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Current statistical inference problems in areas like astronomy, genomics, and marketing routinely involve the simultaneous testing of thousands -- even millions -- of null hypotheses. For high-dimensional multivariate distributions, these…

Methodology · Statistics 2017-04-25 Weixin Cai , Nima S. Hejazi , Alan E. Hubbard

Large-scale multiple testing with correlated and heavy-tailed data arises in a wide range of research areas from genomics, medical imaging to finance. Conventional methods for estimating the false discovery proportion (FDP) often ignore the…

Methodology · Statistics 2018-09-19 Jianqing Fan , Yuan Ke , Qiang Sun , Wen-Xin Zhou

The knockoff filter of Barber and Candes (arXiv:1404.5609) is a flexible framework for multiple testing in supervised learning models, based on introducing synthetic predictor variables to control the false discovery rate (FDR). Using the…

Methodology · Statistics 2024-11-26 Yixiang Luo , William Fithian , Lihua Lei

Source-Free Unsupervised Domain Adaptation (SFUDA) is a challenging task where a model needs to be adapted to a new domain without access to target domain labels or source domain data. The primary difficulty in this task is that the model's…

Computer Vision and Pattern Recognition · Computer Science 2024-02-05 Yangyang Shu , Xiaofeng Cao , Qi Chen , Bowen Zhang , Ziqin Zhou , Anton van den Hengel , Lingqiao Liu

Controlling the False Discovery Rate (FDR) in a variable selection procedure is critical for reproducible discoveries, and it has been extensively studied in sparse linear models. However, it remains largely open in scenarios where the…

Methodology · Statistics 2023-11-16 Yang Cao , Xinwei Sun , Yuan Yao

Many statistical problems can be addressed by applying a multiple testing procedure (MTP) that controls either the Family-wise Error Rate (FWER) or False Discovery Rate (FDR) under unknown arbitrarily-interdependent $p$-values, without…

Methodology · Statistics 2026-05-21 George Karabatsos

While standard statistical inference techniques and machine learning generalization bounds assume that tests are run on data selected independently of the hypotheses, practical data analysis and machine learning are usually iterative and…

Signal Processing · Electrical Eng. & Systems 2019-10-09 Lorenzo De Stefani , Eli Upfal

Multiple hypothesis testing is a fundamental problem in high dimensional inference, with wide applications in many scientific fields. In genome-wide association studies, tens of thousands of tests are performed simultaneously to find if any…

Methodology · Statistics 2010-12-21 Xu Han , Weijie Gu , Jianqing Fan

A topological multiple testing scheme for one-dimensional domains is proposed where, rather than testing every spatial or temporal location for the presence of a signal, tests are performed only at the local maxima of the smoothed observed…

Statistics Theory · Mathematics 2012-03-15 Armin Schwartzman , Yulia Gavrilov , Robert J. Adler

Results on the false discovery rate (FDR) and the false nondiscovery rate (FNR) are developed for single-step multiple testing procedures. In addition to verifying desirable properties of FDR and FNR as measures of error rates, these…

Statistics Theory · Mathematics 2007-06-13 Sanat K. Sarkar

This manuscript presents the following: (1) an improved version of the Binary Simultaneous Perturbation Stochastic Approximation (SPSA) Method for feature selection in machine learning (Aksakalli and Malekipirbazari, Pattern Recognition…

We introduce a novel method for sparse regression and variable selection, which is inspired by modern ideas in multiple testing. Imagine we have observations from the linear model y = X beta + z, then we suggest estimating the regression…

Methodology · Statistics 2013-10-30 Malgorzata Bogdan , Ewout van den Berg , Weijie Su , Emmanuel Candes

This paper studies the semi-supervised novelty detection problem where a set of "typical" measurements is available to the researcher. Motivated by recent advances in multiple testing and conformal inference, we propose AdaDetect, a…

Methodology · Statistics 2023-10-26 Ariane Marandon , Lihua Lei , David Mary , Etienne Roquain

This research deals with massive multiple hypothesis testing. First regarding multiple tests as an estimation problem under a proper population model, an error measurement called Erroneous Rejection Ratio (ERR) is introduced and related to…

Statistics Theory · Mathematics 2007-06-13 Cheng Cheng

The problem of identifying regions of spatially interesting, different or adversarial behavior is inherent to many practical applications involving distributed multisensor systems. In this work, we develop a general framework stemming from…

Signal Processing · Electrical Eng. & Systems 2022-06-14 Martin Gölz , Abdelhak M. Zoubir , Visa Koivunen

This paper builds on recent developments in Bayesian network (BN) structure learning under the controversial assumption that the input variables are dependent. This assumption can be viewed as a learning constraint geared towards cases…

Machine Learning · Computer Science 2020-06-08 Anthony Constantinou

Some crucial issues about a recently proposed estimator for the proportion of true null hypotheses ($\pi_0$) under discrete setup are discussed. An estimator for $\pi_0$ is introduced under the same setup. The estimator may be seen as a…

Statistics Theory · Mathematics 2020-09-09 Aniket Biswas , Gaurangadeb Chattopadhyay

Variable selection has been widely used in data analysis for the past decades, and it becomes increasingly important in the Big Data era as there are usually hundreds of variables available in a dataset. To enhance interpretability of a…

Methodology · Statistics 2020-08-17 Yuxiang Xie , Kwun Chuen Gary Chan

Standardization has been a widely adopted practice in multiple testing, for it takes into account the variability in sampling and makes the test statistics comparable across different study units. However, despite conventional wisdom to the…

Methodology · Statistics 2020-03-09 Luella Fu , Bowen Gang , Gareth M. James , Wenguang Sun

Motivated by the genomic application of expression quantitative trait loci (eQTL) mapping, we propose a new procedure to perform simultaneous testing of multiple hypotheses using Bayes factors as input test statistics. One of the most…

Methodology · Statistics 2016-06-09 Xiaoquan Wen