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Living systems at the sub-cellular, cellular, and multi-cellular level are often crowded systems that contain active particles. The active motion of these particles can also propel passive particles, which typically results in enhanced…

Soft Condensed Matter · Physics 2021-05-12 Leila Abbaspour , Stefan Klumpp

We calculate the diffusion coefficient of an active tracer in a schematic crowded environment, represented as a lattice gas of passive particles with hardcore interactions. Starting from the master equation of the problem, we put forward a…

Statistical Mechanics · Physics 2022-02-02 Pierre Rizkallah , Alessandro Sarracino , Olivier Bénichou , Pierre Illien

We study analytically the dynamics and the micro-structural changes of a host medium caused by a driven tracer particle moving in a confined, quiescent molecular crowding environment. Imitating typical settings of active micro-rheology…

Statistical Mechanics · Physics 2016-03-17 O. Bénichou , P. Illien , G. Oshanin , A. Sarracino , R. Voituriez

Tracer diffusion in crowded environments is central to many biological and soft matter systems, but quantitative frameworks for linking tracer motion to environmental structure remain limited. Here, we study the transport of rigid tracers…

Soft Condensed Matter · Physics 2026-05-07 Jinseok Lee , Tong Lin , Mengyang Gu , Yimin Luo

We study the diffusion of a tracer particle, which moves in continuum space between a lattice of excluded volume, immobile non-inert obstacles. In particular, we analyse how the strength of the tracer-obstacle interactions and the volume…

Soft Condensed Matter · Physics 2014-12-24 Surya K. Ghosh , Andrey G. Cherstvy , Ralf Metzler

Macromolecular diffusion in strongly confined geometries and crowded environments is still to a large extent an open subject in soft matter physics and biology. In this paper, we employ large-scale Langevin dynamics simulations to…

Soft Condensed Matter · Physics 2020-10-07 T. P. O. Nogueira , H. O. Frota , Francesco Piazza , José Rafael Bordin

Crowded environments modify the diffusion of macromolecules, generally slowing their movement and inducing transient anomalous subdiffusion. The presence of obstacles also modifies the kinetics and equilibrium behavior of tracers. While…

A topic of intense current investigation pursues the question how the highly crowded environment of biological cells affects the dynamic properties of passively diffusing particles. Motivated by recent experiments we report results of…

Statistical Mechanics · Physics 2016-09-28 Surya K. Ghosh , Andrey G. Cherstvy , Denis S. Grebenkov , Ralf Metzler

Tracking of individual particle and studying their motion serves as a direct means to understand the dynamics in crowded and complex environments. In this study, the dynamics of tracer particles in the matrix of dense soft-colloidal…

Soft Condensed Matter · Physics 2023-06-28 Jimpaul Samukcham , Lenin S. Shagolsem

Diffusion of a two component fluid is studied in the framework of differential equations, but where these equations are systematically derived from a well-defined microscopic model. The model has a finite carrying capacity imposed upon it…

Statistical Mechanics · Physics 2015-06-04 D. Fanelli , A. J. McKane , G. Pompili , B. Tiribilli , M. Vassalli , T. Biancalani

Recent Molecular Dynamics simulations of glass-forming liquids revealed superdiffusive fluctuations associated with the position of a tracer particle (TP) driven by an external force. Such anomalous response, whose mechanism remains…

The paper addresses the single-file diffusion in the presence of an absorbing boundary. The emphasis is on an interplay between the hard-core interparticle interaction and the absorption process. The resulting dynamics exhibits several…

Statistical Mechanics · Physics 2014-02-26 Artem Ryabov , Petr Chvosta

We summarise different results on the diffusion of a tracer particle in lattice gases of hard-core particles with stochastic dynamics, which are confined to narrow channels -- single-files, comb-like structures and quasi-one-dimensional…

Statistical Mechanics · Physics 2018-11-14 O. Benichou , P. Illien , G. Oshanin , A. Sarracino , R. Voituriez

We present a multiscale approach to model diffusion in a crowded environment and its effect on the reaction rates. Diffusion in biological systems is often modeled by a discrete space jump process in order to capture the inherent noise of…

Subcellular Processes · Quantitative Biology 2016-03-18 Lina Meinecke

We investigate the obstructed motion of tracer (test) particles in crowded environments by carrying simulations of two-dimensional Gaussian random walk in model fibrinogen monolayers of different orientational ordering. The fibrinogen…

Chemical Physics · Physics 2014-03-14 Michał Cieśla , Ewa Gudowska-Nowak , Francesc Sagués , Igor M. Sokolov

We study the diffusion of a tracer particle driven out-of-equilibrium by an external force and traveling in a dense environment of arbitrary density. The system evolves on a discrete lattice and its stochastic dynamics is described by a…

Statistical Mechanics · Physics 2018-05-23 Pierre Illien , Olivier Bénichou , Gleb Oshanin , Alessandro Sarracino , Raphaël Voituriez

The dynamics of a tracer particle in a glassy matrix of obstacles displays slow complex transport as the free volume approaches a critical value and the void space falls apart. We investigate the emerging subdiffusive motion of the test…

Statistical Mechanics · Physics 2011-01-20 Thomas Franosch , Markus Spanner , Teresa Bauer , Gerd E. Schröder-Turk , Felix Höfling

We study by extensive numerical simulations the dynamics of a hard-core tracer particle (TP) in presence of two competing types of disorder - frozen convection flows on a square random Manhattan lattice and a crowded dynamical environment…

Disordered Systems and Neural Networks · Physics 2020-06-24 Carlos Mejía-Monasterio , Sergei Nechaev , Gleb Oshanin , Oleg Vasilyev

Based on a coarse-grained model, we carry out molecular dynamics simulations to analyze the diffusion of a small tracer particle inside a cylindrical channel whose inner wall is covered with randomly grafted short polymeric chains. We…

Soft Condensed Matter · Physics 2013-06-20 Rajarshi Chakrabarti , Stefan Kesselheim , Peter Kosovan , Christian Holm

Macromolecular crowding plays a principal role in a wide range of biological processes including gene expression, chromosomal compaction, and viral infection. However, the impact that crowding has on the dynamics of nucleic acids remains a…

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