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Biological systems are driven by intricate interactions among the complex array of molecules that comprise the cell. Many methods have been developed to reconstruct network models of those interactions. These methods often draw on large…

Molecular Networks · Quantitative Biology 2018-06-29 Marieke Lydia Kuijjer , Matthew Tung , GuoCheng Yuan , John Quackenbush , Kimberly Glass

Simultaneous feature selection and non-linear function estimation is challenging in modeling, especially in high-dimensional settings where the number of variables exceeds the available sample size. In this article, we investigate the…

Machine Learning · Statistics 2026-01-05 Bin Luo , Susan Halabi

We consider a problem of estimating a sparse group of sparse normal mean vectors. The proposed approach is based on penalized likelihood estimation with complexity penalties on the number of nonzero mean vectors and the numbers of their…

Statistics Theory · Mathematics 2012-03-02 Felix Abramovich , Vadim Grinshtein

Finite Gaussian mixture models are widely used for model-based clustering of continuous data. Nevertheless, since the number of model parameters scales quadratically with the number of variables, these models can be easily…

Methodology · Statistics 2018-09-25 Michael Fop , Thomas Brendan Murphy , Luca Scrucca

In this paper, we first reviewed several biclustering methods that are used to identify the most significant clusters in gene expression data. Here we mainly focused on the SSVD(sparse SVD) method and tried a new sparse penalty named…

Machine Learning · Statistics 2023-09-01 Jiqiang Wang

Genetic variants identified to date by genome-wide association studies only explain a small fraction of total heritability. Gene-by-gene interaction is one important potential source of unexplained heritability. In the first part of this…

Methodology · Statistics 2016-05-10 Chen Lu

Variable selection methods are required in practical statistical modeling, to identify and include only the most relevant predictors, and then improving model interpretability. Such variable selection methods are typically employed in…

We consider the problem of sparse channel estimation in massive multiple-input multiple-output systems. In this context, we propose an enhanced version of the sparse Bayesian learning (SBL) framework, referred to as enhanced SBL (E-SBL),…

Signal Processing · Electrical Eng. & Systems 2025-01-15 Arttu Arjas , Italo Atzeni

Deep Belief Networks (DBN) have been successfully applied on popular machine learning tasks. Specifically, when applied on hand-written digit recognition, DBNs have achieved approximate accuracy rates of 98.8%. In an effort to optimize the…

Neural and Evolutionary Computing · Computer Science 2013-02-25 Xanadu Halkias , Sebastien Paris , Herve Glotin

In this paper we consider high-dimensional multiclass classification by sparse multinomial logistic regression. We propose first a feature selection procedure based on penalized maximum likelihood with a complexity penalty on the model size…

Statistics Theory · Mathematics 2020-11-20 Felix Abramovich , Vadim Grinshtein , Tomer Levy

Sparse neural networks attract increasing interest as they exhibit comparable performance to their dense counterparts while being computationally efficient. Pruning the dense neural networks is among the most widely used methods to obtain a…

Neural and Evolutionary Computing · Computer Science 2022-11-11 Zahra Atashgahi , Joost Pieterse , Shiwei Liu , Decebal Constantin Mocanu , Raymond Veldhuis , Mykola Pechenizkiy

Discriminating between correct and incorrect substrates is a core process in biology but how is energy apportioned between the conflicting demands of accuracy ($\mu$), speed ($\sigma$) and total entropy production rate ($P$)? Previous…

Molecular Networks · Quantitative Biology 2019-06-18 Felix Wong , Ariel Amir , Jeremy Gunawardena

A method of simultaneously optimizing both the structure of neural networks and the connection weights in a single training loop can reduce the enormous computational cost of neural architecture search. We focus on the probabilistic…

Neural and Evolutionary Computing · Computer Science 2022-05-27 Shota Saito , Shinichi Shirakawa

This paper proposes a sparse Bayesian treatment of deep neural networks (DNNs) for system identification. Although DNNs show impressive approximation ability in various fields, several challenges still exist for system identification…

Systems and Control · Electrical Eng. & Systems 2022-06-02 Hongpeng Zhou , Chahine Ibrahim , Wei Xing Zheng , Wei Pan

Artificial Neural Networks (ANNs) have emerged as hot topics in the research community. Despite the success of ANNs, it is challenging to train and deploy modern ANNs on commodity hardware due to the ever-increasing model size and the…

Neural and Evolutionary Computing · Computer Science 2021-01-19 Shiwei Liu , Decebal Constantin Mocanu , Amarsagar Reddy Ramapuram Matavalam , Yulong Pei , Mykola Pechenizkiy

In many organisms the expression levels of each gene are controlled by the activation levels of known "Transcription Factors" (TF). A problem of considerable interest is that of estimating the "Transcription Regulation Networks" (TRN)…

Applications · Statistics 2010-11-09 Gareth M. James , Chiara Sabatti , Nengfeng Zhou , Ji Zhu

Modeling the associations between real world entities from their multivariate cross-sectional profiles can provide cues into the concerted working of these entities as a system. Several techniques have been proposed for deciphering these…

Machine Learning · Computer Science 2025-01-07 Radha Nagarajan , Marco Scutari

The problem of multiple kernel learning based on penalized empirical risk minimization is discussed. The complexity penalty is determined jointly by the empirical $L_2$ norms and the reproducing kernel Hilbert space (RKHS) norms induced by…

Statistics Theory · Mathematics 2012-11-14 Vladimir Koltchinskii , Ming Yuan

We propose an sparse Bayesian learning (SBL)-based method that leverages group sparsity and multiple parameterized dictionaries to detect the relevant dictionary entries and estimate their continuous parameters by combining data from…

Signal Processing · Electrical Eng. & Systems 2025-11-05 Jakob Möderl , Anders Malte Westerkam , Alexander Venus , Erik Leitinger

Variational inference has been widely used in machine learning literature to fit various Bayesian models. In network analysis, this method has been successfully applied to solve the community detection problems. Although these results are…

Machine Learning · Statistics 2024-05-22 Xuezhen Li , Can M. Le