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Network control theory has recently emerged as a promising approach for understanding brain function and dynamics. By operationalizing notions of control theory for brain networks, it offers a fundamental explanation for how brain dynamics…

Quantitative Methods · Quantitative Biology 2020-03-20 Shikuang Deng , Shi Gu

Cognitive function is driven by dynamic interactions between large-scale neural circuits or networks, enabling behavior. Fundamental principles constraining these dynamic network processes have remained elusive. Here we use network control…

Neurons and Cognition · Quantitative Biology 2015-10-28 Shi Gu , Fabio Pasqualetti , Matthew Cieslak , Scott T. Grafton , Danielle S. Bassett

Recent work suggests goal-driven training of neural networks can be used to model neural activity in the brain. While response properties of neurons in artificial neural networks bear similarities to those in the brain, the network…

Neurons and Cognition · Quantitative Biology 2020-05-19 Christopher J. Cueva , Peter Y. Wang , Matthew Chin , Xue-Xin Wei

Contemporary neuroscience has embraced network science to study the complex and self-organized structure of the human brain; one of the main outstanding issues is that of inferring from measure data, chiefly functional Magnetic Resonance…

Optimization and Control · Mathematics 2017-03-31 Giulia Prando , Mattia Zorzi , Alessandra Bertoldo , Alessandro Chiuso

Brain activity is intrinsically a neural dynamic process constrained by anatomical space. This leads to significant variations in spatial distribution patterns and correlation patterns of neural activity across variable and heterogeneous…

Machine Learning · Computer Science 2026-03-10 Hongjie Jiang , Yifei Tang , Shuqiang Wang

Starting from the morphological-functional assumption of the fractal brain, a mathematical model is given by activating brain non-differentiable dynamics through the determinism-nondeterminism inference of the responsible mechanisms. The…

Neurons and Cognition · Quantitative Biology 2015-11-18 Maricel Agop , Alina Gavrilut , Gabriel Crumpei , Mitica Craus , Vlad Birlescu

Applications of neuroimaging methods have substantially contributed to the scientific understanding of human factors during driving by providing a deeper insight into the neuro-cognitive aspects of driver brain. This has been achieved by…

Human-Computer Interaction · Computer Science 2020-07-21 Milad Haghani , Michiel C. J. Bliemer , Bilal Farooq , Inhi Kim , Zhibin Li , Cheol Oh , Zahra Shahhoseini , Hamish MacDougall

Anatomic connections between brain areas affect information flow between neuronal circuits and the synchronization of neuronal activity. However, such structural connectivity does not coincide with effective connectivity, related to the…

Neurons and Cognition · Quantitative Biology 2015-06-03 Demian Battaglia , Annette Witt , Fred Wolf , Theo Geisel

Understanding neurocognitive computations will require not just localizing cognitive information distributed throughout the brain but also determining how that information got there. We review recent advances in linking empirical and…

Neurons and Cognition · Quantitative Biology 2019-10-22 Takuya Ito , Luke Hearne , Ravi Mill , Carrisa Cocuzza , Michael W. Cole

The relation between large-scale brain structure and function is an outstanding open problem in neuroscience. We approach this problem by studying the dynamical regime under which realistic spatio-temporal patterns of brain activity emerge…

Neurons and Cognition · Quantitative Biology 2014-05-27 Ariel Haimovici , Enzo Tagliazucchi , Pablo Balenzuela , Dante R. Chialvo

The study of random networks in a neuroscientific context has developed extensively over the last couple of decades. By contrast, techniques for the statistical analysis of these networks are less developed. In this paper, we focus on the…

Neurons and Cognition · Quantitative Biology 2017-07-11 Daniel Fraiman , Ricardo Fraiman

Knowing brain connectivity is of great importance both in basic research and for clinical applications. We are proposing a method to infer directed connectivity from zero-lag covariances of neuronal activity recorded at multiple sites. This…

Neurons and Cognition · Quantitative Biology 2018-04-10 Jonathan Schiefer , Alexander Niederbühl , Volker Pernice , Carolin Lennartz , Pierre LeVan , Jürgen Henning , Stefan Rotter

Neural activity fluctuates over a wide range of timescales within and across brain areas. Experimental observations suggest that diverse neural timescales reflect information in dynamic environments. However, how timescales are defined and…

Neurons and Cognition · Quantitative Biology 2026-01-21 Roxana Zeraati , Anna Levina , Jakob H. Macke , Richard Gao

Brain-computer interfaces (BCIs) make possible to interact with the external environment by decoding the mental intention of individuals. BCIs can therefore be used to address basic neuroscience questions but also to unlock a variety of…

Neurons and Cognition · Quantitative Biology 2021-02-12 Juliana Gonzalez-Astudillo , Tiziana Cattai , Giulia Bassignana , Marie-Constance Corsi , Fabrizio De Vico Fallani

Dynamic functional connectivity is an effective measure for the brain's responses to continuous stimuli. We propose an inferential method to detect the dynamic changes of brain networks based on time-varying graphical models. Whereas most…

Applications · Statistics 2020-06-23 Dingjue Ji , Junwei Lu , Yiliang Zhang , Hongyu Zhao , Siyuan Gao

Neural circuits comprise multiple interconnected regions, each with complex dynamics. The interplay between local and global activity is thought to underlie computational flexibility, yet the structure of multiregion neural activity and its…

Neurons and Cognition · Quantitative Biology 2025-01-09 David G. Clark , Manuel Beiran

The brain is in a state of perpetual reverberant neural activity, even in the absence of specific tasks or stimuli. Shedding light on the origin and functional significance of such a dynamical state is essential to understanding how the…

Statistical Mechanics · Physics 2022-07-08 Guillermo B. Morales , Serena Di Santo , Miguel A. Munoz

A diverse white matter network and finely tuned neuronal membrane properties allow the brain to transition seamlessly between cognitive states. However, it remains unclear how static structural connections guide the temporal progression of…

Cortical neurons emit seemingly erratic trains of action potentials or "spikes," and neural network dynamics emerge from the coordinated spiking activity within neural circuits. These rich dynamics manifest themselves in a variety of…

Neurons and Cognition · Quantitative Biology 2022-04-01 Braden A. W. Brinkman , Han Yan , Arianna Maffei , Il Memming Park , Alfredo Fontanini , Jin Wang , Giancarlo La Camera

A central challenge in the computational modeling of neural dynamics is the trade-off between accuracy and simplicity. At the level of individual neurons, nonlinear dynamics are both experimentally established and essential for neuronal…