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There has been an increasing interest in using neural networks in closed-loop control systems to improve performance and reduce computational costs for on-line implementation. However, providing safety and stability guarantees for these…

Systems and Control · Electrical Eng. & Systems 2020-04-20 Haimin Hu , Mahyar Fazlyab , Manfred Morari , George J. Pappas

Despite their success in massive engineering applications, deep neural networks are vulnerable to various perturbations due to their black-box nature. Recent study has shown that a deep neural network can misclassify the data even if the…

Machine Learning · Computer Science 2021-04-29 Zhuotong Chen , Qianxiao Li , Zheng Zhang

A central challenge in sensory neuroscience is describing how the activity of populations of neurons can represent useful features of the external environment. However, while neurophysiologists have long been able to record the responses of…

Neural and Evolutionary Computing · Computer Science 2015-02-18 Chuan-Yung Tsai , David D. Cox

Objective - This work introduces Dareplane, a modular and broad technology-agnostic open source software platform for brain-computer interface research with an application focus on adaptive deep brain stimulation (aDBS). One difficulty for…

Other Quantitative Biology · Quantitative Biology 2025-02-19 Matthias Dold , Joana Pereira , Bastian Sajonz , Volker A. Coenen , Jordy Thielen , Marcus L. F. Janssen , Michael Tangermann

Recent advances in neurotechnologies and decades of scientific and clinical research have made closed-loop electrical neuromodulation one of the most promising avenues for the treatment of drug-resistant epilepsy (DRE), a condition that…

Systems and Control · Electrical Eng. & Systems 2026-03-30 Gagan Acharya , Erfan Nozari

Stroke patients have symptoms of cerebral functional disturbance that could aggressively impair patient's physical mobility, such as freezing of hand movements. Although rehabilitation training from external devices is beneficial for hand…

Signal Processing · Electrical Eng. & Systems 2020-06-30 Xiaotong Gu , Zehong Cao

Deep Brain Stimulation (DBS) has gained increasing attention as an effective method to mitigate Parkinsons disease (PD) disorders. Existing DBS systems are open-loop such that the system parameters are not adjusted automatically based on…

Computer Vision and Pattern Recognition · Computer Science 2016-11-18 Hosein M. Golshan , Adam O. Hebb , Sara J. Hanrahan , Joshua Nedrud , Mohammad H. Mahoor

Spinal cord stimulation (SCS) is a therapeutic approach used for the management of chronic pain. It involves the delivery of electrical impulses to the spinal cord via an implanted device, which when given suitable stimulus parameters can…

Transcranial Electrical Stimulation (TCES) and Deep Brain Stimulation (DBS) are two different applications of electrical current to the brain used in different areas of medicine. Both have a similar frequency dependence of their efficiency,…

Neurons and Cognition · Quantitative Biology 2019-07-15 Markus Schütt , Jens Christian Claussen

Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide and affects around 1% of the (60+ years old) elderly population in industrial nations. More than 80% of PD patients suffer from motor symptoms, which…

We propose a novel dual-loop system that synergistically combines responsive neurostimulation (RNS) implants with artificial intelligence-driven wearable devices for treating post-traumatic stress disorder (PTSD) and enabling naturalistic…

Neurons and Cognition · Quantitative Biology 2025-03-25 Edward Hong Wang , Cynthia Xin Wen

Cluster synchronization underlies various functions in the brain. Abnormal patterns of cluster synchronization are often associated with neurological disorders. Deep brain stimulation (DBS) is a neurosurgical technique used to treat several…

Systems and Control · Electrical Eng. & Systems 2022-04-06 Yuzhen Qin , Danielle S. Bassett , Fabio Pasqualetti

Neural networks modularity is a major challenge for the development of control circuits of neural activity. Under physiological limitations, the accessible regions for external stimulation are possibly different from the functionally…

Neurons and Cognition · Quantitative Biology 2018-02-23 Hanna Keren , Johannes Partzsch , Shimon Marom , Christian Mayr

Neural Networks (NNs) can provide major empirical performance improvements for closed-loop systems, but they also introduce challenges in formally analyzing those systems' safety properties. In particular, this work focuses on estimating…

Systems and Control · Electrical Eng. & Systems 2022-02-03 Michael Everett , Golnaz Habibi , Chuangchuang Sun , Jonathan P. How

Neural Networks (NNs) can provide major empirical performance improvements for robotic systems, but they also introduce challenges in formally analyzing those systems' safety properties. In particular, this work focuses on estimating the…

Systems and Control · Electrical Eng. & Systems 2021-05-26 Michael Everett , Golnaz Habibi , Jonathan P. How

Models of the cortico-basal ganglia network and volume conductor models of the brain can provide insight into the mechanisms of action of deep brain stimulation (DBS). In this study, the coupling of a network model, under parkinsonian…

Neurons and Cognition · Quantitative Biology 2017-05-31 Christian Schmidt , Eleanor Dunn , Madeleine Lowery , Ursula van Rienen

Conventional deep brain stimulation (DBS) of basal ganglia uses high-frequency regular electrical pulses to treat Parkinsonian motor symptoms and has a series of limitations. Relatively new and not yet clinically tested optogenetic…

Neurons and Cognition · Quantitative Biology 2021-04-26 Shivakeshavan Ratnadurai-Giridharan , Chung Cheung , Leonid Rubchinsky

This paper proposes a new framework and several results to quantify the performance of data-driven state-feedback controllers for linear systems against targeted perturbations of the training data. We focus on the case where subsets of the…

Systems and Control · Electrical Eng. & Systems 2019-12-24 Rajasekhar Anguluri , Abed AlRahman Al Makdah , Vaibhav Katewa , Fabio Pasqualetti

Research on transcranial magnetic stimulation (TMS) combined with encephalography feedback (EEG-TMS) has shown that the phase of the sensorimotor mu rhythm is predictive of corticospinal excitability. Thus, if the subject-specific optimal…

Neurons and Cognition · Quantitative Biology 2024-10-10 Miriam Kirchhoff , Dania Humaidan , Ulf Ziemann

Deep Neural Networks(DNN) have excessively advanced the field of computer vision by achieving state of the art performance in various vision tasks. These results are not limited to the field of vision but can also be seen in speech…

Cryptography and Security · Computer Science 2018-06-07 Chirag Agarwal , Bo Dong , Dan Schonfeld , Anthony Hoogs
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