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We advocate here the use of computational logic for systems biology, as a \emph{unified and safe} framework well suited for both modeling the dynamic behaviour of biological systems, expressing properties of them, and verifying these…
Policy-mandated, rigorously administered scientific testing is needed to provide transparency into the efficacy of artificial intelligence-based (AI-based) cyber defense tools for consumers and to prioritize future research and development.…
The increase of existing computational capabilities has made simulation emerge as a third discipline of Science, lying midway between experimental and purely theoretical branches [1, 2]. Simulation enables the evaluation of quantities which…
The aim of this paper is to propose an alternative behavioural definition of computation (and of a computer) based simply on whether a system is capable of reacting to the environment-the input-as reflected in a measure of programmability.…
The goal of the Human Brain Project is to develop during the next decade an infrastructure necessary for running a simulation of the entire human brain constrained by current experimental data. One of the key issues is therefore to…
Can information theory provide insights into whether exoplanets are habitable? Here we apply information theory to a range of simulated exoplanet transmission spectra as a diagnostic tool to search for potential signatures of life on…
Software production research is quickly evolving on two parallel approaches: conventional and bio-inspired. The bio-inspired approaches are generally developed and presented as enhancements of the conventional ones. However the conventional…
This article is geared towards theorists interested in estimating parameters of their theoretical models, and computing their own limits using available experimental data and elementary Mathematica code. The examples given can be useful…
Contemporary debates on "open science" mostly focus on the pub- lic accessibility of the products of scientific and academic work. In contrast, this paper presents arguments for "opening" the ongoing work of science. That is, this paper is…
Can the theory that reality is a simulation be tested? We investigate this question based on the assumption that if the system performing the simulation is finite (i.e. has limited resources), then to achieve low computational complexity,…
Recent research has extended methods from the fields of thermodynamics and statistical mechanics into other disciplines. Most notably, one recent work creates a unified theoretical framework to understand evolutionary biology, machine…
Provided that there is no theoretical frame for complex engineered systems (CES) as yet, this paper claims that bio-inspired engineering can help provide such a frame. Within CES bio-inspired systems play a key role. The disclosure from…
What is neuroinformatics? We can define it as a direction of science and information technology, dealing with development and study of the methods for solution of problems by means of neural networks. A field of science cannot be determined…
The goal of a well-controlled study is to remove unwanted variation when estimating the causal effect of the intervention of interest. Experiments conducted in the basic sciences frequently achieve this goal using experimental controls,…
Quantum biology is an emerging field of research that concerns itself with the experimental and theoretical exploration of non-trivial quantum phenomena in biological systems. In this tutorial overview we aim to bring out fundamental…
Emerging research frontiers and computational advances have gradually transformed cognitive science into a multidisciplinary and data-driven field. As a result, there is a proliferation of cognitive theories investigated and interpreted…
Software is a great enabler for a number of projects that otherwise would be impossible to perform. Such projects include Space Exploration, Weather Modeling, Genome Projects, and many others. It is critical that software aiding these…
Biological networks are a very convenient modelling and visualisation tool to discover knowledge from modern high-throughput genomics and postgenomics data sets. Indeed, biological entities are not isolated, but are components of complex…
New technologies have enabled the investigation of biology and human health at an unprecedented scale and in multiple dimensions. These dimensions include a myriad of properties describing genome, epigenome, transcriptome, microbiome,…
Although a standard in natural science, reproducibility has been only episodically applied in experimental computer science. Scientific papers often present a large number of tables, plots and pictures that summarize the obtained results,…