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Muscular dystrophy (MD) describes generalized progressive muscular weakness due to the wasting of muscle fibers. The progression of the disease is affected by known immunological and mechanical factors, and possibly other unknown…

Quantitative Methods · Quantitative Biology 2016-10-31 Amanda N. Cameron , Matthew T. Houston , Juan B. Gutierrez

We propose a statistical model of a large random network with high connectivity in order to describe the behavior of {\it E.\,coli} cells after exposure to acute stress. The building blocks of this network are feedback cycles typical of the…

Disordered Systems and Neural Networks · Physics 2022-02-22 S. Reich , S. Maoz , Y. Kaplan , H. Rappeport , N. Q. Balaban , O. Agam

Major Depressive Disorder is one of the leading causes of disability worldwide, yet its diagnosis still depends largely on subjective clinical assessments. Integrating Artificial Intelligence (AI) holds promise for developing objective,…

Artificial Intelligence · Computer Science 2026-05-01 Dorsa Macky Aleagha , Payam Zohari , Mostafa Haghir Chehreghani

Complex networks are ubiquitous: a cell, the human brain, a group of people and the Internet are all examples of interconnected many-body systems characterized by macroscopic properties that cannot be trivially deduced from those of their…

This paper (parts I and II) provides an expository introduction to monotone and near-monotone dynamical systems associated to biochemical networks, those whose graphs are consistent or near-consistent. Many conclusions can be drawn from…

Molecular Networks · Quantitative Biology 2007-05-23 Eduardo D. Sontag

Spatio-temporal network dynamics is an emergent property of many complex systems which remains poorly understood. We suggest a new approach to its study based on the analysis of dynamical motifs -- small subnetworks with periodic and…

Disordered Systems and Neural Networks · Physics 2007-05-23 Valentin P. Zhigulin

Deep neural networks give us a powerful method to model the training dataset's relationship between input and output. We can regard that as a complex adaptive system consisting of many artificial neurons that work as an adaptive memory as a…

Disordered Systems and Neural Networks · Physics 2024-05-08 Kenichi Nakazato

Major depressive disorder (MDD) is a heterogeneous condition; multiple underlying neurobiological substrates could be associated with treatment response variability. Understanding the sources of this variability and predicting outcomes has…

Dynamical networks are powerful tools for modeling a broad range of complex systems, including financial markets, brains, and ecosystems. They encode how the basic elements (nodes) of these systems interact altogether (via links) and evolve…

Physics and Society · Physics 2019-03-13 Edward Laurence , Nicolas Doyon , Louis J Dubé , Patrick Desrosiers

Individual and community psychology plays an important role in disaster management as human behavior exhibit diverse risk perceptions, recognition of the threats that exists, positive and negative emotions, panic, anger, rumor, stress and…

Physics and Society · Physics 2023-01-19 Liaquat Hossain

Depression is the most common psychological disorder and is considered as a leading cause of disability and suicide worldwide. An automated system capable of detecting signs of depression in human speech can contribute to ensuring timely…

Sound · Computer Science 2023-02-21 Mashrura Tasnim , Jekaterina Novikova

Major depressive disorder (MDD) is a debilitating health condition affecting a substantial part of the world's population. At present, there is no biological theory of MDD, and treatment is partial at best. Here I present a theory of MDD…

Neurons and Cognition · Quantitative Biology 2024-08-14 Ari Rappoport

In spite of a few attempts in understanding the dynamical robustness of complex networks, this extremely important subject of research is still in its dawn as compared to the other dynamical processes on networks. We hereby consider the…

Adaptation and Self-Organizing Systems · Physics 2022-03-24 Soumen Majhi

Muscular Dystrophy is a group of genetic disorders that progressively affect the strength and functioning of muscles, thereby affecting millions of people worldwide. The lifetime nature of MD requires continuous follow-up care due to its…

Machine Learning · Computer Science 2024-11-26 Mohammed Akkaoui

Due to the complexity of the human body, most diseases present a high inter-personal variability in the way they manifest, i.e. in their phenotype, which has important clinical repercussions - as for instance the difficulty in defining…

