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Chemotaxis and haptotaxis have been a main theme in the macroscopic study of bacterial and cellular motility. In this work we investigate the influence these processes have on the shape and motility of fast migrating cells. We note that…

Cell Behavior · Quantitative Biology 2016-12-08 Aaron Brunk , Niklas Kolbe , Nikolaos Sfakianakis

Hybrid models of chemotaxis combine agent-based models of cells with partial differential equation models of extracellular chemical signals. In this paper, travelling wave properties of hybrid models of bacterial chemotaxis are…

Biological Physics · Physics 2013-02-13 Benjamin Franz , Chuan Xue , Kevin J. Painter , Radek Erban

Single-cell trajectory analysis aims to reconstruct the biological developmental processes of cells as they evolve over time, leveraging temporal correlations in gene expression. During cellular development, gene expression patterns…

Applications · Statistics 2026-03-30 Junhao Zhu , Kevin Zhang , Zhaolei Zhang , Dehan Kong

We compare chemotaxis, the migration of cells and higher animals in reaction to a chemical stimulus, and similar phenomena originating within gases from temperature differences. Then we explain two easy mathematical models for handling…

Computational Physics · Physics 2007-05-23 Sara L. Vesely

Segregation of different cell types is a crucial process for the pattern formation in tissues, in particular during embryogenesis. Since the involved cell interactions are complex and difficult to measure individually in experiments,…

Cell Behavior · Quantitative Biology 2022-09-21 Florian Franke , Sebatian Aland , Hans-Joachim Böhme , Anja Voss-Böhme , Steffen Lange

Cell migration is closely linked to cell shape, yet cell size is often assumed to remain constant. This assumption is challenged by recent experiments showing that cells undergo volume loss during spreading and swelling upon activation,…

Biological Physics · Physics 2025-05-28 Jonathan E. Ron , Ram M. Adar

Cell proliferation is typically incorporated into stochastic mathematical models of cell migration by assuming that cell divisions occur after an exponentially distributed waiting time. Experimental observations, however, show that this…

Cell Behavior · Quantitative Biology 2018-06-11 Enrico Gavagnin , Matthew J. Ford , Richard L. Mort , Tim Rogers , Christian A. Yates

We provide a review of recent advancements in nonlocal continuous models for migration, mainly from the perspective of its involvement in embryonal development and cancer invasion. Particular emphasis is placed on spatial nonlocality…

Analysis of PDEs · Mathematics 2019-11-14 Li Chen , Kevin Painter , Christina Surulescu , Anna Zhigun

In this paper, we derive a new chemotaxis model with degenerate diffusion and density-dependent chemotactic sensitivity, and we provide a more realistic description of cell migration process for its early and late stages. Different from the…

Analysis of PDEs · Mathematics 2023-07-19 Tianyuan Xu , Shanming Ji , Chunhua Jin , Ming Mei , Jingxue Yin

Cells frequently employ extracellular vesicles, or exosomes, to signal across long distances and coordinate collective actions. Exosomes diffuse slowly, can be actively degraded, and contain stochastic amounts of molecular cargo. These…

Biological Physics · Physics 2025-10-15 Louis González , Andrew Mugler

In studies of the interstellar medium in galaxies, radiative transfer models of molecular emission are useful for relating molecular line observations back to the physical conditions of the gas they trace. However, doing this requires…

Astrophysics of Galaxies · Physics 2019-10-02 Damien de Mijolla , Serena Viti , Jonathan Holdship , Ioanna Manolopoulou , Jeremy Yates

Mathematical models have been widely used to describe the collective movement of bacteria by chemotaxis. In particular, bacterial concentration waves traveling in a narrow channel have been experimentally observed and can be precisely…

Analysis of PDEs · Mathematics 2016-04-15 Casimir Emako , Charlène Gayrard , Axel Buguin , Luís Neves de Almeida , Nicolas Vauchelet

In this work we approach cell migration under a large-scale assumption, so that the system reduces to a particle in motion. Unlike classical particle models, the cell displacement results from its internal activity: the cell velocity is a…

Cell Behavior · Quantitative Biology 2018-08-02 Christèle Etchegaray , Nicolas Meunier

We present simulations of evacuation processes using a recently introduced cellular automaton model for pedestrian dynamics. This model applies a bionics approach to describe the interaction between the pedestrians using ideas from…

Statistical Mechanics · Physics 2015-06-24 Ansgar Kirchner , Andreas Schadschneider

Cell migration is a fundamental process involved in physiological phenomena such as the immune response and morphogenesis, but also in pathological processes, such as the development of tumor metastasis. These functions are effectively…

Cell Behavior · Quantitative Biology 2018-12-26 Christèle Etchegaray , Nicolas Meunier

Collective cell migration in response to a chemical cue occurs in many biological processes such as morphogenesis and cancer metastasis. Clusters of migratory cells in these systems are capable of responding to gradients of less than 1%…

Biological Physics · Physics 2016-08-24 Julien Varennes , Bumsoo Han , Andrew Mugler

Targeting signaling pathways that drive cancer cell migration or proliferation is a common therapeutic approach. A popular experimental technique, the scratch assay, measures the migration and proliferation-driven cell closure of a defect…

This article is devoted to the mathematical modeling of migration of neuroblasts, precursor cells of neurons, along the pathway they usually follow before maturing. This pathway is determined mainly by chemotaxis and the heterogeneous…

The study of cells' dynamical properties is essential to a better understanding of several physiological processes. These properties are directly associated with cells' mechanical parameters experimentally achieved through physical stress.…

Soft Condensed Matter · Physics 2022-01-26 G. Ourique , E. F. Teixeira , L. G. Brunnet