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Phase-separated biomolecular condensates with liquid-like properties play a key role in the organization and compartmentalization of the intracellular environment. Condensate-mediated capillary forces acting on membranes drive…

This paper considers membranes of globular structure in the framework of the cell model technique. Coupled micropolar and Brinkman-type equations are used to model the flow of micropolar fluid through a spherical cell, consisting of solid…

Fluid Dynamics · Physics 2020-05-05 D. Yu. Khanukaeva

In this paper, phase field models are developed for multi-component vesicle membranes with different lipid compositions and membranes with free boundary. These models are used to simulate the deformation of membranes under the elastic…

Biological Physics · Physics 2007-05-23 Xiaoqiang Wang , Qiang Du

We present a model for cell growth, division and packing under soft constraints that arise from the deformability of the cells as well as of a membrane that encloses them. Our treatment falls within the framework of diffuse interface…

Cell Behavior · Quantitative Biology 2019-01-09 J. Jiang , K. Garikipati , S. Rudraraju

Biological cells utilize membranes and liquid-like droplets, known as biomolecular condensates, to structure their interior. The interaction of droplets and membranes, despite being involved in several key biological processes, is so far…

Soft Condensed Matter · Physics 2024-02-21 Marcel Mokbel , Dominic Mokbel , Susanne Liese , Christoph A. Weber , Sebastian Aland

The fundamental processes of biological development are governed by multiple signaling molecules that create non-uniform concentration profiles known as morphogen gradients. It is widely believed that the establishment of morphogen…

Biological Physics · Physics 2015-06-18 Hamid Teimouri , Anatoly B. Kolomeisky

We investigate the hydrodynamic effects on the dynamics of critical concentration fluctuations in multicomponent fluid membranes. Two geometrical cases are considered; (i) confined membrane case and (ii) supported membrane case. We…

Soft Condensed Matter · Physics 2010-11-29 Sanoop Ramachandran , Shigeyuki Komura , Kazuhiko Seki , Masayuki Imai

Motivated by recent experiments on biomimetic membranes exposed to several aqueous phases, we theoretically study the morphology of a membrane in contact with a liquid droplet formed via aqueous phase separation. We concentrate on membranes…

Soft Condensed Matter · Physics 2012-02-07 Halim Kusumaatmaja , Reinhard Lipowsky

We study the diffusion of a linear polymer in the presence of permeable membranes without excluded volume interactions, using scaling theory and Monte Carlo simulations. We find that the average time it takes for a chain with polymerization…

Condensed Matter · Physics 2016-08-31 Hyoungsoo Yoon , J. M. Deutsch

Recent experiments by Kantsler et. al. (2007) have shown that the relaxational dynamics of a vesicle in external elongation flow is accompanied by the formation of wrinkles on a membrane. Motivated by these experiments we present a theory…

Soft Condensed Matter · Physics 2013-05-29 K. S. Turitsyn , S. S. Vergeles

Cell spreading is investigated at various scales in order to understand motility of living cells which is essential for a range of physiological activities in higher organisms as well as in microbes. At a microscopic scale, it has been seen…

Cell Behavior · Quantitative Biology 2009-11-13 A. Bhattacharyay

Spatial organisation is a hallmark of all living cells, and recreating it in model systems is a necessary step in the creation of synthetic cells. It is therefore of both fundamental and practical interest to better understand the basic…

Biological Physics · Physics 2017-12-19 Jaime Agudo-Canalejo , Ramin Golestanian

The evolution of various competing cell types in tissues, and the resulting persistent tissue population, is studied numerically and analytically in a particle-based model of active tissues. Mutations change the properties of cells in…

Populations and Evolution · Quantitative Biology 2024-06-03 Tobias Büscher , Nirmalendu Ganai , Gerhard Gompper , Jens Elgeti

In silico, cell based approaches for modeling biological morphogenesis are used to test and validate our understanding of the biological and mechanical process that are at work during the growth and the organization of multi-cell tissues.…

Biological Physics · Physics 2026-01-06 Raphaël Conradin , Christophe Coreixas , Jonas Latt , Bastien Chopard

Polymer association at liquid-liquid interfaces is a promising way to spontaneously obtain soft self-healing membranes. In the case of reversible bonding between two polymers, the macromolecules are mobile everywhere within the membrane and…

The interplay of membrane proteins is vital for many biological processes, such as cellular transport, cell division, and signal transduction between nerve cells. Theoretical considerations have led to the idea that the membrane itself…

Soft Condensed Matter · Physics 2016-11-28 Casper van der Wel , Afshin Vahid , Anđela Šarić , Timon Idema , Doris Heinrich , Daniela J. Kraft

We study the shapes of elastic membranes under the simultaneous exertion of tensile and compressive forces when the translational symmetry along the tension direction is broken. We predict a multitude of novel morphological phases in…

Soft Condensed Matter · Physics 2015-05-13 Benny Davidovitch

We study dynamics of a membrane and its matrix regularisation. We present the matrix regularisation for a membrane propagating in a curved space-time geometry in the presence of an arbitrary 3-form field. In the matrix regularisation, we…

High Energy Physics - Theory · Physics 2010-11-10 Qasem Exirifard

Biomembranes play a central role in various phenomena like locomotion of cells, cell-cell interactions, packaging of nutrients, and in maintaining organelle morphology and functionality. During these processes, the membranes undergo…

Quantitative Methods · Quantitative Biology 2021-12-01 Debabrata Auddya , Xiaoxuan Zhang , Rahul Gulati , Ritvik Vasan , Krishna Garikipati , Padmini Rangamani , Shiva Rudraraju

Curvature in biological membranes can be generated by a variety of different molecular mechanisms such as protein scaffolding, lipid or protein asymmetry, cytoskeletal forces, etc. These mechanisms have the net effect of generating stresses…