Related papers: Bypassing damaged nervous tissue
Objective: We confirm that alteration of a neuron structure can induce abnormalities in signal propagation for nervous systems, as observed in brain damage. Here, we investigate the effects of geometrical changes and damage of a neuron…
The synchronized activity of neuronal populations can lead to pathological over-synchronization in conditions such as epilepsy and Parkinson disease. Such states can be desynchronized by brief electrical pulses. But when the underlying…
Neurons primarily communicate through the emission of action potentials, or spikes. To generate a spike, a neuron's membrane potential must cross a defined threshold. Does this spiking mechanism inherently prevent neurons from transmitting…
Active cellular transport is a fundamental mechanism for protein and vesicle delivery, cell cycle and molecular degradation. Viruses can hijack the transport system and use it to reach the nucleus. Most transport processes consist of…
Under many physiological and pathological conditions such as division and migration, cells undergo dramatic deformations, under which their mechanical integrity is supported by cytoskeletal networks (i.e. intermediate filaments, F-actin,…
Neuroimaging is essential in brain studies for the diagnosis and identification of disease, structure, and function of the brain in its healthy and disease states. Literature shows that there are advantages of multitasking with some deep…
This paper attempts to review our studies on the propagation of signals in nerves over the past decade. The need for interdisciplinary studies is stressed that helps to understand the physical mechanisms of coupling the electrical,…
Effective metabolic waste clearance and maintaining ionic homeostasis are essential for the health and normal function of the central nervous system. To understand its mechanism and the role of fluid flow, we develop a multidomain…
It is well known that particles can get trapped by randomly placed obstacles when they are pushed too much. We present a model where the current in a disordered medium dies at a large external field, but is reborn when the activity is…
Multiple sclerosis is an inflammatory autoimmune demyelinating disease that is characterized by lesions in the central nervous system. Typically, magnetic resonance imaging (MRI) is used for tracking disease progression. Automatic image…
Bones are always wrapped by soft tissues. As a result, bones in their X-ray images are obscured and become unclear. In this paper, we tackle this problem and propose a novel task to virtually decompose the soft tissue and bone by image…
A new neural circuit is proposed by considering the myelin as an inductor. This new neural circuit can explain why the lump-parameter circuit used in previous C-P theory is valid. Meanwhile, it provides a new explanation of the biological…
Lesions in central nervous system (CNS) and their growth leads to debilitating diseases like Multiple Sclerosis (MS), Alzheimer's etc. We developed a model earlier which shows how the lesion growth can be arrested through a beneficial…
Health concerns associated with the advent of nanotechnologies have risen sharply when it was found that particles of nanoscopic dimensions reach the cell lumina. Plasma and organelle lipid membranes, which are exposed to both the incoming…
The assisted tunneling of a metastable state between barriers is investigated analytically by means of a simplified one dimensional model. A time dependent perturbation changes the pole spectrum of the wave function introducing a larger…
Magnetic nanoparticles (MNPs) are the foundation of several new strategies for neural repair and neurological therapies. The fact that a remote force can act on MNPs at the cytoplasmic space constitutes the essence of many new…
The Hodgkin-Huxley model of nerve pulse propagation relies on ion currents through specific resistors called ion channels. We discuss a number of classical thermodynamic findings on nerves that are not contained in this classical theory.…
What can cells gain by using disordered, rather than folded, proteins in the architecture of their skeleton? Disordered proteins take multiple co-existing conformations, and often contain segments which act as random-walk-shaped polymers.…
Replicating the computational functionalities and performances of the brain remains one of the biggest challenges for the future of information and communication technologies. Such an ambitious goal requires research efforts from the…
Loss of voluntary foot movement after spinal cord injury (SCI) can significantly limit independent mobility and quality of life. To improve motor output after injury, functional electrical stimulation (FES) is used to deliver stimulation…