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Molecular Dynamics (MD) codes predict the fundamental properties of matter by following the trajectories of a collection of interacting model particles. To exploit diverse modern manycore hardware, efficient codes must use all available…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-08-04 William R. Saunders , James Grant , Eike H. Müller

With the rapid advancement of computational techniques, Molecular Dynamics (MD) simulations have emerged as powerful tools in biomedical research, enabling in-depth investigations of biological systems at the atomic level. Among the diverse…

Biomolecules · Quantitative Biology 2024-09-05 Reza Bozorgpour

Neural machine translation - using neural networks to translate human language - is an area of active research exploring new neuron types and network topologies with the goal of dramatically improving machine translation performance.…

Particle-In-Cell (PIC) codes are broadly applied to the kinetic simulation of plasmas, from laser-matter interaction to astrophysics. Their heavy simulation cost can be mitigated by using the Single Instruction Multiple Data (SIMD)…

The implicit 2D3V particle-in-cell (PIC) code developed to study the interaction of ultrashort pulse lasers with matter [G. M. Petrov and J. Davis, Computer Phys. Comm. 179, 868 (2008); Phys. Plasmas 18, 073102 (2011)] has been parallelized…

Plasma Physics · Physics 2016-08-24 George M. Petrov , Jack Davis

Parallel code design is a challenging task especially when addressing petascale systems for massive parallel processing (MPP), i.e. parallel computations on several hundreds of thousands of cores. An in-house computational fluid dynamics…

Performance · Computer Science 2018-07-03 Jérôme Frisch , Ralf-Peter Mundani

Visualisations drive all aspects of the Machine Learning (ML) Development Cycle but remain a vastly untapped resource by the research community. ML testing is a highly interactive and cognitive process which demands a human-in-the-loop…

Software Engineering · Computer Science 2023-05-23 Arumoy Shome , Luis Cruz , Arie van Deursen

Comprehending the performance bottlenecks at the core of the intricate hardware-software interactions exhibited by highly parallel programs on HPC clusters is crucial. This paper sheds light on the issue of automatically asynchronous MPI…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-09-06 Ayesha Afzal , Georg Hager , Stefano Markidis , Gerhard Wellein

Path-integral molecular dynamics (PIMD) simulations are crucial for accurately capturing nuclear quantum effects in materials. However, their computational intensity and reliance on multiple software packages often limit their applicability…

Microscopic stress fields are widely used in molecular simulations to understand mechanical behavior. Recently, decomposition methods of multibody forces to central force pairs between the interacting particles have been proposed. Here, we…

Soft Condensed Matter · Physics 2016-11-23 Koh M. Nakagawa , Hiroshi Noguchi

Scientific software is often driven by multiple parameters that affect both accuracy and performance. Since finding the optimal configuration of these parameters is a highly complex task, it extremely common that the software is used…

Computational Engineering, Finance, and Science · Computer Science 2016-08-17 Diego Fabregat-Traver , Ahmed E. Ismail , Paolo Bientinesi

Simulating physical systems is a core component of scientific computing, encompassing a wide range of physical domains and applications. Recently, there has been a surge in data-driven methods to complement traditional numerical simulations…

Machine Learning · Computer Science 2021-08-19 Karl Otness , Arvi Gjoka , Joan Bruna , Daniele Panozzo , Benjamin Peherstorfer , Teseo Schneider , Denis Zorin

The current capacity of computers makes it possible to perform simulations of small systems with portable, explicit-solvent potentials achieving high degree of accuracy. However, simplified models must be employed to exploit the behaviour…

Biomolecules · Quantitative Biology 2015-06-18 R. Capelli , C. Paissoni , P. Sormanni , G. Tiana

With multi-core processors a ubiquitous building block of modern supercomputers, it is now past time to enable applications to embrace these developments in processor design. To achieve exascale performance, applications will need ways of…

Distributed, Parallel, and Cluster Computing · Computer Science 2012-08-13 Michele Weiland , Lawrence Mitchell , Gerard Gorman , Stephan Kramer , Mark Parsons , James Southern

Many computer systems for calculating the proper organization of memory are among the most critical issues. Using a tier cache memory (along with branching prediction) is an effective means of increasing modern multi-core processors'…

Networking and Internet Architecture · Computer Science 2021-05-21 Mohamed A. Hamada , Abdelrahman Abdallah

Tensor product state (TPS) based methods are powerful tools to efficiently simulate quantum many-body systems in and out of equilibrium. In particular, the one-dimensional matrix-product (MPS) formalism is by now an established tool in…

Strongly Correlated Electrons · Physics 2018-12-03 Johannes Hauschild , Frank Pollmann

High resolution simulations of polar ice-sheets play a crucial role in the ongoing effort to develop more accurate and reliable Earth-system models for probabilistic sea-level projections. These simulations often require a massive amount of…

Computational Engineering, Finance, and Science · Computer Science 2022-04-12 Jerry Watkins , Max Carlson , Kyle Shan , Irina Tezaur , Mauro Perego , Luca Bertagna , Carolyn Kao , Matthew J. Hoffman , Stephen F. Price

General matrix-matrix multiplication (GEMM) is a cornerstone of AI computations, making tensor processing engines (TPEs) increasingly critical in GPUs and domain-specific architectures. Existing architectures primarily optimize dataflow or…

Hardware Architecture · Computer Science 2025-03-11 Qizhe Wu , Huawen Liang , Yuchen Gui , Zhichen Zeng , Zerong He , Linfeng Tao , Xiaotian Wang , Letian Zhao , Zhaoxi Zeng , Wei Yuan , Wei Wu , Xi Jin

PLUMED is an open-source software package that is widely used for analyzing and enhancing molecular dynamics simulations that works in conjunction with most available molecular dynamics softwares. While the computational cost of PLUMED…

Computational Physics · Physics 2025-11-05 Daniele Rapetti , Massimiliano Bonomi , Carlo Camilloni , Giovanni Bussi , Gareth A. Tribello

Machine learning potentials (MLPs) have advanced rapidly and show great promise to transform molecular dynamics (MD) simulations. However, most existing software tools are tied to specific MLP architectures, lack integration with standard…

Computational Physics · Physics 2025-06-05 Paul Fuchs , Weilong Chen , Stephan Thaler , Julija Zavadlav
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