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Particle picking is currently a critical step in the cryo-EM single particle reconstruction pipeline. Despite extensive work on this problem, for many data sets it is still challenging, especially for low SNR micrographs. We present the KLT…

Data Analysis, Statistics and Probability · Physics 2019-12-16 Amitay Eldar , Boris Landa , Yoel Shkolnisky

The past decade's "cryoEM revolution" has produced exponential growth in high-resolution structural data through advances in cryogenic electron microscopy (cryoEM) and tomography (cryoET). Deep learning integration into structural…

Quantitative Methods · Quantitative Biology 2025-07-29 Brady K. Zhou , Jason J. Hu , Jane K. J. Lee , Z. Hong Zhou , Demetri Terzopoulos

Semantic segmentation of electron microscopy (EM) is an essential step to efficiently obtain reliable morphological statistics. Despite the great success achieved using deep convolutional neural networks (CNNs), they still produce coarse…

Computer Vision and Pattern Recognition · Computer Science 2021-01-11 Zhimin Yuan , Xiaofen Ma , Jiajin Yi , Zhengrong Luo , Jialin Peng

The goal of cryo-electron microscopy (EM) is to reconstruct the 3-dimensional structure of a molecule from a collection of its 2-dimensional projected images. In this article, we show that the basic premise of cryo-EM --- patching together…

Computer Vision and Pattern Recognition · Computer Science 2017-04-25 Ke Ye , Lek-Heng Lim

Convolutional neural networks (CNNs) have gained tremendous success in solving complex inverse problems. The aim of this work is to develop a novel CNN framework to reconstruct video sequence of dynamic live cells captured using a…

Computer Vision and Pattern Recognition · Computer Science 2020-10-29 Thanh Nguyen , Yujia Xue , Yunzhe Li , Lei Tian , George Nehmetallah

Model pruning has become a useful technique that improves the computational efficiency of deep learning, making it possible to deploy solutions in resource-limited scenarios. A widely-used practice in relevant work assumes that a…

Machine Learning · Computer Science 2018-02-06 Jianbo Ye , Xin Lu , Zhe Lin , James Z. Wang

Deep learning models, especially convolutional neural networks (CNNs), have shown considerable promise for biomedical signals such as EEG-based seizure detection. However, these models come with challenges, primarily due to their size and…

Machine Learning · Computer Science 2025-09-08 Mounvik K , N Harshit

We present a novel approach for extracting 3D atomic-level information from transmission electron microscopy (TEM) images affected by significant noise. The approach is based on formulating depth estimation as a semantic segmentation…

Computer Vision and Pattern Recognition · Computer Science 2026-01-29 Matan Leibovich , Mai Tan , Ramon Manzorro , Adria Marcos-Morales , Sreyas Mohan , Peter A. Crozier , Carlos Fernandez-Granda

Reconstructing the detailed geometric structure of a face from a given image is a key to many computer vision and graphics applications, such as motion capture and reenactment. The reconstruction task is challenging as human faces vary…

Computer Vision and Pattern Recognition · Computer Science 2017-04-07 Elad Richardson , Matan Sela , Roy Or-El , Ron Kimmel

For the past few years, in the race between image steganography and steganalysis, deep learning has emerged as a very promising alternative to steganalyzer approaches based on rich image models combined with ensemble classifiers. A key…

Multimedia · Computer Science 2016-08-02 Jean-François Couchot , Raphaël Couturier , Christophe Guyeux , Michel Salomon

Cryo-EM is a powerful tool for understanding macromolecular structures, yet current methods for structure reconstruction are slow and computationally demanding. To accelerate research on pose estimation, we present CESPED, a new dataset…

Quantitative Methods · Quantitative Biology 2024-05-03 Ruben Sanchez-Garcia , Michael Saur , Javier Vargas , Carl Poelking , Charlotte M Deane

Transmission electron microscope (TEM) images are often corrupted by noise, hindering their interpretation. To address this issue, we propose a deep learning-based approach using simulated images. Using density functional theory…

Materials Science · Physics 2025-01-22 Jinwoong Chae , Sungwook Hong , Sungkyu Kim , Sungroh Yoon , Gunn Kim

Constructing atomic models from cryo-electron microscopy (cryo-EM) maps is a crucial yet intricate task in structural biology. While advancements in deep learning, such as convolutional neural networks (CNNs) and graph neural networks…

Quantitative Methods · Quantitative Biology 2024-11-01 Xin , Ma , Dong Si

Due to cellular heterogeneity, cell nuclei classification, segmentation, and detection from pathological images are challenging tasks. In the last few years, Deep Convolutional Neural Networks (DCNN) approaches have been shown…

Computer Vision and Pattern Recognition · Computer Science 2018-11-09 Md Zahangir Alom , Chris Yakopcic , Tarek M. Taha , Vijayan K. Asari

In cryo-electron microscopy (cryo-EM), a microscope generates a top view of a sample of randomly-oriented copies of a molecule. The problem of single particle reconstruction (SPR) from cryo-EM is to use the resulting set of noisy 2D…

Numerical Analysis · Mathematics 2014-09-16 Gene Katsevich , Alexander Katsevich , Amit Singer

Defect detection is a basic and essential task in automatic parts production, especially for automotive engine precision parts. In this paper, we propose a new idea to construct a deep convolutional network combining related knowledge of…

Computer Vision and Pattern Recognition · Computer Science 2018-10-30 Zhenshen Qu , Jianxiong Shen , Ruikun Li , Junyu Liu , Qiuyu Guan

In this work we propose a methodology for an automatic food classification system which recognizes the contents of the meal from the images of the food. We developed a multi-layered deep convolutional neural network (CNN) architecture that…

Computer Vision and Pattern Recognition · Computer Science 2017-11-22 Paritosh Pandey , Akella Deepthi , Bappaditya Mandal , N. B. Puhan

Automated cell detection and localization from microscopy images are significant tasks in biomedical research and clinical practice. In this paper, we design a new cell detection and localization algorithm that combines deep convolutional…

Computer Vision and Pattern Recognition · Computer Science 2018-10-09 Yao Xue , Gilbert Bigras , Judith Hugh , Nilanjan Ray

This paper considers a convolutional neural network transformation that reduces computation complexity and thus speedups neural network processing. Usage of convolutional neural networks (CNN) is the standard approach to image recognition…

Computer Vision and Pattern Recognition · Computer Science 2020-02-19 Elena Limonova , Alexander Sheshkus , Dmitry Nikolaev

Accurate thermal analysis of composites and porous media requires detailed characterization of local thermal properties in small scale. For some important applications such as lithium-ion batteries, changes in the properties during the…

Applied Physics · Physics 2020-10-06 Fazlolah Mohaghegh , Jayathi Murthy