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Grid cells in the entorhinal cortex, together with head direction, place, speed and border cells, are major contributors to the organization of spatial representations in the brain. In this work we introduce a novel theoretical and…

Neurons and Cognition · Quantitative Biology 2019-07-25 Fabio Anselmi , Micah M. Murray , Benedetta Franceschiello

Grid cells in the brain respond when an animal occupies a periodic lattice of "grid fields" during spatial navigation. The grid scale varies along the dorso-ventral axis of the entorhinal cortex. We propose that the grid system minimizes…

Neurons and Cognition · Quantitative Biology 2018-05-14 Xue-Xin Wei , Jason Prentice , Vijay Balasubramanian

Grid cells, discovered more than a decade ago [5], are neurons in the brain of mammals that fire when the animal is located near certain specific points in its familiar terrain. Intriguingly, these points form, for a single cell, a…

Neurons and Cognition · Quantitative Biology 2016-06-16 Christos H. Papadimitriou

The spatial responses of many of the cells recorded in all layers of rodent medial entorhinal cortex (mEC) show a triangular grid pattern, and once established might be based in part on path-integration mechanisms. Grid axes are tightly…

Neurons and Cognition · Quantitative Biology 2012-03-20 Bailu Si , Emilio Kropff , Alessandro Treves

Encoding the distance between locations in space is essential for accurate navigation. Grid cells, a functional class of neurons in medial entorhinal cortex, are believed to support this computation. However, existing theories of how…

Neurons and Cognition · Quantitative Biology 2025-11-12 Pritipriya Dasbehera , Akshunna S. Dogra , William T. Redman

Grid cells enable the brain to model the physical space of the world and navigate effectively via path integration, updating self-position using information from self-movement. Recent proposals suggest that the brain might use similar…

Artificial Intelligence · Computer Science 2021-02-19 Niels Leadholm , Marcus Lewis , Subutai Ahmad

Decades of research on the neural code underlying spatial navigation have revealed a diverse set of neural response properties. The Entorhinal Cortex (EC) of the mammalian brain contains a rich set of spatial correlates, including grid…

Neurons and Cognition · Quantitative Biology 2018-05-11 Christopher J. Cueva , Xue-Xin Wei

Place cells in the hippocampus are active when an animal visits a certain location (referred to as a place field) within an environment. Grid cells in the medial entorhinal cortex (MEC) respond at multiple locations, with firing fields that…

Neurons and Cognition · Quantitative Biology 2018-05-17 David M. Schwartz , O. Ozan Koyluoglu

Grid cells in the entorhinal cortex encode the position of an animal in its environment using spatially periodic tuning curves of varying periodicity. Recent experiments established that these cells are functionally organized in discrete…

Neurons and Cognition · Quantitative Biology 2016-01-13 Noga Weiss Mosheiff , Haggai Agmon , Avraham Moriel , Yoram Burak

For 20 years the beautiful structure in the grid cell code has presented an attractive puzzle: what computation do these representations subserve, and why does it manifest so curiously in neurons. The first question quickly attracted an…

Neurons and Cognition · Quantitative Biology 2026-03-06 William Dorrell , James C. R. Whittington

Grid cells in the entorhinal cortex are believed to establish their regular, spatially correlated firing patterns by path integration of the animal's motion. Mechanisms for path integration, e.g. in attractor network models, predict…

Neurons and Cognition · Quantitative Biology 2018-08-07 Eli Pollock , Niral Desai , Xue-Xin Wei , Vijay Balasubramanian

Grid cells are believed to play an important role in both spatial and non-spatial cognition tasks. A recent study observed the emergence of grid cells in an LSTM for path integration. The connection between biological and artificial neural…

Neurons and Cognition · Quantitative Biology 2020-09-10 Li Songlin , Deng Yangdong , Wang Zhihua

Work on deep learning-based models of grid cells suggests that grid cells generically and robustly arise from optimizing networks to path integrate, i.e., track one's spatial position by integrating self-velocity signals. In previous work,…

Neurons and Cognition · Quantitative Biology 2023-12-19 Rylan Schaeffer , Mikail Khona , Sanmi Koyejo , Ila Rani Fiete

The brain encodes spacial structure through a combinatorial code of neural activity. Experiments suggest such codes correspond to convex areas of the subject's environment. We present an intrinsic condition that implies a neural code may…

Combinatorics · Mathematics 2016-10-20 Robert Williams

Natural and artificial networks, from the cerebral cortex to large-scale power grids, face the challenge of converting noisy inputs into robust signals. The input fluctuations often exhibit complex yet statistically reproducible…

Adaptation and Self-Organizing Systems · Physics 2018-11-19 Henrik Ronellenfitsch , Jörn Dunkel , Michael Wilczek

The entorhinal-hippocampal formation is the mammalian brain's navigation system, encoding both physical and abstract spaces via grid cells. This system is well-studied in neuroscience, and its efficiency and versatility make it attractive…

Neural and Evolutionary Computing · Computer Science 2025-03-12 Sven Krausse , Emre Neftci , Friedrich T. Sommer , Alpha Renner

High-dimensional neural activity often reside in a low-dimensional subspace, referred to as neural manifolds. Grid cells in the medial entorhinal cortex provide a periodic spatial code that are organized near a toroidal manifold,…

Neurons and Cognition · Quantitative Biology 2025-10-22 Yuxing Jared Yao , Iris H. R. Yoon

We propose a sparse grids based adaptive noise reduction strategy for electrostatic particle-in-cell (PIC) simulations. Our approach is based on the key idea of relying on sparse grids instead of a regular grid in order to increase the…

About a decade ago grid cells were discovered in the medial entorhinal cortex of rat. Their peculiar firing patterns, which correlate with periodic locations in the environment, led to early hypothesis that grid cells may provide some form…

Neurons and Cognition · Quantitative Biology 2018-10-18 Jochen Kerdels , Gabriele Peters

Grid cells in the entorhinal cortex fire when animals that are exploring a certain region of space occupy the vertices of a triangular grid that spans the environment. Different neurons feature triangular grids that differ in their…

Neurons and Cognition · Quantitative Biology 2017-01-04 Alessandro Sanzeni , Vijay Balasubramanian , Guido Tiana , Massimo Vergassola
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