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Biological and physical systems often exhibit distinct structures at different spatial/temporal scales. Persistent homology is an algebraic tool that provides a mathematical framework for analyzing the multi-scale structures frequently…

Algebraic Topology · Mathematics 2016-02-01 Jonathan Jaquette , Miroslav Kramár

Persistent homology is a tool that can be employed to summarize the shape of data by quantifying homological features. When the data is an object in $\mathbb{R}^d$, the (augmented) persistent homology transform ((A)PHT) is a family of…

Computational Geometry · Computer Science 2022-12-27 Brittany Terese Fasy , Samuel Micka , David L. Millman , Anna Schenfisch , Lucia Williams

Artificial intelligence-assisted drug design is revolutionizing the pharmaceutical industry. Effective molecular features are crucial for accurate machine learning predictions, and advanced mathematics plays a key role in designing these…

Biomolecules · Quantitative Biology 2024-08-27 Hongsong Feng , Li Shen , Jian Liu , Guo-Wei Wei

Persistent homology is one of the most active branches of Computational Algebraic Topology with applications in several contexts such as optical character recognition or analysis of point cloud data. In this paper, we report on the formal…

Logic in Computer Science · Computer Science 2012-09-11 Jónathan Heras , Thierry Coquand , Anders Mörtberg , Vincent Siles

We present a novel method to explicitly incorporate topological prior knowledge into deep learning based segmentation, which is, to our knowledge, the first work to do so. Our method uses the concept of persistent homology, a tool from…

Computer Vision and Pattern Recognition · Computer Science 2019-01-30 James R. Clough , Ilkay Oksuz , Nicholas Byrne , Julia A. Schnabel , Andrew P. King

The color of skin lesions is an important diagnostic feature for identifying malignant melanoma and other skin diseases. Typical colors associated with melanocytic lesions include tan, brown, black, red, white, and blue gray. This study…

Quantitative Methods · Quantitative Biology 2026-01-30 M. A. Rasel , Sameem Abdul Kareem , Unaizah Obaidellah

Topological data analysis uses tools from topology -- the mathematical area that studies shapes -- to create representations of data. In particular, in persistent homology, one studies one-parameter families of spaces associated with data,…

Machine Learning · Computer Science 2020-12-01 Guido Montúfar , Nina Otter , Yuguang Wang

0-dimensional persistent homology is known, from a computational point of view, as the easy case. Indeed, given a list of $n$ edges in non-decreasing order of filtration value, one only needs a union-find data structure to keep track of the…

Computational Geometry · Computer Science 2023-12-12 Marc Glisse

Persistent homology is a method for probing topological properties of point clouds and functions. The method involves tracking the birth and death of topological features (2000) as one varies a tuning parameter. Features with short…

Persistent homology is a cornerstone of topological data analysis, offering a multiscale summary of topology with robustness to nuisance transformations, such as rotations and small deformations. Persistent homology has seen broad use…

Methodology · Statistics 2025-11-19 Zitian Wu , Arkaprava Roy , Leo L. Duan

Persistence diagrams are important tools in the field of topological data analysis that describe the presence and magnitude of features in a filtered topological space. However, current approaches for comparing a persistence diagram to a…

Computational Geometry · Computer Science 2021-03-24 Brittany Terese Fasy , Xiaozhou He , Zhihui Liu , Samuel Micka , David L. Millman , Binhai Zhu

Persistent homology is a technique recently developed in algebraic and computational topology well-suited to analysing structure in complex, high-dimensional data. In this paper, we exposit the theory of persistent homology from first…

Applications · Statistics 2016-11-30 Matthew Pietrosanu

Melanoma is the most deadly form of skin cancer. Tracking the evolution of nevi and detecting new lesions across the body is essential for the early detection of melanoma. Despite prior work on longitudinal tracking of skin lesions in 3D…

Computer Vision and Pattern Recognition · Computer Science 2024-12-25 Wei-Lun Huang , Minghao Xue , Zhiyou Liu , Davood Tashayyod , Jun Kang , Amir Gandjbakhche , Misha Kazhdan , Mehran Armand

Persistence diagrams, combining geometry and topology for an effective shape description used in pattern recognition, have already proven to be an effective tool for shape representation with respect to a certainfiltering function.…

Algebraic Topology · Mathematics 2018-12-26 Alessia Angeli , Massimo Ferri , Ivan Tomba

Information networks are becoming increasingly popular to capture complex relationships across various disciplines, such as social networks, citation networks, and biological networks. The primary challenge in this domain is measuring…

Algebraic Topology · Mathematics 2019-07-23 Mehmet Emin Aktas , Esra Akbas , Ahmed El Fatmaoui

Classical persistent homology is a powerful mathematical tool for shape comparison. Unfortunately, it is not tailored to study the action of transformation groups that are different from the group Homeo(X) of all self-homeomorphisms of a…

Algebraic Topology · Mathematics 2013-12-24 Patrizio Frosini

Persistent homology (PH) is a recently developed theory in the field of algebraic topology to study shapes of datasets. It is an effective data analysis tool that is robust to noise and has been widely applied. We demonstrate a general…

Signal Processing · Electrical Eng. & Systems 2020-05-05 Yu-Min Chung , Chuan-Shen Hu , Yu-Lun Lo , Hau-Tieng Wu

Persistent Homology (PH) has been successfully used to train networks to detect curvilinear structures and to improve the topological quality of their results. However, existing methods are very global and ignore the location of topological…

Computer Vision and Pattern Recognition · Computer Science 2022-12-27 Doruk Oner , Adélie Garin , Mateusz Koziński , Kathryn Hess , Pascal Fua

Existing studies for automated melanoma diagnosis are based on single-time point images of lesions. However, melanocytic lesions de facto are progressively evolving and, moreover, benign lesions can progress into malignant melanoma.…

Computer Vision and Pattern Recognition · Computer Science 2020-06-22 Zhen Yu , Jennifer Nguyen , Xiaojun Chang , John Kelly , Catriona Mclean , Lei Zhang , Victoria Mar , Zongyuan Ge

In machine-learning-assisted high-throughput defect studies, a defect-aware latent representation of the supercell structure is crucial to the accurate prediction of defect properties. The performance of current graph neural network (GNN)…

Materials Science · Physics 2024-11-01 Zhenyao Fang , Qimin Yan