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Following the rapidly growing digital image usage, automatic image categorization has become preeminent research area. It has broaden and adopted many algorithms from time to time, whereby multi-feature (generally, hand-engineered features)…

Computer Vision and Pattern Recognition · Computer Science 2017-05-12 Thangarajah Akilan , Q. M. Jonathan Wu , Wei Jiang

Studying the function of proteins is important for understanding the molecular mechanisms of life. The number of publicly available protein structures has increasingly become extremely large. Still, the determination of the function of a…

Machine Learning · Computer Science 2018-03-02 Wajdi Dhifli , Abdoulaye Baniré Diallo

Finding a template in a search image is an important task underlying many computer vision applications. Recent approaches perform template matching in a deep feature-space, produced by a convolutional neural network (CNN), which is found to…

Computer Vision and Pattern Recognition · Computer Science 2021-05-10 Bo Gao , M. W. Spratling

The Gene or DNA sequence in every cell does not control genetic properties on its own; Rather, this is done through translation of DNA into protein and subsequent formation of a certain 3D structure. The biological function of a protein is…

Computational Engineering, Finance, and Science · Computer Science 2019-05-30 Leila Khalatbari , Mohammad Reza Kangavari , Saeid Hosseini , Hongzhi Yin , Ngai-Man Cheung

Accurate classification of fine-grained images remains a challenge in backbones based on convolutional operations or self-attention mechanisms. This study proposes novel dual-current neural networks (DCNN), which combine the advantages of…

Computer Vision and Pattern Recognition · Computer Science 2024-05-08 Da Fu , Mingfei Rong , Eun-Hu Kim , Hao Huang , Witold Pedrycz

As proteins with similar structures often have similar functions, analysis of protein structures can help predict protein functions and is thus important. We consider the problem of protein structure classification, which computationally…

Machine Learning · Statistics 2019-10-08 Hongyu Guo , Khalique Newaz , Scott Emrich , Tijana Milenkovic , Jun Li

Sketch-based modeling strives to bring the ease and immediacy of drawing to the 3D world. However, while drawings are easy for humans to create, they are very challenging for computers to interpret due to their sparsity and ambiguity. We…

Graphics · Computer Science 2018-06-20 Johanna Delanoy , Mathieu Aubry , Phillip Isola , Alexei A. Efros , Adrien Bousseau

Protein-ligand scoring is an important step in a structure-based drug design pipeline. Selecting a correct binding pose and predicting the binding affinity of a protein-ligand complex enables effective virtual screening. Machine learning…

Machine Learning · Statistics 2020-10-19 Joshua Hochuli , Alec Helbling , Tamar Skaist , Matthew Ragoza , David Ryan Koes

Deep neural networks have enjoyed remarkable success for various vision tasks, however it remains challenging to apply CNNs to domains lacking a regular underlying structures such as 3D point clouds. Towards this we propose a novel…

Computer Vision and Pattern Recognition · Computer Science 2018-09-13 Yifan Xu , Tianqi Fan , Mingye Xu , Long Zeng , Yu Qiao

Predicting the structure of multi-protein complexes is a grand challenge in biochemistry, with major implications for basic science and drug discovery. Computational structure prediction methods generally leverage pre-defined structural…

Biomolecules · Quantitative Biology 2021-01-26 Stephan Eismann , Raphael J. L. Townshend , Nathaniel Thomas , Milind Jagota , Bowen Jing , Ron O. Dror

Click-Through Rate prediction is an important task in recommender systems, which aims to estimate the probability of a user to click on a given item. Recently, many deep models have been proposed to learn low-order and high-order feature…

Information Retrieval · Computer Science 2019-04-30 Bin Liu , Ruiming Tang , Yingzhi Chen , Jinkai Yu , Huifeng Guo , Yuzhou Zhang

Proteins perform essential biological functions, and accurate classification of their sequences is critical for understanding structure-function relationships, enzyme mechanisms, and molecular interactions. This study presents a deep…

Quantitative Methods · Quantitative Biology 2025-11-19 Pratik Chakraborty , Aryan Bhargava

In this work, we investigate the value of employing deep learning for the task of wireless signal modulation recognition. Recently in [1], a framework has been introduced by generating a dataset using GNU radio that mimics the imperfections…

Machine Learning · Computer Science 2018-01-08 Xiaoyu Liu , Diyu Yang , Aly El Gamal

Protein secondary structure (SS) prediction is important for studying protein structure and function. When only the sequence (profile) information is used as input feature, currently the best predictors can obtain ~80% Q3 accuracy, which…

Biomolecules · Quantitative Biology 2015-12-14 Sheng Wang , Jian Peng , Jianzhu Ma , Jinbo Xu

Applying deep learning concepts from image detection and graph theory has greatly advanced protein-ligand binding affinity prediction, a challenge with enormous ramifications for both drug discovery and protein engineering. We build upon…

Biomolecules · Quantitative Biology 2023-12-05 Gregory W. Kyro , Rafael I. Brent , Victor S. Batista

Deep Convolutional Neural Networks (CNNs) have significantly advanced deep learning, driving breakthroughs in computer vision, natural language processing, medical diagnosis, object detection, and speech recognition. Architectural…

Computer Vision and Pattern Recognition · Computer Science 2025-03-24 Saddam Hussain Khan , Rashid Iqbal

The accurate prediction of changes in protein stability under multiple amino acid substitutions is essential for realising true in-silico protein re-design. To this purpose, we propose improvements to state-of-the-art Deep learning (DL)…

Biomolecules · Quantitative Biology 2023-06-01 Sebastien Boyer , Sam Money-Kyrle , Oliver Bent

Protein interactions are important in a broad range of biological processes. Traditionally, computational methods have been developed to automatically predict protein interface from hand-crafted features. Recent approaches employ deep…

Machine Learning · Computer Science 2020-07-21 Yi Liu , Hao Yuan , Lei Cai , Shuiwang Ji

Object segmentation and structure localization are important steps in automated image analysis pipelines for microscopy images. We present a convolution neural network (CNN) based deep learning architecture for segmentation of objects in…

Computer Vision and Pattern Recognition · Computer Science 2019-01-24 Shan E Ahmed Raza , Linda Cheung , Muhammad Shaban , Simon Graham , David Epstein , Stella Pelengaris , Michael Khan , Nasir M. Rajpoot

In this paper, we propose a new deep framework which predicts facial attributes and leverage it as a soft modality to improve face identification performance. Our model is an end to end framework which consists of a convolutional neural…

Computer Vision and Pattern Recognition · Computer Science 2018-05-02 Fariborz Taherkhani , Nasser M. Nasrabadi , Jeremy Dawson