Related papers: A rigorous sharp interface limit of a diffuse inte…
Tumor growth beyond a critical size relies on the development of a functional vascular network, which ensures adequate oxygen and nutrient supply. In this work, we present a modeling framework based on an optimization-based 3D-1D coupling…
We investigate the sharp material interface limit of the Darcy-Boussinesq model for convection in layered porous media with diffused material interfaces, which allow a gradual transition of material parameters between different layers. We…
In this survey article, a variety of systems modeling tumor growth are discussed. In accordance with the hallmarks of cancer, the described models incorporate the primary characteristics of cancer evolution. Specifically, we focus on…
We consider a continuum mechanical model of cell invasion through thin membranes. The model consists of a transmission problem for cell volume fraction complemented with continuity of stresses and mass flux across the surfaces of the…
We investigate avascular tumour growth as a two-phase process consisting of cells and liquid. Based on the one-dimensional continuum moving-boundary model formulated by (Byrne, King, McElwain, Preziosi, Applied Mathematics Letters, 2003,…
A nutrient-limited model for avascular cancer growth including cell proliferation, motility and death is presented. The model qualitatively reproduces commonly observed morphologies for primary tumors, and the simulated patterns are…
This paper concerns multiphase models of tumor growth in interaction with a surrounding tissue, taking into account also the interplay with diffusible nutrients feeding the cells. Models specialize in nonlinear systems of possibly…
In the present article the diffusion equation is used to model the spatio-temporal dynamics of a tumor, taking into account the heterogeneous of the medium. This approach makes it possible to take into account the complex geometric shape of…
In this work, we present a phase-field model for tumour growth, where a diffuse interface separates a tumour from the surrounding host tissue. In our model, we consider transport processes by an internal, non-solenoidal velocity field. We…
We investigate the dynamics of a nonlinear system modeling tumor growth with drug application. The tumor is viewed as a mixture consisting of proliferating, quiescent and dead cells as well as a nutrient in the presence of a drug. The…
We formulate a general shape and topology optimization problem in structural optimization by using a phase field approach. This problem is considered in view of well-posedness and we derive optimality conditions. We relate the diffuse…
A thermodynamic approach to rapid phase transformations within a diffuse interface in a binary system is developed. Assuming an extended set of independent thermodynamic variables formed by the union of the classic set of slow variables and…
We investigate the general Porous Medium Equations with drift and source terms that model tumor growth. Incompressible limit of such models has been well-studied in the literature, where convergence of the density and pressure variables are…
We consider the sharp interface limit of a coupled Stokes/Allen-Cahn system, when a parameter $\varepsilon>0$ that is proportional to the thickness of the diffuse interface tends to zero, in a two dimensional bounded domain. For…
In this work, we study a model consisting of a Cahn-Hilliard-type equation for the concentration of tumour cells coupled to a reaction-diffusion type equation for the nutrient density and a Brinkman-type equation for the velocity. We equip…
In this work, we present and analyze a mathematical model for tumor growth incorporating ECM erosion, interstitial flow, and the effect of vascular flow and nutrient transport. The model is of phase-field or diffused-interface type in which…
In this letter, we derive the sharp-interface limit of the Cahn-Hilliard-Biot equations using formal matched asymptotic expansions. We find that in each sub-domain, the quasi-static Biot equations are obtained with domain-specific material…
The dynamics of compressible liquid-vapor flow depends sensitively on the microscale behavior at the phase boundary. We consider a sharp-interface approach, and propose a multiscale model to describe liquid-vapor flow accurately, without…
Various models of tumor growth are available in the litterature. A first class describes the evolution of the cell number density when considered as a continuous visco-elastic material with growth. A second class, describes the tumor as a…
We consider a fully practical finite element approximation of a diffuse interface model for tumour growth that takes the form of a degenerate parabolic system. In addition to showing stability bounds for the approximation, we prove…