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In motor neuroscience, artificial recurrent neural networks models often complement animal studies. However, most modeling efforts are limited to data-fitting, and the few that examine virtual embodied agents in a reinforcement learning…

Neurons and Cognition · Quantitative Biology 2023-05-19 Eugene R. Rush , Kaushik Jayaram , J. Sean Humbert

Experimental and numerical results suggest that the brain can be viewed as a system acting close to a critical point, as confirmed by scale-free distributions of relevant quantities in a variety of different systems and models. Less…

Neurons and Cognition · Quantitative Biology 2020-11-25 Dario Raimo , Alessandro Sarracino , Lucilla de Arcangelis

Electrical brain stimulation relies on externally applied currents to modulate neural activity, but safety constraints require each stimulation cycle to be charge-balanced, enforcing a zero net injected charge. However, how such…

Systems and Control · Electrical Eng. & Systems 2025-12-09 Yuzhen Qin , Zonglin Liu , Marcel van Gerven

Recurrent neural networks with balanced excitation and inhibition exhibit irregular asynchronous dynamics, which is fundamental for cortical computations. Classical balance mechanisms require strong external inputs to sustain finite firing…

Neurons and Cognition · Quantitative Biology 2025-10-21 David Angulo-Garcia , Alessandro Torcini

An increasing body of evidence suggests that the trial-to-trial variability of spiking activity in the brain is not mere noise, but rather the reflection of a sampling-based encoding scheme for probabilistic computing. Since the precise…

Living systems process sensory data to facilitate adaptive behaviour. A given sensor can be stimulated as the result of internally driven activity, or by purely external (environmental) sources. It is clear that these inputs are processed…

Neural and Evolutionary Computing · Computer Science 2022-05-16 James Garner , Matthew Egbert

The relation between neural activity and behaviorally relevant variables is at the heart of neuroscience research. When strong, this relation is termed a neural representation. There is increasing evidence, however, for partial…

Neurons and Cognition · Quantitative Biology 2024-08-05 Friedrich Schuessler , Francesca Mastrogiuseppe , Srdjan Ostojic , Omri Barak

All cognitive agents are composite beings. Specifically, complex living agents consist of cells, which are themselves competent sub-agents navigating physiological and metabolic spaces. Behavior science, evolutionary developmental biology,…

Populations and Evolution · Quantitative Biology 2022-11-17 Leo Pio-Lopez , Johanna Bischof , Jennifer V. LaPalme , Michael Levin

We combine power functional theory and machine learning to study non-equilibrium overdamped many-body systems of colloidal particles at the level of one-body fields. We first sample in steady state the one-body fields relevant for the…

Soft Condensed Matter · Physics 2024-10-16 Toni Zimmerman , Florian Sammüller , Sophie Hermann , Matthias Schmidt , Daniel de las Heras

The dynamics of complex systems generally include high-dimensional, non-stationary and non-linear behavior, all of which pose fundamental challenges to quantitative understanding. To address these difficulties we detail a new approach based…

Quantitative Methods · Quantitative Biology 2020-09-11 Antonio Carlos Costa , Tosif Ahamed , Greg J. Stephens

Anatomic connections between brain areas affect information flow between neuronal circuits and the synchronization of neuronal activity. However, such structural connectivity does not coincide with effective connectivity, related to the…

Neurons and Cognition · Quantitative Biology 2015-06-03 Demian Battaglia , Annette Witt , Fred Wolf , Theo Geisel

Understanding active matter has led to new perspectives on biophysics and non-equilibrium dynamics. However, the development of numerical tools for simulating active fluids capable of incorporating non-trivial boundaries or inclusions has…

Soft Condensed Matter · Physics 2024-02-01 Timofey Kozhukhov , Benjamin Loewe , Tyler N. Shendruk

The human brain is autonomously active. To understand the functional role of this self-sustained neural activity, and its interplay with the sensory data input stream, is an important question in cognitive system research and we review here…

Neurons and Cognition · Quantitative Biology 2009-03-03 Claudius Gros

Recent experiments suggested that homeostatic regulation of synaptic balance leads the visual system to recover and maintain a regime of power-law avalanches. Here we study an excitatory/inhibitory (E/I) mean-field neuronal network that has…

Adaptation and Self-Organizing Systems · Physics 2020-02-24 Mauricio Girardi-Schappo , Ludmila Brochini , Ariadne A. Costa , Tawan T. A. Carvalho , Osame Kinouchi

Biological neural networks are notoriously hard to model due to their stochastic behavior and high dimensionality. We tackle this problem by constructing a dynamical model of both the expectations and covariances of the fractions of active…

Neurons and Cognition · Quantitative Biology 2025-02-25 Vincent Painchaud , Patrick Desrosiers , Nicolas Doyon

We review how sensorimotor control is dictated by interacting neural populations, optimal feedback mechanisms, and the biomechanics of bodies. First, we outline the distributed anatomical loops that shuttle sensorimotor signals between…

Neurons and Cognition · Quantitative Biology 2025-09-19 Muhammad Noman Almani , John Lazzari , Jeff Walker , Shreya Saxena

Deciphering the underpinnings of the dynamical processes leading to information transmission, processing, and storing in the brain is a crucial challenge in neuroscience. An inspiring but speculative theoretical idea is that such dynamics…

Statistical Mechanics · Physics 2023-07-21 Guillermo B. Morales , Serena Di Santo , Miguel A. Muñoz

Human brain dynamics can be profitably viewed through the lens of statistical mechanics, where neurophysiological activity evolves around and between local attractors representing preferred mental states. Many physically-inspired models of…

Neurons and Cognition · Quantitative Biology 2016-09-06 Arian Ashourvan , Shi Gu , Marcelo G. Mattar , Jean M. Vettel , Danielle S. Bassett

Differential equation-based physiological models of sleep-wake networks describe sleep-wake regulation by simulating the activity of wake- and sleep-promoting neuronal populations and the modulation of these populations by homeostatic and…

Dynamical Systems · Mathematics 2021-11-16 Christina Athanasouli , Sofia H. Piltz , Cecilia Diniz Behn , Victoria Booth

The reflective homeostatic dynamics provides a minimal mechanism for self-organized criticality in neural systems. Starting from a reduced stochastic description, we demonstrate within the MSRJD field-theoretic framework that fluctuation…

Adaptation and Self-Organizing Systems · Physics 2026-01-13 Byung Gyu Chae