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Human brains lie at the core of complex neurobiological systems, where the neurons, circuits, and subsystems interact in enigmatic ways. Understanding the structural and functional mechanisms of the brain has long been an intriguing pursuit…

Neurons and Cognition · Quantitative Biology 2022-07-26 Hejie Cui , Wei Dai , Yanqiao Zhu , Xiaoxiao Li , Lifang He , Carl Yang

It is essential to understand the complex structure of the human brain to develop new treatment approaches for neurodegenerative disorders (NDDs). This review paper comprehensively discusses the challenges associated with modelling the…

Neurons and Cognition · Quantitative Biology 2024-11-01 Hina Shaheen , Roderick Melnik

Brain disorders in the early and late life of humans potentially share pathological alterations in brain functions. However, the key evidence from neuroimaging data for pathological commonness remains unrevealed. To explore this hypothesis,…

Artificial Intelligence · Computer Science 2023-02-24 Mianxin Liu , Jingyang Zhang , Yao Wang , Yan Zhou , Fang Xie , Qihao Guo , Feng Shi , Han Zhang , Qian Wang , Dinggang Shen

Experimental research has shown that the brain's fast electrochemical dynamics, or neurodynamics (ND), is strongly stochastic, chaotic, and instanton (neuroavalanche)-dominated. It is also partly scale-invariant which has been loosely…

Neurons and Cognition · Quantitative Biology 2021-02-09 Igor V. Ovchinnikov , Skirmantas Janusonis

In this article we present the modeling of bi-stability view problems described by the activity or firing rates of two interacting population of neurons. Starting from the study of a complex system, the sys-tem of stochastic differential…

Analysis of PDEs · Mathematics 2014-11-27 S Mancini

We study the dynamics of bond-disordered Ising spin systems on random graphs with finite connectivity, using generating functional analysis. Rather than disorder-averaged correlation and response functions (as for fully connected systems),…

Disordered Systems and Neural Networks · Physics 2009-11-10 J. P. L. Hatchett , B. Wemmenhove , I. Perez Castillo , T. Nikoletopoulos , N. S. Skantzos , A. C. C. Coolen

Neural networks are high-dimensional nonlinear dynamical systems that process information through the coordinated activity of many connected units. Understanding how biological and machine-learning networks function and learn requires…

Neurons and Cognition · Quantitative Biology 2023-09-13 David G. Clark , L. F. Abbott , Ashok Litwin-Kumar

In neural circuits, statistical connectivity rules strongly depend on neuronal type. Here we study dynamics of neural networks with cell-type specific connectivity by extending the dynamic mean field method, and find that these networks…

Neurons and Cognition · Quantitative Biology 2015-02-24 Johnatan Aljadeff , Merav Stern , Tatyana O. Sharpee

Oscillatory activities are widely observed in specific frequency bands of recorded field potentials in different brain regions, and play critical roles in processing neural information. Understanding the structure of these oscillatory…

Neurons and Cognition · Quantitative Biology 2015-07-23 Pengsheng Zheng

In deep learning, neural networks serve as noisy channels between input data and its representation. This perspective naturally relates deep learning with the pursuit of constructing channels with optimal performance in information…

Machine Learning · Computer Science 2022-12-06 Kangyu Weng , Aohua Cheng , Ziyang Zhang , Pei Sun , Yang Tian

The layered structure of deep neural networks hinders the use of numerous analysis tools and thus the development of its interpretability. Inspired by the success of functional brain networks, we propose a novel framework for…

Machine Learning · Computer Science 2022-05-25 Ben Zhang , Zhetong Dong , Junsong Zhang , Hongwei Lin

Bifurcation theory is a powerful tool for studying how the dynamics of a neural network model depends on its underlying neurophysiological parameters. However, bifurcation theory has been developed mostly for smooth dynamical systems and…

Neurons and Cognition · Quantitative Biology 2019-01-16 Diego Fasoli , Stefano Panzeri

Function and dysfunctions of neural systems are tied to the temporal evolution of neural states. The current limitations in showing their causal role stem largely from the absence of tools capable of probing the brain's internal state in…

Neurons and Cognition · Quantitative Biology 2024-09-24 Ayesha Vermani , Matthew Dowling , Hyungju Jeon , Ian Jordan , Josue Nassar , Yves Bernaerts , Yuan Zhao , Steven Van Vaerenbergh , Il Memming Park

Recurrent neural networks (RNNs) provide a powerful approach in neuroscience to infer latent dynamics in neural populations and to generate hypotheses about the neural computations underlying behavior. However, past work has focused on…

Machine Learning · Computer Science 2025-10-30 Elia Torre , Michele Viscione , Lucas Pompe , Benjamin F Grewe , Valerio Mante

The brain is a complex organ characterized by heterogeneous patterns of structural connections supporting unparalleled feats of cognition and a wide range of behaviors. New noninvasive imaging techniques now allow these patterns to be…

Neurons and Cognition · Quantitative Biology 2020-04-03 Christopher W. Lynn , Danielle S. Bassett

Further analysis and experimentation is carried out in this paper for a chaotic dynamic model, viz. the Nonlinear Dynamic State neuron (NDS). The analysis and experimentations are performed to further understand the underlying dynamics of…

Neural and Evolutionary Computing · Computer Science 2014-08-19 Mohammad Alhawarat , Waleed Nazih , Mohammad Eldesouki

For complex life to evolve, a sophisticated nervous system for handling its complexities was fundamental. The demand resulted in the emergence of brain's computational facility, the neuronal network. This facet of the brain is attested…

Neurons and Cognition · Quantitative Biology 2019-09-16 Jahan N. Schad

An essential step toward understanding neural circuits is linking their structure and their dynamics. In general, this relationship can be almost arbitrarily complex. Recent theoretical work has, however, begun to identify some broad…

Neurons and Cognition · Quantitative Biology 2017-03-10 Gabriel Koch Ocker , Yu Hu , Michael A. Buice , Brent Doiron , Krešimir Josić , Robert Rosenbaum , Eric Shea-Brown

Mean field theory is a device to analyze the collective behavior of a dynamical system comprising many interacting particles. The theory allows to reduce the behavior of the system to the properties of a handful of parameters. In neural…

Neurons and Cognition · Quantitative Biology 2022-06-10 Giancarlo La Camera

Over the past two decades, complex network theory provided the ideal framework for investigating the intimate relationships between the topological properties characterizing the wiring of connections among a system's unitary components and…