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Innovative methodologies for reliably and inexpensively sequencing DNA can lead to a new era of personalized medicine. In this work, we performed a theoretical investigation of a nanogap-based all electronic DNA sequencing device. To do so,…

We present an approach to approximating static properties of glasses without experimental inputs rooted in the first-principles random structure sampling. In our approach, the glassy system is represented by a collection (composite) of…

Materials Science · Physics 2025-10-02 Laszlo Wolf , Andrew Novick , Vladan Stevanović

We have micromachined a silicon-chip device that transports DNA with a Brownian ratchet that rectifies the Brownian motion of microscopic particles. Transport properties for a DNA 50mer agree with theoretical predictions, and the DNA…

Recent experiments of translocation of double stranded DNA through nanopores [M. Wanunu \textit{et al.} Nature Nanotech. {\bf 5}, 160 (2010)] reveal that the DNA capture rate can be significantly influenced by a salt gradient across the…

Soft Condensed Matter · Physics 2015-03-17 Marius M. Hatlo , Debabrata Panja , René van Roij

The experimental conditions by which electromagnetic signals (EMS) of low frequency can be emitted by diluted aqueous solutions of some bacterial and viral DNAs are described. That the recorded EMS and nanostructures induced in water carry…

Short blunt-ended DNA duplexes comprising 6 to 20 base pairs self-assemble into polydisperse semi-flexible chains due to hydrophobic stacking interactions between terminal base pairs. Above a critical concentration, which depends on…

Soft Condensed Matter · Physics 2012-07-17 Cristiano De Michele , Lorenzo Rovigatti , Tommaso Bellini , Francesco Sciortino

A theory is presented of DNA hairpins enclosed in a nanochannel. A hairpin becomes constrained as it approaches the wall of a channel which leads to an entropic force causing the hairpin to tighten. The free energy of the hairpin computed…

Soft Condensed Matter · Physics 2009-11-11 Theo Odijk

Author suggests and analyzes new universal trapping method of comparatively slow-speed particles of a rarefied gas medium in the potential well induced by the nonhomogeneous electromagnetic field increasing with time (up to some moment).…

General Physics · Physics 2014-01-14 Azad Ch. Izmailov

In this letter, we characterize experimentally the diffusiophoretic motion of colloids and lambda- DNA toward higher concentration of solutes, using microfluidic technology to build spatially- and temporally-controlled concentration…

Soft Condensed Matter · Physics 2010-04-09 J. Palacci , B. Abecassis , C. Cottin-Bizonne , C. Ybert , L. Bocquet

We describe an atom trapping mechanism based upon differential optical pumping between metastable hyperfine states by partially-displaced laser beams in the absence of a magnetic field. With realistic laser powers, trap spring constants…

Atomic Physics · Physics 2015-06-15 Nathan Cooper , Tim Freegarde

We suggest that it might be possible to trap the electron in a cavity of a macrocycle molecule, in the same way this trapping occurs cooperatively, by several solvent molecules, in hydroxylic liquids. Such an encapsulated electron is a…

Chemical Physics · Physics 2015-06-26 Ilya A. Shkrob , John A. Schlueter

We describe an approach to optically trapping small, chemically stable molecules at cryogenic temperatures by buffer-gas loading a deep optical dipole trap. The ~10 K trap depth will be produced by a tightly-focused, 1064-nm cavity capable…

Quartz nanopipettes are an important emerging class of electric single-molecule sensors for DNA, proteins, their complexes as well as other biomolecular targets. However, in comparison to other resistive pulse sensors, nanopipettes…

Mesoscale and Nanoscale Physics · Physics 2025-03-18 Rand A. Al-Waqfi , Cengiz Khan , Oliver J. Irving , Lauren Matthews , Tim Albrecht

Optical trapping has proven to be a valuable experimental technique for precisely controlling small dielectric objects. However, due to their very nature, conventional optical traps are diffraction limited and require high intensities to…

The behavior of long DNA molecules in a cell-sized confined space was investigated. We prepared water-in-oil droplets covered by phospholipids, which mimic the inner space of a cell, following the encapsulation of DNA molecules with…

Biological Physics · Physics 2015-04-14 T. Hamada , R. Fujimoto , S. F. Shimobayashi , M. Ichikawa , M. Takagi

Since the advent of atom laser-cooling, trapping or cooling natural molecules has been a long standing and challenging goal. Here, we demonstrate a method for laser-trapping molecules that is radically novel in its configuration, in its…

Optics · Physics 2015-06-04 M. Alharbi , A. Husakou , B. Debord , F. Gerome , F. Benabid

Passive and effective fluid capture and transport at small scale is crucial for industrial and medical applications, especially for the realisation of point-of-care tests. Performing these tests involves several steps including biological…

Fluid Dynamics · Physics 2024-10-15 Emmanuel Siéfert , Benoit Scheid , Fabian Brau , Jean Cappello

Nanometre-scale pores and capillaries have long been studied because of their importance in many natural phenomena and their use in numerous applications. A more recent development is the ability to fabricate artificial capillaries with…

Experiments have revealed correlation-driven behavior of DNA in charged solutions, including charge inversion and condensation. This paper presents calculations of a lattice-gas model of charge inversion for the adsorption of charged dimers…

Soft Condensed Matter · Physics 2019-02-15 Matthew D. Sievert , Marilyn F. Bishop , Tom McMullen

The short supercoiled circular DNA molecules are shown to be glassy systems and canonical Metropolis Monte Carlo simulations of the systems tend to get stuck in local metastable energy basins. A novel Monte Carlo algorithm is developed to…

Soft Condensed Matter · Physics 2016-08-31 Zhang Yang
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