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A probabilistic program defines a probability measure over its semantic structures. One common goal of probabilistic programming languages (PPLs) is to compute posterior probabilities for arbitrary models and queries, given observed…

Artificial Intelligence · Computer Science 2016-07-01 Yi Wu , Lei Li , Stuart Russell , Rastislav Bodik

Recent advances in geometric deep learning and generative modeling have enabled the design of novel proteins with a wide range of desired properties. However, current state-of-the-art approaches are typically restricted to generating…

Biomolecules · Quantitative Biology 2025-08-26 Vsevolod Viliuga , Leif Seute , Nicolas Wolf , Simon Wagner , Arne Elofsson , Jan Stühmer , Frauke Gräter

Understanding the intertwined contributions of amino acid sequence and spatial structure is essential to explain protein behaviour. Here, we introduce INFUSSE (Integrated Network Framework Unifying Structure and Sequence Embeddings), a deep…

Quantitative Methods · Quantitative Biology 2025-11-07 Kevin Michalewicz , Mauricio Barahona , Barbara Bravi

PepSIRF is a command-line, module-based open-source software package that facilitates the analysis of data from highly-multiplexed serology assays (e.g., PepSeq or PhIP-Seq). It has nine separate modules in its current release (v1.5.0):…

Quantitative Methods · Quantitative Biology 2022-07-26 Annabelle M. Brown , Evan Bolyen , Isaiah Raspet , John A. Altin , Jason T. Ladner

The knowledge of potentially druggable binding sites on proteins is an important preliminary step towards the discovery of novel drugs. The computational prediction of such areas can be boosted by following the recent major advances in the…

Biomolecules · Quantitative Biology 2021-02-17 Stelios K. Mylonas , Apostolos Axenopoulos , Petros Daras

Semantic Text Embedding is a fundamental NLP task that encodes textual content into vector representations, where proximity in the embedding space reflects semantic similarity. While existing embedding models excel at capturing general…

Computation and Language · Computer Science 2025-06-02 Yiqun Sun , Qiang Huang , Anthony K. H. Tung , Jun Yu

Portability, performance, and productivity are three critical dimensions for evaluating a programming model or compiler infrastructure. Several modern programming models for computational science focus on performance and portability. On the…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-10-01 Brian Kelley , Sivasankaran Rajamanickam

Smishing (SMS phishing) has become a serious cybersecurity threat, especially for elderly and cyber-unaware individuals, causing financial loss and undermining user trust. Although prior work has focused on detecting smishing at the level…

Cryptography and Security · Computer Science 2026-04-14 Carl Lochstampfor , Ayan Roy

Background: The development, optimization and validation of protein modeling methods require efficient tools for structural comparison. Frequently, a large number of models need to be compared with the target native structure. The main…

Biomolecules · Quantitative Biology 2013-03-04 Jamróz Michał , Koliński Andrzej

Effective representation of molecules is a crucial factor affecting the performance of artificial intelligence models. This study introduces a flexible, fragment-based, multiscale molecular representation framework called t-SMILES…

Machine Learning · Computer Science 2024-05-22 Juan-Ni Wu , Tong Wang , Yue Chen , Li-Juan Tang , Hai-Long Wu , Ru-Qin Yu

River is a machine learning library for dynamic data streams and continual learning. It provides multiple state-of-the-art learning methods, data generators/transformers, performance metrics and evaluators for different stream learning…

We investigate a novel non-parametric regression-based clustering algorithm for longitudinal data analysis. Combining natural cubic splines with Gaussian mixture models (GMM), the algorithm can produce smooth cluster means that describe the…

Methodology · Statistics 2022-09-20 Peter Mlakar , Tapio Nummi , Polona Oblak , Jana Faganeli Pucer

Mass spectrometry provides a high-throughput way to identify proteins in biological samples. In a typical experiment, proteins in a sample are first broken into their constituent peptides. The resulting mixture of peptides is then subjected…

Applications · Statistics 2010-11-10 Qunhua Li , Michael J. MacCoss , Matthew Stephens

Computational protein-protein interaction (PPI) prediction techniques can contribute greatly in reducing time, cost and false-positive interactions compared to experimental approaches. Sequence is one of the key and primary information of…

Machine Learning · Computer Science 2022-03-29 Soumyadeep Debnath , Ayatullah Faruk Mollah

Machine learning potentials are an important tool for molecular simulation, but their development is held back by a shortage of high quality datasets to train them on. We describe the SPICE dataset, a new quantum chemistry dataset for…

We present a multiway fusion algorithm capable of directly processing uncertain pairwise affinities. In contrast to existing works that require initial pairwise associations, our MIXER algorithm improves accuracy by leveraging the…

Computer Vision and Pattern Recognition · Computer Science 2023-05-04 Parker C. Lusk , Kaveh Fathian , Jonathan P. How

The application of psychophysiological in human-computer interaction is a growing field with significant potential for future smart personalised systems. Working in this emerging field requires comprehension of an array of physiological…

Human-Computer Interaction · Computer Science 2016-09-27 Jari Torniainen , Andreas Henelius

To adapt text summarization to the multilingual world, previous work proposes multi-lingual summarization (MLS) and cross-lingual summarization (CLS). However, these two tasks have been studied separately due to the different definitions,…

Computation and Language · Computer Science 2023-05-17 Jiaan Wang , Fandong Meng , Duo Zheng , Yunlong Liang , Zhixu Li , Jianfeng Qu , Jie Zhou

Query by Singing/Humming (QBSH) is a Music Information Retrieval (MIR) system with small audio excerpt as query. The rising availability of digital music stipulates effective music retrieval methods. Further, MIR systems support content…

Multimedia · Computer Science 2013-01-10 Trisiladevi C. Nagavi , Nagappa U. Bhajantri

Recent advancements in large language models (LLMs) have enabled in-context learning (ICL)-based methods that significantly outperform fine-tuning approaches for text-to-SQL tasks. However, their performance is still considerably lower than…

Computation and Language · Computer Science 2024-05-14 Dongjun Lee , Choongwon Park , Jaehyuk Kim , Heesoo Park