracted enormous attention within the literature. However, most published work focuses on the parametric linear regression problem. This paper considers an important…

Methodology · Statistics 2019-11-14 Qi Gao , Randy C. S. Lai , Thomas C. M. Lee , Yao Li

Observational astrophysics consists of making inferences about the Universe by comparing data and models. The credible intervals placed on model parameters are often as important as the maximum a posteriori probability values, as the…

Instrumentation and Methods for Astrophysics · Physics 2021-12-15 Will J. Percival , Oliver Friedrich , Elena Sellentin , Alan Heavens

Empirical science needs to be based on facts and claims that can be reproduced. This calls for replicating the studies that proclaim the claims, but practice in most fields still fails to implement this idea. When such studies emerged in…

Other Statistics · Statistics 2025-08-27 Werner A. Stahel

Investigators often use the data to generate interesting hypotheses and then perform inference for the generated hypotheses. P-values and confidence intervals must account for this explorative data analysis. A fruitful method for doing so…

Methodology · Statistics 2018-02-06 Keli Liu , Jelena Markovic , Robert Tibshirani

Textbooks on statistics emphasize care and precision, via concepts such as reliability and validity in measurement, random sampling and treatment assignment in data collection, and causal identification and bias in estimation. But how do…

Methodology · Statistics 2013-07-24 Andrew Gelman , Keith O'Rourke

Reproducibility, the ability to recompute results, and replicability, the chances other experimenters will achieve a consistent result, are two foundational characteristics of successful scientific research. Consistent findings from…

Applications · Statistics 2015-06-23 Jeffrey T. Leek , Roger D. Peng

Many scholars have called for raising statistical hurdles to guard against false discoveries in academic publications. I show these calls may be difficult to justify empirically. Published data exhibit bias: results that fail to meet…

General Finance · Quantitative Finance 2024-04-09 Andrew Y. Chen

Several scientific fields including psychology are undergoing a replication crisis. There are many reasons for this problem, one of which is a misuse of p-values. There are several alternatives to p-values, and in this paper we describe a…

Methodology · Statistics 2020-10-05 Brian D. Segal

This study has the purpose of addressing four questions that lie at the base of the probability theory and statistics, and includes two main steps. As first, we conduct the textual analysis of the most significant works written by eminent…

History and Overview · Mathematics 2019-01-15 Paolo Rocchi

Especially when facing reliability data with limited information (e.g., a small number of failures), there are strong motivations for using Bayesian inference methods. These include the option to use information from physics-of-failure or…

Methodology · Statistics 2022-10-27 Qinglong Tian , Colin Lewis-Beck , Jarad Niemi , William Meeker

Sparsity in a regression context makes the model itself an object of interest, pointing to a confidence set of models as the appropriate presentation of evidence. A difficulty in areas such as genomics, where the number of candidate…

Statistics Theory · Mathematics 2026-02-24 Heather Battey , Daniel Garcia Rasines , Yanbo Tang

Every scientific endeavour consists of (at least) two components: A hypothesis on the one hand and data on the other. There is always a more or less abstract level - some theory, a set of concepts, certain relations of ideas - and a…

Applications · Statistics 2018-01-08 Uwe Saint-Mont

We formalize the idea of probability distributions that lead to reliable predictions about some, but not all aspects of a domain. The resulting notion of `safety' provides a fresh perspective on foundational issues in statistics, providing…

Methodology · Statistics 2016-04-08 Peter Grünwald

Reliable inference requires that artificial intelligence (AI) models provide trustworthy uncertainty estimates, not merely accurate predictions. Recent advances in Bayesian learning have made significant progress toward this goal, and…

Machine Learning · Computer Science 2026-05-12 Jiayi Huang
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