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In phylogenetics, tree-based networks are used to model and visualize the evolutionary history of species where reticulate events such as horizontal gene transfer have occurred. Formally, a tree-based network $N$ consists of a phylogenetic…

Discrete Mathematics · Computer Science 2020-08-21 Jonathan Klawitter , Peter Stumpf

A rooted phylogenetic network is a directed acyclic graph with a single root, whose sinks correspond to a set of species. As such networks are useful for representing the evolution of species that have undergone reticulate evolution, there…

Populations and Evolution · Quantitative Biology 2022-06-28 Vincent Moulton , Taoyang Wu

Phylogenetic (i.e. leaf-labeled) trees play a fundamental role in evolutionary research. A typical problem is to reconstruct such trees from data like DNA alignments (whose columns are often referred to as characters), and a simple…

Populations and Evolution · Quantitative Biology 2022-09-08 Mareike Fischer

Background: The reconstruction of the phylogenetic tree topology of four taxa is, still nowadays, one of the main challenges in phylogenetics. Its difficulties lie in considering not too restrictive evolutionary models, and correctly…

Populations and Evolution · Quantitative Biology 2014-06-19 Esther Ibáñez , Marta Casanellas

Phylogenetic trees in genetics and biology in general are all binary. We make an attempt to answer one fundamental question: Is such binary branching from the coarsest to the finest scales sustained by data? We convert this question into an…

Methodology · Statistics 2018-01-29 Tania Roy , Hsieh Fushing , Xunde Li , Brenda McCowan , Rob Atwill

There are several tools available to infer phylogenetic trees, which depict the evolutionary relationships among biological entities such as viral and bacterial strains in infectious outbreaks, or cancerous cells in tumor progression trees.…

Data Structures and Algorithms · Computer Science 2023-12-22 António Pedro Branco , Cátia Vaz , Alexandre P. Francisco

Semi-labeled trees are phylogenies whose internal nodes may be labeled by higher-order taxa. Thus, a leaf labeled Mus musculus could nest within a subtree whose root node is labeled Rodentia, which itself could nest within a subtree whose…

Data Structures and Algorithms · Computer Science 2016-05-09 Yun Deng , David Fernández-Baca

Deciding whether a collection of unrooted trees is compatible is a fundamental problem in phylogenetics. Two different graph-theoretic characterizations of tree compatibility have recently been proposed. In one of these, tree compatibility…

Discrete Mathematics · Computer Science 2012-10-16 Sudheer Vakati , David Fernández-Baca

Phylogenetic networks are an important way to represent evolutionary histories that involve reticulations such as hybridization or horizontal gene transfer, yet fundamental questions such as how many networks there are that satisfy certain…

Populations and Evolution · Quantitative Biology 2025-02-21 Andrew Francis , Michael Hendriksen

Classification of gene trees is an important task both in the analysis of multi-locus phylogenetic data, and assessment of the convergence of Markov Chain Monte Carlo (MCMC) analyses used in Bayesian phylogenetic tree reconstruction. The…

Combinatorics · Mathematics 2024-06-10 Georgios Aliatimis , Ruriko Yoshida , Burak Boyaci , James A. Grant

Tree containment problem is a fundamental problem in phylogenetic study, as it is used to verify a network model. It asks whether a given network contain a subtree that resembles a binary tree. The problem is NP-complete in general, even in…

Populations and Evolution · Quantitative Biology 2017-02-15 Andreas Gunawan

Tree structures appear in many fields of the life sciences, including phylogenetics, developmental biology and nucleic acid structures. Trees can be used to represent RNA secondary structures, which directly relate to the function of…

Machine Learning · Computer Science 2026-01-22 Pengyu Liu , Mariel Vázquez , Nataša Jonoska

Phylogenetic (evolutionary) trees and networks are leaf-labeled graphs that are widely used to represent the evolutionary relationships between entities such as species, languages, cancer cells, and viruses. To reconstruct and analyze…

Data Structures and Algorithms · Computer Science 2023-08-21 Michael J. Dinneen , Pankaj S. Ghodla , Simone Linz

Phylogenetic networks are notoriously difficult to reconstruct. Here we suggest that it can be useful to view unknown genetic distance along edges in phylogenetic networks as analogous to unknown resistance in electric circuits. This…

Combinatorics · Mathematics 2020-10-01 Stefan Forcey , Drew Scalzo

Jansson and Sung showed that, given a dense set of input triplets T (representing hypotheses about the local evolutionary relationships of triplets of species), it is possible to determine in polynomial time whether there exists a level-1…

Populations and Evolution · Quantitative Biology 2007-07-20 Leo van Iersel , Judith Keijsper , Steven Kelk , Leen Stougie

The history of gene families -- which are equivalent to event-labeled gene trees -- can to some extent be reconstructed from empirically estimated evolutionary event-relations containing pairs of orthologous, paralogous or xenologous genes.…

Discrete Mathematics · Computer Science 2019-10-30 Manuel Lafond , Marc Hellmuth

In evolutionary biology, phylogenetic networks are graphs that provide a flexible framework for representing complex evolutionary histories that involve reticulate evolutionary events. Recently phylogenetic studies have started to focus on…

Populations and Evolution · Quantitative Biology 2025-11-17 Niels Holtgrefe , Katharina T. Huber , Leo van Iersel , Mark Jones , Vincent Moulton

Phylogenetic tree comparison metrics are an important tool in the study of evolution, and hence the definition of such metrics is an interesting problem in phylogenetics. In a paper in Taxon fifty years ago, Sokal and Rohlf proposed to…

Populations and Evolution · Quantitative Biology 2013-01-22 Gabriel Cardona , Arnau Mir , Francesc Rossello , Lucia Rotger , David Sanchez

Phylogenetic networks are a flexible model of evolution that can represent reticulate evolution and handle complex data. Tree-based networks, which are phylogenetic networks that have a spanning tree with the same root and leaf-set as the…

Combinatorics · Mathematics 2023-05-25 Takatora Suzuki , Han Guo , Momoko Hayamizu

Interest in the inference of evolutionary networks relating species or populations has grown with the increasing recognition of the importance of hybridization, gene flow and admixture, and the availability of large-scale genomic data.…

Populations and Evolution · Quantitative Biology 2024-07-23 John A. Rhodes , Hector Banos , Jingcheng Xu , Cécile Ané