Physics and Society · Physics 2018-06-06 Massimiliano Zanin , Juan Manuel Tuñas , Ernestina Menasalvas

Major depressive disorder (MDD) is a complex psychiatric disorder that affects the lives of hundreds of millions of individuals around the globe. Even today, researchers debate if morphological alterations in the brain are linked to MDD,…

Quantitative Methods · Quantitative Biology 2025-01-27 Roberto Goya-Maldonado , Tracy Erwin-Grabner , Ling-Li Zeng , Christopher R. K. Ching , Andre Aleman , Alyssa R. Amod , Zeynep Basgoze , Francesco Benedetti , Bianca Besteher , Katharina Brosch , Robin Bülow , Romain Colle , Colm G. Connolly , Emmanuelle Corruble , Baptiste Couvy-Duchesne , Kathryn Cullen , Udo Dannlowski , Christopher G. Davey , Annemiek Dols , Jan Ernsting , Jennifer W. Evans , Lukas Fisch , Paola Fuentes-Claramonte , Ali Saffet Gonul , Ian H. Gotlib , Hans J. Grabe , Nynke A. Groenewold , Dominik Grotegerd , Tim Hahn , J. Paul Hamilton , Laura K. M. Han , Ben J. Harrison , Tiffany C. Ho , Neda Jahanshad , Alec J. Jamieson , Andriana Karuk , Tilo Kircher , Bonnie Klimes-Dougan , Sheri-Michelle Koopowitz , Thomas Lancaster , Ramona Leenings , Meng Li , David E. J. Linden , Frank P. MacMaster , David M. A. Mehler , Susanne Meinert , Elisa Melloni , Bryon A. Mueller , Benson Mwangi , Igor Nenadić , Amar Ojha , Yasumasa Okamoto , Mardien L. Oudega , Brenda W. J. H. Penninx , Sara Poletti , Edith Pomarol-Clotet , Maria J. Portella , Elena Pozzi , Joaquim Radua , Elena Rodríguez-Cano , Matthew D. Sacchet , Raymond Salvador , Anouk Schrantee , Kang Sim , Jair C. Soares , Aleix Solanes , Dan J. Stein , Frederike Stein , Aleks Stolicyn , Sophia I. Thomopoulos , Yara J. Toenders , Aslihan Uyar-Demir , Eduard Vieta , Yolanda Vives-Gilabert , Henry Völzke , Martin Walter , Heather C. Whalley , Sarah Whittle , Nils Winter , Katharina Wittfeld , Margaret J. Wright , Mon-Ju Wu , Tony T. Yang , Carlos Zarate , Dick J. Veltman , Lianne Schmaal , Paul M. Thompson

Musculoskeletal disorder (MSD) is one of the major health problems in physical work especially in manual handling jobs. In several literatures, muscle fatigue is considered to be closely related to MSD, especially for muscle related…

Robotics · Computer Science 2022-01-05 Liang Ma , Damien Chablat , Fouad Bennis , Wei Zhang

Psychiatric disorders have been traditionally conceptualized as latent conditions producing observable symptoms, but recent studies suggest that psychopathology may emerge from symptoms interactions. Psychometric networking model these…

Social and Information Networks · Computer Science 2026-04-27 Francesca Possenti , Laura Girelli , Paolo Tieri , Manuela Petti

The relation between network structure and dynamics is determinant for the behavior of complex systems in numerous domains. An important long-standing problem concerns the properties of the networks that optimize the dynamics with respect…

Adaptation and Self-Organizing Systems · Physics 2017-12-07 Takashi Nishikawa , Jie Sun , Adilson E. Motter

Social isolation (SI) in older adults has emerged as a critical mental health concern, with established links to cognitive decline. While depression is hypothesized to mediate this relationship, the longitudinal mechanisms remain unclear.…

Applications · Statistics 2025-06-19 Yingchen Liu , Haixin Jiang