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We tested the hypothesis that the neural code of retinal ganglion cells is optimized to transmit visual information at minimal metabolic cost. Under a broad ensemble of light patterns, ganglion cell spike trains consisted of sparse, precise…

Soft Condensed Matter · Physics 2007-05-23 Vijay Balasubramanian , Michael J Berry

Recordings in the human medial temporal lobe have found many neurons that respond to pictures (and related stimuli) of just one particular person out of those presented. It has been proposed that these are concept cells, responding to just…

Neurons and Cognition · Quantitative Biology 2015-07-22 Andrew Magyar , John Collins

We revisit and extend model stitching (Lenc & Vedaldi 2015) as a methodology to study the internal representations of neural networks. Given two trained and frozen models $A$ and $B$, we consider a "stitched model'' formed by connecting the…

Machine Learning · Computer Science 2021-06-16 Yamini Bansal , Preetum Nakkiran , Boaz Barak

Identifying the principles that determine neural population activity is paramount in the field of neuroscience. We propose the Principle of Isomorphism (PIso): population activity preserves the essential mathematical structures of the tasks…

Neurons and Cognition · Quantitative Biology 2025-10-17 Maoshen Xu , Fei Song , Yuxiu Shao , Bailu Si , Shanshan Qin

Understanding how receptive fields emerge and organize within brain networks and how neural dynamics couple with stimuli space is fundamental to neuroscience. Models often rely on fine-tuning connectivity to match empirical data, which may…

Neurons and Cognition · Quantitative Biology 2026-01-07 Vasilii Tiselko , Alexander Gorsky , Yuri Dabaghian

Understanding the dynamical behavior of complex systems from their underlying network architectures is a long-standing question in complexity theory. Therefore, many metrics have been devised to extract network features like motifs,…

Neurons and Cognition · Quantitative Biology 2024-09-05 Bryant Avila , Pedro Augusto , David Phillips , Tommaso Gili , Manuel Zimmer , Hernán A. Makse

This paper introduces the Gene Mover's Distance, a measure of similarity between a pair of cells based on their gene expression profiles obtained via single-cell RNA sequencing. The underlying idea of the proposed distance is to interpret…

Genomics · Quantitative Biology 2021-03-16 Riccardo Bellazzi , Andrea Codegoni , Stefano Gualandi , Giovanna Nicora , Eleonora Vercesi

We seek to characterize the motility of mouse fibroblasts on 2D substrates. Utilizing automated tracking techniques, we find that cell trajectories are super-diffusive, where displacements scale faster than t^(1/2) in all directions. Two…

Soft Condensed Matter · Physics 2017-12-15 G Passucci , ME Brasch , JH Henderson , V Zaburdaev , ML Manning

In deep learning, optimization plays a vital role. By focusing on image classification, this work investigates the pros and cons of the widely used optimizers, and proposes a new optimizer: Perturbated Unit Gradient Descent (PUGD) algorithm…

Machine Learning · Computer Science 2022-11-10 Ching-Hsun. Tseng , Liu-Hsueh. Cheng , Shin-Jye. Lee , Xiaojun Zeng

Recent work suggests goal-driven training of neural networks can be used to model neural activity in the brain. While response properties of neurons in artificial neural networks bear similarities to those in the brain, the network…

Neurons and Cognition · Quantitative Biology 2020-05-19 Christopher J. Cueva , Peter Y. Wang , Matthew Chin , Xue-Xin Wei

In solving partial differential equations (PDEs), machine learning utilizing physical laws has received considerable attention owing to advantages such as mesh-free solutions, unsupervised learning, and feasibility for solving…

Machine Learning · Computer Science 2026-03-25 Tetsuro Tsuchino , Motoki Shiga

Quian Quiroga et al. [Nature 435, 1102 (2005)] have recently discovered neurons that appear to have the characteristics of grandmother (GM) cells. Here we quantitatively assess the compatibility of their data with the GM-cell hypothesis. We…

Neurons and Cognition · Quantitative Biology 2007-05-23 John Collins , Dezhe Z. Jin

Self-sustained, elevated neuronal activity persisting on time scales of ten seconds or longer is thought to be vital for aspects of working memory, including brain representations of real space. Continuous-attractor neural networks, one of…

Neurons and Cognition · Quantitative Biology 2020-08-19 Joseph L. Natale , H. George E. Hentschel , Ilya Nemenman

Neuroscientists classify neurons into different types that perform similar computations at different locations in the visual field. Traditional methods for neural system identification do not capitalize on this separation of 'what' and…

Machine Learning · Statistics 2018-01-30 David A. Klindt , Alexander S. Ecker , Thomas Euler , Matthias Bethge

During the last decades, many studies have been dedicated to improving the performance of neural networks, for example, the network architectures, initialization, and activation. However, investigating the importance and effects of…

Computer Vision and Pattern Recognition · Computer Science 2023-01-12 Fahad Alrasheedi , Xin Zhong , Pei-Chi Huang

Modeling place functions from a computational perspective is a prevalent research topic. Trajectory embedding, as a neural-network-backed dimension reduction technology, allows the possibility to put places with similar social functions at…

Artificial Intelligence · Computer Science 2020-12-15 Cheng Fu , Robert Weibel

The localization of self-driving cars is needed for several tasks such as keeping maps updated, tracking objects, and planning. Localization algorithms often take advantage of maps for estimating the car pose. Since maintaining and using…

The high computational complexity and increasing parameter counts of deep neural networks pose significant challenges for deployment in resource-constrained environments, such as edge devices or real-time systems. To address this, we…

Machine Learning · Computer Science 2025-06-17 Laura Erb , Tommaso Boccato , Alexandru Vasilache , Juergen Becker , Nicola Toschi

With the rise of big data analytics, multi-layer neural networks have surfaced as one of the most powerful machine learning methods. However, their theoretical mathematical properties are still not fully understood. Training a neural…

Machine Learning · Computer Science 2021-01-01 Victor Luo , Yazhen Wang , Glenn Fung

Interactions between crawling cells, which are essential for many biological processes, can be quantified by measuring cell-cell collisions. Conventionally, experiments of cell-cell collisions are conducted on two-dimensional flat…

Biological Physics · Physics 2025-10-24 Yongtian Luo , Amrinder S. Nain , Brian A. Camley
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