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In deep neural networks, better results can often be obtained by increasing the complexity of previously developed basic models. However, it is unclear whether there is a way to boost performance by decreasing the complexity of such models.…

Machine Learning · Computer Science 2022-06-07 Junran Wu , Shangzhe Li , Jianhao Li , Yicheng Pan , Ke Xu

We present MEDUSA, an integrative method for learning motif models of transcription factor binding sites by incorporating promoter sequence and gene expression data. We use a modern large-margin machine learning approach, based on boosting,…

Genomics · Quantitative Biology 2007-05-23 Manuel Middendorf , Anshul Kundaje , Mihir Shah , Yoav Freund , Chris H. Wiggins , Christina Leslie

Deep learning is popular as an end-to-end framework extracting the prominent features and performing the classification also. In this paper, we extensively investigate deep networks as an alternate to feature encoding technique of low level…

Machine Learning · Computer Science 2018-11-15 Bhalaji Nagarajan , V Ramana Murthy Oruganti

This paper proposes a convolutional neural network that can fuse high-level prior for semantic image segmentation. Motivated by humans' vision recognition system, our key design is a three-layer generative structure consisting of high-level…

Computer Vision and Pattern Recognition · Computer Science 2015-11-24 Haitian Zheng , Yebin Liu , Mengqi Ji , Feng Wu , Lu Fang

The interpretability of neural networks has recently received extensive attention. Previous prototype-based explainable networks involved prototype activation in both reasoning and interpretation processes, requiring specific explainable…

Computer Vision and Pattern Recognition · Computer Science 2022-11-22 Yitao Peng , Yihang Liu , Longzhen Yang , Lianghua He

In the rapidly evolving landscape of genomics, deep learning has emerged as a useful tool for tackling complex computational challenges. This review focuses on the transformative role of Large Language Models (LLMs), which are mostly based…

Deep learning on graphs and in particular, graph convolutional neural networks, have recently attracted significant attention in the machine learning community. Many of such techniques explore the analogy between the graph Laplacian…

Machine Learning · Computer Science 2018-02-07 Federico Monti , Karl Otness , Michael M. Bronstein

Recent advancements in deep learning-based modeling of molecules promise to accelerate in silico drug discovery. A plethora of generative models is available, building molecules either atom-by-atom and bond-by-bond or fragment-by-fragment.…

When we are faced with challenging image classification tasks, we often explain our reasoning by dissecting the image, and pointing out prototypical aspects of one class or another. The mounting evidence for each of the classes helps us…

Machine Learning · Computer Science 2020-01-01 Chaofan Chen , Oscar Li , Chaofan Tao , Alina Jade Barnett , Jonathan Su , Cynthia Rudin

Structure based ligand discovery is one of the most successful approaches for augmenting the drug discovery process. Currently, there is a notable shift towards machine learning (ML) methodologies to aid such procedures. Deep learning has…

Machine Learning · Statistics 2018-06-12 Marta M. Stepniewska-Dziubinska , Piotr Zielenkiewicz , Pawel Siedlecki

Deep learning based methods have seen a massive rise in popularity for hyperspectral image classification over the past few years. However, the success of deep learning is attributed greatly to numerous labeled samples. It is still very…

Computer Vision and Pattern Recognition · Computer Science 2021-06-30 Bing Liu , Anzhu Yu , Pengqiang Zhang , Lei Ding , Wenyue Guo , Kuiliang Gao , Xibing Zuo

Deep convolutional neural networks have proven their effectiveness, and have been acknowledged as the most dominant method for image classification. However, a severe drawback of deep convolutional neural networks is poor explainability.…

Computer Vision and Pattern Recognition · Computer Science 2025-03-27 Bin Wang , Wenbin Pei , Bing Xue , Mengjie Zhang

Recent advances in deep learning, especially deep convolutional neural networks (CNNs), have led to significant improvement over previous semantic segmentation systems. Here we show how to improve pixel-wise semantic segmentation by…

Computer Vision and Pattern Recognition · Computer Science 2018-06-04 Panqu Wang , Pengfei Chen , Ye Yuan , Ding Liu , Zehua Huang , Xiaodi Hou , Garrison Cottrell

Graph generation techniques are increasingly being adopted for drug discovery. Previous graph generation approaches have utilized relatively small molecular building blocks such as atoms or simple cycles, limiting their effectiveness to…

Machine Learning · Computer Science 2020-04-21 Wengong Jin , Regina Barzilay , Tommi Jaakkola

Non-Hermitian topological phases can produce some remarkable properties, compared with their Hermitian counterpart, such as the breakdown of conventional bulk-boundary correspondence and the non-Hermitian topological edge mode. Here, we…

Applied Physics · Physics 2024-02-16 Xi Chen , Jinyang Sun , Xiumei Wang , Hengxuan Jiang , Dandan Zhu , Xingping Zhou

Plant phenotyping refers to a quantitative description of the plants properties, however in image-based phenotyping analysis, our focus is primarily on the plants anatomical, ontogenetical and physiological properties.This technique…

Computer Vision and Pattern Recognition · Computer Science 2022-10-25 Petros N. Tamvakis , Chairi Kiourt , Alexandra D. Solomou , George Ioannakis , Nestoras C. Tsirliganis

We propose a Deep Texture Encoding Network (Deep-TEN) with a novel Encoding Layer integrated on top of convolutional layers, which ports the entire dictionary learning and encoding pipeline into a single model. Current methods build from…

Computer Vision and Pattern Recognition · Computer Science 2016-12-12 Hang Zhang , Jia Xue , Kristin Dana

Deep learning models are favored in many research and industry areas and have reached the accuracy of approximating or even surpassing human level. However they've long been considered by researchers as black-box models for their…

Machine Learning · Computer Science 2020-10-16 Xiaojian Wang , Jingyuan Wang , Ke Tang

Recently, deep learning-based denoising approaches have led to dramatic improvements in low sample-count Monte Carlo rendering. These approaches are aimed at path tracing, which is not ideal for simulating challenging light transport…

Graphics · Computer Science 2020-04-28 Shilin Zhu , Zexiang Xu , Henrik Wann Jensen , Hao Su , Ravi Ramamoorthi

Graph neural networks (GNNs) have emerged as powerful tools for learning protein structures by capturing spatial relationships at the residue level. However, existing GNN-based methods often face challenges in learning multiscale…

Machine Learning · Computer Science 2026-02-03 Shih-Hsin Wang , Yuhao Huang , Taos Transue , Justin Baker , Jonathan Forstater , Thomas Strohmer , Bao Wang
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