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Genetic algorithms, computer programs that simulate natural evolution, are increasingly applied across many disciplines. They have been used to solve various optimisation problems from neural network architecture search to strategic games,…

Neural and Evolutionary Computing · Computer Science 2021-09-14 Aymeric Vie , Alissa M. Kleinnijenhuis , Doyne J. Farmer

Convolutional neural networks (CNNs) are effective at solving difficult problems like visual recognition, speech recognition and natural language processing. However, performance gain comes at the cost of laborious trial-and-error in…

Neural and Evolutionary Computing · Computer Science 2018-12-20 Yiheng Zhu , Yichen Yao , Zili Wu , Yujie Chen , Guozheng Li , Haoyuan Hu , Yinghui Xu

Bayesian Networks (BNs) have become increasingly popular over the last few decades as a tool for reasoning under uncertainty in fields as diverse as medicine, biology, epidemiology, economics and the social sciences. This is especially true…

Machine Learning · Computer Science 2022-10-27 Neville K. Kitson , Anthony C. Constantinou , Zhigao Guo , Yang Liu , Kiattikun Chobtham

Recent progress in Generative Adversarial Networks (GANs) has shown promising signs of improving GAN training via architectural change. Despite some early success, at present the design of GAN architectures requires human expertise,…

Machine Learning · Computer Science 2019-06-27 Hanchao Wang , Jun Huan

With different genomes available, unsupervised learning algorithms are essential in learning genome-wide biological insights. Especially, the functional characterization of different genomes is essential for us to understand lives. In this…

Genomics · Quantitative Biology 2015-08-04 Ka-Chun Wong , Yue Li , Zhaolei Zhang

Deep Neural networks are efficient and flexible models that perform well for a variety of tasks such as image, speech recognition and natural language understanding. In particular, convolutional neural networks (CNN) generate a keen…

Machine Learning · Computer Science 2018-12-20 Yesmina Jaafra , Jean Luc Laurent , Aline Deruyver , Mohamed Saber Naceur

This paper introduces NSGA-Net -- an evolutionary approach for neural architecture search (NAS). NSGA-Net is designed with three goals in mind: (1) a procedure considering multiple and conflicting objectives, (2) an efficient procedure…

Computer Vision and Pattern Recognition · Computer Science 2019-04-22 Zhichao Lu , Ian Whalen , Vishnu Boddeti , Yashesh Dhebar , Kalyanmoy Deb , Erik Goodman , Wolfgang Banzhaf

In this work we present a deep learning approach to conduct hypothesis-free, transcriptomics-based matching of drugs for diseases. Our proposed neural network architecture is trained on approved drug-disease indications, taking as input the…

Genomics · Quantitative Biology 2023-03-22 Yannis Papanikolaou , Francesco Tuveri , Misa Ogura , Daniel O'Donovan

Black box deep learning models trained on genomic sequences excel at predicting the outcomes of different gene regulatory mechanisms. Therefore, interpreting these models may provide novel insights into the underlying biology, supporting…

Machine Learning · Computer Science 2024-07-18 Pedro Barbosa , Rosina Savisaar , Alcides Fonseca

In deep learning, performance is strongly affected by the choice of architecture and hyperparameters. While there has been extensive work on automatic hyperparameter optimization for simple spaces, complex spaces such as the space of deep…

Machine Learning · Statistics 2017-05-01 Renato Negrinho , Geoff Gordon

The computational prediction of a protein structure from its sequence generally relies on a method to assess the quality of protein models. Most assessment methods rank candidate models using heavily engineered structural features, defined…

Biomolecules · Quantitative Biology 2018-11-26 Georgy Derevyanko , Sergei Grudinin , Yoshua Bengio , Guillaume Lamoureux

Neural architecture search has shown its great potential in various areas recently. However, existing methods rely heavily on a black-box controller to search architectures, which suffers from the serious problem of lacking…

Machine Learning · Computer Science 2020-09-29 Xinyue Zheng , Peng Wang , Qigang Wang , Zhongchao Shi

Recently, graph neural networks (GNNs) have proved to be suitable in tasks on unstructured data. Particularly in tasks as community detection, node classification, and link prediction. However, most GNN models still operate with static…

Machine Learning · Computer Science 2019-06-07 Darwin Saire Pilco , Adín Ramírez Rivera

The design of neural network architectures is an important component for achieving state-of-the-art performance with machine learning systems across a broad array of tasks. Much work has endeavored to design and build architectures…

Computer Vision and Pattern Recognition · Computer Science 2018-09-13 Liang-Chieh Chen , Maxwell D. Collins , Yukun Zhu , George Papandreou , Barret Zoph , Florian Schroff , Hartwig Adam , Jonathon Shlens

Neural architecture search methods are able to find high performance deep learning architectures with minimal effort from an expert. However, current systems focus on specific use-cases (e.g. convolutional image classifiers and recurrent…

Machine Learning · Computer Science 2019-10-01 Renato Negrinho , Darshan Patil , Nghia Le , Daniel Ferreira , Matthew Gormley , Geoffrey Gordon

In the last decade the broad scope of complex networks has led to a rapid progress. In this area a particular interest has the study of community structures. The analysis of this type of structure requires the formalization of the intuitive…

Information Retrieval · Computer Science 2009-12-07 Vincenza Carchiolo , Alessandro Longheu , Michele Malgeri , Giuseppe Mangioni

Proteins are sequences of amino acids that serve as the basic building blocks of living organisms. Despite rapidly growing databases documenting structural and functional information for various protein sequences, our understanding of…

Biomolecules · Quantitative Biology 2025-01-06 Weihang Dai

Genetic algorithms are heuristic optimization techniques inspired by Darwinian evolution, which are characterized by successfully finding robust solutions for optimization problems. Here, we propose a subroutine-based quantum genetic…

Quantum Physics · Physics 2024-06-07 Rubén Ibarrondo , Giancarlo Gatti , Mikel Sanz

The diagnosis of cyber-physical systems aims to detect faulty behaviour, its root cause and a mitigation or even prevention policy. Therefore, diagnosis relies on a representation of the system's functional and faulty behaviour combined…

Machine Learning · Computer Science 2021-10-13 Nicolas Olivain , Philipp Tiefenbacher , Jens Kohl

Background Nucleotide sequences contain multiple codes responsible for organism's functioning and structure. They can be investigated by various signal processing methods. These techniques are well suited for indication of frequently…

Quantitative Methods · Quantitative Biology 2007-05-23 Simon Kogan