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Recent genomic and bioinformatic advances have motivated the development of numerous random network models purporting to describe graphs of biological, technological, and sociological origin. The success of a model has been evaluated by how…

Molecular Networks · Quantitative Biology 2007-05-23 Manuel Middendorf , Etay Ziv , Carter Adams , Jen Hom , Robin Koytcheff , Chaya Levovitz , Gregory Woods , Linda Chen , Chris Wiggins

We analyze the structure of two dimensional disordered cellular systems generated by extensive computer simulations. These cellular structures are studied as topological trees rooted on a central cell or as closed shells arranged…

Disordered Systems and Neural Networks · Physics 2009-10-30 H. M. Ohlenbusch , T. Aste , B. Dubertret , N. Rivier

The theory of $G$-structures provides us with a unified framework for a large class of geometric structures, including symplectic, complex and Riemannian structures, as well as foliations and many others. Surprisingly, contact geometry -…

Differential Geometry · Mathematics 2020-03-10 Alfonso G. Tortorella , Luca Vitagliano , Ori Yudilevich

Understanding the base pairing of an RNA sequence provides insight into its molecular structure.By mining suboptimal sampling data, RNAprofiling 1.0 identifies the dominant helices in low-energy secondary structures as features, organizes…

Biomolecules · Quantitative Biology 2023-03-29 Forrest Hurley , Christine Heitsch

Understanding the biological function of knots in proteins and their folding process is an open and challenging question in biology. Recent studies classify the topology and geometry of knotted proteins by analysing the distribution of a…

The ongoing effort to detect and characterize physical entanglement in biopolymers has so far established that knots are present in many globular proteins and also abound in viral DNA packaged inside bacteriophages. RNA molecules, on the…

Biomolecules · Quantitative Biology 2014-10-08 Cristian Micheletti , Marco Di Stefano , Henri Orland

Evolutionary mechanism in a self-organized system cause some functional changes that force to adapt new conformation of the interaction pattern between the components of that system. Measuring the structural differences one can retrace the…

Quantitative Methods · Quantitative Biology 2012-10-19 Anirban Banerjee

We study the richness of the ensemble of graphical structures (i.e., unlabeled graphs) of the one-dimensional random geometric graph model defined by $n$ nodes randomly scattered in $[0,1]$ that connect if they are within the connection…

Information Theory · Computer Science 2022-06-24 Mihai-Alin Badiu , Justin P. Coon

In this paper we study canonical $\gamma$-structures, a class of RNA pseudoknot structures that plays a key role in the context of polynomial time folding of RNA pseudoknot structures. A $\gamma$-structure is composed by specific building…

Combinatorics · Mathematics 2013-09-05 Hillary S. W. Han , Thomas J. X. Li , Christian M. Reidys

Chromosomes are crumpled polymer chains further folded into a sequence of stochastic loops via loop extrusion. While extrusion has been verified experimentally, the particular means by which the extruding complexes bind DNA polymer remains…

Soft Condensed Matter · Physics 2023-06-14 Kirill Polovnikov , Bogdan Slavov

We consider the dynamics of a reaction-diffusion system on a multigraph. The species share the same set of nodes but can access different links to explore the embedding spatial support. By acting on the topology of the networks we can…

Statistical Mechanics · Physics 2016-12-21 Malbor Asllani , Timoteo Carletti , Duccio Fanelli

The recent discovery of universal principles underlying many complex networks occurring across a wide range of length scales in the biological world has spurred physicists in trying to understand such features using techniques from…

Biological Physics · Physics 2015-05-13 Sitabhra Sinha

A lattice model of RNA denaturation which fully accounts for the excluded volume effects among nucleotides is proposed. A numerical study shows that interactions forming pseudoknots must be included in order to get a sharp continuous…

Soft Condensed Matter · Physics 2007-05-23 M. Baiesi , E. Orlandini , A. L. Stella

We develop topological methods for analyzing difference topology experiments involving 3-string tangles. Difference topology is a novel technique used to unveil the structure of stable protein-DNA complexes involving two or more DNA…

Geometric Topology · Mathematics 2016-01-20 Isabel K. Darcy , John Luecke , Mariel Vazquez

One property of networks that has received comparatively little attention is hierarchy, i.e., the property of having vertices that cluster together in groups, which then join to form groups of groups, and so forth, up through all levels of…

Physics and Society · Physics 2008-04-12 Aaron Clauset , Cristopher Moore , M. E. J. Newman

We study low-dimensional problems in topology and geometry via a study of contact and Cauchy-Riemann ($CR$) structures. A contact structure is called spherical if it admits a compatible spherical $CR$ structure. We will talk about spherical…

Symplectic Geometry · Mathematics 2007-05-23 Jih-Hsin Cheng

The observation, design and analysis of mesh-like networks in bionics, polymer physics and biological systems has brought forward an extensive catalog of fascinating structures of which a subgroup share a particular, yet critically under…

Tissues and Organs · Quantitative Biology 2023-08-08 Felix Kramer , Carl D Modes

We explore the interplay between the topological relevance of a neuron and its dynamical traces in experimental cultured neuronal networks. We monitor the growth and development of these networks to characterise the evolution of their…

Adaptation and Self-Organizing Systems · Physics 2023-07-14 A. Tlaie , L. M. Ballesteros-Esteban , I. Leyva , I. Sendina-Nadal

The three dimensional structure of DNA in the nucleus (chromatin) plays an important role in many cellular processes. Recent experimental advances have led to high-throughput methods of capturing information about chromatin conformation on…

Genomics · Quantitative Biology 2015-11-05 Kevin Emmett , Benjamin Schweinhart , Raul Rabadan

In this paper, we study some topological characteristics of the n-normed spaces. We observe convergence sequences, closed sets, and bounded sets in the n-normed spaces using norms of quotient spaces that will be constructed. These norms…

Functional Analysis · Mathematics 2018-10-19 Harmanus Batkunde , Hendra Gunawan