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In precision medicine, Dynamic Treatment Regimes (DTRs) are treatment protocols that adapt over time in response to a patient's observed characteristics. A DTR is a set of decision functions that takes an individual patient's information as…

Methodology · Statistics 2022-03-17 Cong Jiang , Michael Wallace , Mary Thompson

We present a virtual reality (VR) experience that creates a research-grade benchmark in assessing patients with active upper-limb tremor, while simultaneously offering the opportunity for patients to engage with VR experiences without their…

In exploring the simulation of human rhythmic perception and synchronization capabilities, this study introduces a computational model inspired by the physical and biological processes underlying rhythm processing. Utilizing a reservoir…

Neurons and Cognition · Quantitative Biology 2025-03-28 Zhongju Yuan , Wannes Van Ransbeeck , Geraint Wiggins , Dick Botteldooren

Objective: Evaluate a method for the estimation of the nocturnal systolic blood pressure (SBP) dip from 24-hour blood pressure trends using a wrist-worn photoplethysmography (PPG) sensor and a deep neural network in free-living individuals,…

Rehabilitation training is the primary intervention to improve motor recovery after stroke, but a tool to measure functional training does not currently exist. To bridge this gap, we previously developed an approach to classify functional…

Machine Learning · Computer Science 2021-12-24 Avinash Parnandi , Jasim Uddin , Dawn M. Nilsen , Heidi Schambra

Large clinical evidence acknowledges the crucial role played by physical activity in delaying the progression of type-2 diabetes. However, the literature lacks control approaches that leverage exercise for type-2 diabetes control and more…

Systems and Control · Electrical Eng. & Systems 2025-01-23 Pierluigi Francesco De Paola , Alessandro Borri , Fabrizio Dabbene , Pasquale Palumbo , Alessia Paglialonga

Small continuous sensory and mechanical perturbations have often been used to identify properties of the closed-loop neural control of posture and other systems that are approximately linear time invariant. Here we extend this approach to…

Neurons and Cognition · Quantitative Biology 2016-10-31 Tim Kiemel , David Logan , John J. Jeka

Contraction metrics are crucial in control theory because they provide a powerful framework for analyzing stability, robustness, and convergence of various dynamical systems. However, identifying these metrics for complex nonlinear systems…

Optimization and Control · Mathematics 2025-04-25 Haoyu Li , Xiangru Zhong , Bin Hu , Huan Zhang

Parkinson's disease (PD) belongs to the class of neurodegenerative disorders that affect the central nervous system. It is usually defined as the gradual loss of dopaminergic neurons in the substantia nigra pars compacta, which causes both…

Neurons and Cognition · Quantitative Biology 2024-11-01 Hina Shaheen , Roderick Melnik

This work explores the problem of exercise quality measurement since it is essential for effective management of diseases like cerebral palsy (CP). This work examines the assessment of quality of large amplitude movement (LAM) exercises…

Computer Vision and Pattern Recognition · Computer Science 2016-09-01 Paritosh Parmar , Brendan Tran Morris

We here present work a generalized low-level technical framework aimed to provide musical biofeedback in post-stroke balance and gait rehabilitation, built by an iterative user-centered process. The framework comprises wireless wearable…

Human-Computer Interaction · Computer Science 2020-12-02 Prithvi Kantan , Erika G. Spaich , Sofia Dahl

The ability to modulate brain states using targeted stimulation is increasingly being employed to treat neurological disorders and to enhance human performance. Despite the growing interest in brain stimulation as a form of neuromodulation,…

Neurons and Cognition · Quantitative Biology 2016-01-07 Sarah Feldt Muldoon , Fabio Pasqualetti , Shi Gu , Matthew Cieslak , Scott T. Grafton , Jean M. Vettel , Danielle S. Bassett

Epileptic seizures arise from abnormally synchronised neural activity and remain a major global health challenge, affecting more than 50 million people worldwide. Despite advances in pharmacological interventions, a significant proportion…

Signal Processing · Electrical Eng. & Systems 2025-12-19 Arfan Ghani

In this paper, we restructure the Neural Interconnection and Damping Assignment - Passivity Based Control (Neural IDA-PBC) design methodology, and we formally analyze its closed-loop properties. Neural IDA-PBC redefines the IDA-PBC design…

Systems and Control · Electrical Eng. & Systems 2024-09-25 Santiago Sanchez-Escalonilla , Samuele Zoboli , Bayu Jayawardhana

Despite the fact that only a small portion of muscles are affected in motion disease and disorders, medical therapies do not distinguish between healthy and unhealthy muscles. In this paper, a method is devised in order to calculate the…

Artificial Intelligence · Computer Science 2024-03-06 Sina Saadati , Mohammadreza Razzazi

Effective stroke recovery requires continuous rehabilitation integrated with daily living. To support this need, we propose a home-based rehabilitation exercise and feedback system. The system consists of (1) hardware setup with RGB-D…

Image and Video Processing · Electrical Eng. & Systems 2026-02-03 Suhyeon Lim , Ye-eun Kim , Andrew J. Choi

In this work, we introduce a novel gradient descent-based approach for optimizing control systems, leveraging a new representation of stable closed-loop dynamics as a function of two matrices i.e. the step size or direction matrix and value…

Optimization and Control · Mathematics 2024-09-18 Ramin Esmzad , Hamidreza Modares

A key ingredient to achieving intelligent behavior is physical understanding that equips robots with the ability to reason about the effects of their actions in a dynamic environment. Several methods have been proposed to learn dynamics…

Robotics · Computer Science 2020-01-24 David Millard , Eric Heiden , Shubham Agrawal , Gaurav S. Sukhatme

Stroke is known as a major global health problem, and for stroke survivors it is key to monitor the recovery levels. However, traditional stroke rehabilitation assessment methods (such as the popular clinical assessment) can be subjective…

Signal Processing · Electrical Eng. & Systems 2022-12-27 Xi Chen , Yu Guan , Jian Qing Shi , Xiu-Li Du , Janet Eyre

Parkinson's disease (PD) is a progressive neurodegenerative disorder that results in a variety of motor dysfunction symptoms, including tremors, bradykinesia, rigidity and postural instability. The diagnosis of PD mainly relies on clinical…

Computer Vision and Pattern Recognition · Computer Science 2022-07-15 Haozheng Zhang , Edmond S. L. Ho , Xiatian Zhang , Hubert P. H. Shum