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In shotgun sequencing, the input string (typically, a long DNA sequence composed of nucleotide bases) is sequenced as multiple overlapping fragments of much shorter lengths (called \textit{reads}). Modelling the shotgun sequencing pipeline…

Information Theory · Computer Science 2024-05-14 Hrishi Narayanan , Prasad Krishnan , Nita Parekh

In this paper we propose new techniques to sample arbitrary third-order tensors, with an objective of speeding up tensor algorithms that have recently gained popularity in machine learning. Our main contribution is a new way to select, in a…

Machine Learning · Statistics 2015-02-23 Srinadh Bhojanapalli , Sujay Sanghavi

Genome sequencing has become a central focus in computational biology. A genome study typically begins with sequencing, which produces millions to billions of short DNA fragments known as reads. Read mapping aligns these reads to a…

In this paper, we present an ensemble algorithm for selection problem to find the k-th smallest element in the unsorted database. We will search the k-th smallest element by using "divide-and-conquer" strategy. We first divide D, the domain…

Quantum Physics · Physics 2007-05-23 Chien-Yuan Chen , Chih-Cheng Hsueh

Second-generation sequencing technologies have replaced array-based technologies and become the default method for genomics and epigenomics analysis. Second-generation sequencing technologies sequence tens of millions of DNA/cDNA fragments…

Methodology · Statistics 2017-02-08 Ping Ma , Nan Zhang , Jianhua Z. Huang , Wenxuan Zhong

Multiple sequence alignment (MSA) has been one of the most important problems in bioinformatics for more decades and it is still heavily examined by many mathematicians and biologists. However, mostly because of the practical motivation of…

Quantitative Methods · Quantitative Biology 2015-11-17 Kristóf Takács

The recent success of large language models (LLMs) has renewed interest in whether recommender systems can achieve similar scaling benefits. Conventional recommenders, dominated by massive embedding tables, tend to plateau as embedding…

Information Retrieval · Computer Science 2025-10-29 Xiaoyu Kong , Leheng Sheng , Junfei Tan , Yuxin Chen , Jiancan Wu , An Zhang , Xiang Wang , Xiangnan He

In high energy physics experiment trigger systems, track segment seeding is a resource consuming function and the primary reason is the computing complexity of the segment finding process. As the Moore's Law is reaching its physical limit,…

Accelerator Physics · Physics 2023-05-18 Jinyuan Wu

Sequencing by tunneling is a next-generation approach to read single-base information using electronic tunneling transverse to the single-stranded DNA (ssDNA) backbone while the latter is translocated through a narrow channel. The original…

Soft Condensed Matter · Physics 2015-09-23 P. Boynton , A. V. Balatsky , I. K. Schuller , M. Di Ventra

Nanopore sequencing of DNA is a single-molecule technique that may achieve long reads, low cost, and high speed with minimal sample preparation and instrumentation. Here, we build on recent progress with respect to nanopore resolution and…

Motivation: Next generation methods of DNA sequencing produce relatively high rate of reading errors, which interfere with de novo genome assembly of newly sequenced organisms and particularly affect the quality of SNP detection important…

Genomics · Quantitative Biology 2019-07-31 Oleg Fokin , Anastasia Bakulina , Igor Seledtsov , Victor Solovyev

Processing sets or other unordered, potentially variable-sized inputs in neural networks is usually handled by aggregating a number of input tensors into a single representation. While a number of aggregation methods already exist from…

Machine Learning · Computer Science 2022-07-05 Sergey Bartunov , Fabian B. Fuchs , Timothy Lillicrap

Most neural-operator surrogates for PDEs inherit from DeepONet-style formulations the requirement that the input function be sampled at a fixed, ordered set of sensors. This assumption limits applicability to problems with variable sensor…

Machine Learning · Computer Science 2026-04-02 Stepan Tretiakov , Xingjian Li , Krishna Kumar

Distributed training of large neural networks is bottlenecked by full-precision gradient communication and by coordinatewise optimizers that ignore the matrix structure of weight tensors. We propose Sign-Muon, a 1-bit, matrix-aware…

Machine Learning · Computer Science 2026-05-19 Neel Mishra , Kushagara Trivedi , Pawan Kumar

The applications of artificial intelligence (AI) are rapidly evolving, and they are also commonly used in safety-critical domains, such as autonomous driving and medical diagnosis, where functional safety is paramount. In AI-driven systems,…

Machine Learning · Computer Science 2024-05-12 Soyed Tuhin Ahmed , Michael Hefenbrock , Mehdi B. Tahoori

This work focuses on the downlink and uplink of large-scale single-cell MU-MIMO systems in which the base station (BS) endowed with $M$ antennas communicates with $K$ single-antenna user equipments (UEs). Particularly, we aim at reducing…

Information Theory · Computer Science 2017-04-05 Houssem Sifaou , Abla Kammoun , Luca Sanguinetti , Mérouane Debbah , Mohamed-Slim Alouini

The rapid growth of microcontroller-based IoT devices has opened up numerous applications, from smart manufacturing to personalized healthcare. Despite the widespread adoption of energy-efficient microcontroller units (MCUs) in the Tiny…

Machine Learning · Computer Science 2024-09-26 Giorgos Armeniakos , Georgios Mentzos , Dimitrios Soudris

Btrim is a fast and lightweight software to trim adapters and low quality regions in reads from ultra high-throughput next-generation sequencing machines. It also can reliably identify barcodes and assign the reads to the original samples.…

Genomics · Quantitative Biology 2024-05-28 Yong Kong

Named entity recognition (NER) is a widely studied task in natural language processing. Recently, a growing number of studies have focused on the nested NER. The span-based methods, considering the entity recognition as a span…

Computation and Language · Computer Science 2021-06-22 Zeqi Tan , Yongliang Shen , Shuai Zhang , Weiming Lu , Yueting Zhuang

Deep neural networks are behind many of the recent successes in machine learning applications. However, these models can produce overconfident decisions while encountering out-of-distribution (OOD) examples or making a wrong prediction.…

Machine Learning · Computer Science 2021-06-24 Navid Kardan , Ankit Sharma , Kenneth O. Stanley