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This study investigates the impact of masking strategies on time series imputation models in healthcare settings. While current approaches predominantly rely on random masking for model evaluation, this practice fails to capture the…

Machine Learning · Computer Science 2025-02-05 Linglong Qian , Yiyuan Yang , Wenjie Du , Jun Wang , Richard Dobsoni , Zina Ibrahim

Multimodal clinical records contain structured measurements and clinical notes recorded over time, offering rich temporal information about the evolution of patient health. Yet these observations are sparse, and whether they are recorded…

Machine Learning · Computer Science 2026-04-24 Zihan Liang , Ziwen Pan , Ruoxuan Xiong

Time series models with recurrent neural networks (RNNs) can have high accuracy but are unfortunately difficult to interpret as a result of feature-interactions, temporal-interactions, and non-linear transformations. Interpretability is…

Machine Learning · Computer Science 2021-09-17 Asif Rahman , Yale Chang , Jonathan Rubin

Observations made in continuous time are often irregular and contain the missing values across different channels. One approach to handle the missing data is imputing it using splines, by fitting the piecewise polynomials to the observed…

Machine Learning · Computer Science 2022-10-20 Marin Biloš , Emanuel Ramneantu , Stephan Günnemann

Multivariate bounded discrete data arises in many fields. In the setting of dementia studies, such data is collected when individuals complete neuropsychological tests. We outline a modeling and inference procedure that can model the joint…

Methodology · Statistics 2026-02-10 Daniel Suen , Yen-Chi Chen

Healthcare data frequently contain a substantial proportion of missing values, necessitating effective time series imputation to support downstream disease diagnosis tasks. However, existing imputation methods focus on discrete data points…

Machine Learning · Computer Science 2025-05-19 Mengxuan Li , Ke Liu , Jialong Guo , Jiajun Bu , Hongwei Wang , Haishuai Wang

Most practical data science problems encounter missing data. A wide variety of solutions exist, each with strengths and weaknesses that depend upon the missingness-generating process. Here we develop a theoretical framework for training and…

Machine Learning · Computer Science 2022-11-15 Jahan C. Penny-Dimri , Christoph Bergmeir , Julian Smith

Established recurrent neural networks are well-suited to solve a wide variety of prediction tasks involving discrete sequences. However, they do not perform as well in the task of dynamical system identification, when dealing with…

Machine Learning · Computer Science 2019-11-22 Thomas Demeester

Detecting anomalies in temporal data has gained significant attention across various real-world applications, aiming to identify unusual events and mitigate potential hazards. In practice, situations often involve a mix of segment-level…

Machine Learning · Computer Science 2025-01-22 Yaxuan Wang , Hao Cheng , Jing Xiong , Qingsong Wen , Han Jia , Ruixuan Song , Liyuan Zhang , Zhaowei Zhu , Yang Liu

Linear quantile regression models aim at providing a detailed and robust picture of the (conditional) response distribution as function of a set of observed covariates. Longitudinal data represent an interesting field of application of such…

Methodology · Statistics 2015-07-30 Maria Francesca Marino , Nikos Tzavidis , Marco Alfo'

In this paper, we consider a new low-quality label learning problem: learning time series detection models from temporally imprecise labels. In this problem, the data consist of a set of input time series, and supervision is provided by a…

Machine Learning · Statistics 2017-04-14 Roy J. Adams , Benjamin M. Marlin

Data collected in clinical trials are often composed of multiple types of variables. For example, laboratory measurements and vital signs are longitudinal data of continuous or categorical variables, adverse events may be recurrent events,…

Methodology · Statistics 2023-01-12 Tuo Wang , Rachel Zilinskas , Ying Li , Yongming Qu

Obesity is a serious public health concern world-wide, which increases the risk of many diseases, including hypertension, stroke, and type 2 diabetes. To tackle this problem, researchers across the health ecosystem are collecting diverse…

Machine Learning · Computer Science 2018-09-24 Qinghan Xue , Xiaoran Wang , Samuel Meehan , Jilong Kuang , Alex Gao , Mooi Choo Chuah

Deep neural networks have shown promising results for various clinical prediction tasks. However, training deep networks such as those based on Recurrent Neural Networks (RNNs) requires large labeled data, significant hyper-parameter tuning…

Machine Learning · Computer Science 2021-03-05 Priyanka Gupta , Pankaj Malhotra , Jyoti Narwariya , Lovekesh Vig , Gautam Shroff

Learning temporal patterns from multivariate longitudinal data is challenging especially in cases when data is sporadic, as often seen in, e.g., healthcare applications where the data can suffer from irregularity and asynchronicity as the…

Machine Learning · Computer Science 2021-04-09 Mostafa Mehdipour Ghazi , Lauge Sørensen , Sébastien Ourselin , Mads Nielsen

Health economic evaluations based on patient-level data collected alongside clinical trials~(e.g. health related quality of life and resource use measures) are an important component of the process which informs resource allocation…

Applications · Statistics 2020-05-25 Andrea Gabrio , Rachael Hunter , Alexina J. Mason , Gianluca Baio

Extracting actionable insight from Electronic Health Records (EHRs) poses several challenges for traditional machine learning approaches. Patients are often missing data relative to each other; the data comes in a variety of modalities,…

Machine Learning · Computer Science 2018-11-13 Brandon Malone , Alberto Garcia-Duran , Mathias Niepert

In causal inference, interference occurs when the treatment of one unit may affect the outcomes of other units. The goal of this work is to serve as a guide to the use of linear outcome modeling for estimating causal effects in settings…

Methodology · Statistics 2026-04-01 Eric Tong , Salvador V. Balkus

Missing data scenarios are very common in ML applications in general and time-series/sequence applications are no exceptions. This paper pertains to a novel Recurrent Neural Network (RNN) based solution for sequence prediction under missing…

Machine Learning · Computer Science 2022-08-19 Soumen Pachal , Avinash Achar

Irregularly sampled time series are increasingly prevalent, particularly in medical domains. While various specialized methods have been developed to handle these irregularities, effectively modeling their complex dynamics and pronounced…

Machine Learning · Computer Science 2023-11-01 Zekun Li , Shiyang Li , Xifeng Yan