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Replication helps ensure that a genotype-phenotype association observed in a genome-wide association (GWA) study represents a credible association and is not a chance finding or an artifact due to uncontrolled biases. We discuss…

Methodology · Statistics 2010-10-26 Peter Kraft , Eleftheria Zeggini , John P. A. Ioannidis

Genetic diversity is central to the process of evolution. Both natural selection and random genetic drift are influenced by the level of genetic diversity of a population; selection acts on diversity while drift samples from it. At a given…

Populations and Evolution · Quantitative Biology 2024-11-12 Nikolas Vellnow , Toni I. Gossmann , David Waxman

We model a spatially detailed, two-sex population dynamics, to study the cost of ecological restoration. We assume that cost is proportional to the number of individuals introduced into a large habitat. We treat dispersal as homogeneous…

Populations and Evolution · Quantitative Biology 2014-03-20 F. Molnar , C. Caragine , T. Caraco , G. Korniss

We consider a population of haploid individuals reproducing sexually, i.e. for which the genome of each individual is a random mixture of the genome of its two parents. We assume that initially one individual carries a mutation at one…

Probability · Mathematics 2022-10-06 Camille Coron , Yves Le Jan

Background: Duplication of genes is important for evolution of molecular networks. Many authors have therefore considered gene duplication as a driving force in shaping the topology of molecular networks. In particular it has been noted…

Populations and Evolution · Quantitative Biology 2009-11-13 Jakob Enemark , Kim Sneppen

The goal of this note is to present a general approach to define the net reproduction function for a large class of nonlinear physiologically structured population models. In particular, we are going to show that this can be achieved in a…

Populations and Evolution · Quantitative Biology 2019-03-06 József Z. Farkas

Repetitions within a given genealogical tree provides some information about the degree of consanguineity of a population. They can be analyzed with techniques usually employed in statistical physics when dealing with fixed point…

Statistical Mechanics · Physics 2009-10-31 Paolo De Los Rios , Oscar Pla

Divergence between populations for a given trait can be driven by natural or sexual selection, interacting with migration behaviour. Mating preference for different phenotypes can lead to the emergence and persistence of differentiated…

Populations and Evolution · Quantitative Biology 2018-01-25 Charline Smadi , Helene Leman , Violaine Llaurens

Background: Hybridogenesis is a very interesting example of reproduction which seems to integrate the sexual and clonal processes in one system. In a case of frogs, described in the paper, two parental species - Rana lessonae and Rana…

Genomics · Quantitative Biology 2009-03-18 Mateusz Kula , Katarzyna Bonkowska , Maria Ogielska , Piotr Kierzkowski , Anna Zalesna , Stanislaw Cebrat

The Reduction Principle states that, near a stable equilibrium under fixed viability selection, a selectively neutral modifier allele that reduces recombination rate among selected loci is favored, whereas one that increases recombination…

Populations and Evolution · Quantitative Biology 2026-03-04 Elisa Heinrich-Mora , Marcus W. Feldman

Evolutionary graph theory has grown to be an area of intense study. Despite the amount of interest in the field, it seems to have grown separate from other subfields of population genetics and evolution. In the current work I introduce the…

Populations and Evolution · Quantitative Biology 2014-07-30 Wes Maciejewski

Genetic information and environmental factors determine the path of an individuals life and therefore, the evolution of its entire species. We have succeeded in proposing and studying a model that captures this idea. In our model, a…

Populations and Evolution · Quantitative Biology 2021-07-28 N. Abadi , G. Abramson

Modern developments in population dynamics emphasize the role of the turnover of individuals. In the new approaches stable population size is a dynamic equilibrium between different mortality and fecundity factors instead of an arbitrary…

Populations and Evolution · Quantitative Biology 2014-03-05 Krzysztof Argasinski , Mark Broom

Many mathematical models of evolution assume that all individuals experience the same environment. Here, we study the Moran process in heterogeneous environments. The population is of finite size with two competing types, which are exposed…

Populations and Evolution · Quantitative Biology 2018-12-19 Kamran Kaveh , Alex McAvoy , Martin A. Nowak

Standard neutral population genetics theory with a strictly fixed population size has important limitations. An alternative model that allows independently fluctuating population sizes and reproduces the standard neutral evolution is…

Populations and Evolution · Quantitative Biology 2017-03-08 Thiparat Chotibut , David R. Nelson

We model and study the genetic evolution and conservation of a population of diploid hermaphroditic organisms, evolving continuously in time and subject to resource competition. In the absence of mutations, the population follows a 3-type…

Probability · Mathematics 2012-07-23 Camille Coron

In evolutionary algorithms, the fitness of a population increases with time by mutating and recombining individuals and by a biased selection of more fit individuals. The right selection pressure is critical in ensuring sufficient…

Neural and Evolutionary Computing · Computer Science 2007-05-23 Marcus Hutter , Shane Legg

A novel mechanism for sympatric speciation that takes into account complex bio-processes within each individual organism is proposed. According to dynamical systems theory, organisms with identical genotypes can possess differentiated…

Condensed Matter · Physics 2007-05-23 Kunihiko Kaneko , Tetsuya Yomo

Heterozygote disadvantage is potentially a potent driver of population genetic divergence. Also referred to as underdominance, this phenomena describes a situation where a genetic heterozygote has a lower overall fitness than either…

Populations and Evolution · Quantitative Biology 2015-09-29 Áki J. Láruson , Floyd A. Reed

We propose a variation of the standard genetic algorithm that incorporates social interaction between the individuals in the population. Our goal is to understand the evolutionary role of social systems and its possible application as a…

Neural and Evolutionary Computing · Computer Science 2010-07-05 Rafeal Lahoz-Beltra , Gabriela Ochoa , Uwe Aickelin