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Missing data often exists in real-world datasets, requiring significant time and effort for data repair to learn accurate models. In this paper, we show that imputing all missing values is not always necessary to achieve an accurate ML…

Machine Learning · Computer Science 2026-03-19 Cheng Zhen , Prayoga , Nischal Aryal , Arash Termehchy , Garrett Biwer , Lubna Alzamil

Machine learning holds great promise for advancing the field of medicine, with electronic health records (EHRs) serving as a primary data source. However, EHRs are often sparse and contain missing data due to various challenges and…

Machine Learning · Computer Science 2026-02-25 Jun Han , Josue Nassar , Sanjit Singh Batra , Aldo Cordova-Palomera , Vijay Nori , Robert E. Tillman

This chapter addresses important steps during the quality assurance and control of RWD, with particular emphasis on the identification and handling of missing values. A gentle introduction is provided on common statistical and machine…

Methodology · Statistics 2021-11-01 Dawei Liu , Hanne I. Oberman , Johanna Muñoz , Jeroen Hoogland , Thomas P. A. Debray

We characterize the structure and origins of missingness for 159 cross-sectional return predictors and study missing value handling for portfolios constructed using machine learning. Simply imputing with cross-sectional means performs well…

Methodology · Statistics 2024-01-15 Andrew Y. Chen , Jack McCoy

Balancing the distributions of the confounders across the exposure levels in an observational study through matching or weighting is an accepted method to control for confounding due to these variables when estimating the association…

Methodology · Statistics 2021-08-24 Farhad Pishgar , Noah Greifer , Clémence Leyrat , Elizabeth Stuart

Techniques such as clusterization, neural networks and decision making usually rely on algorithms that are not well suited to deal with missing values. However, real world data frequently contains such cases. The simplest solution is to…

Machine Learning · Computer Science 2016-08-16 Davi E. N. Frossard , Igor O. Nunes , Renato A. Krohling

Predictive mean matching (PMM) is a popular imputation strategy that imputes missing values by borrowing observed values from other cases with similar expectations. We show that, unlike other imputation strategies, PMM is not guaranteed to…

Methodology · Statistics 2025-07-01 Paul T. von Hippel

Data imputation is a critical step in data pre-processing, particularly for datasets with missing or unreliable values. This study introduces a novel quantum-inspired imputation framework evaluated on the UCI Diabetes dataset, which…

Quantum Physics · Physics 2025-05-13 Nishikanta Mohanty , Bikash K. Behera , Badshah Mukherjee , Christopher Ferrie

Missing values often limit the usage of data analysis or cause falsification of results. Therefore, methods of missing value imputation (MVI) are of great significance. However, in general, there is no universal, fair MVI method for…

Databases · Computer Science 2025-07-29 Valerie Restat , Kai Tejkl , Uta Störl

Imputing missing values is common practice in label-free quantitative proteomics. Imputation aims at replacing a missing value with a user-defined one. However, the imputation itself may not be optimally considered downstream of the…

Methodology · Statistics 2022-09-08 Marie Chion , Christine Carapito , Frédéric Bertrand

Statistical analysis of large data sets offers new opportunities to better understand many processes. Yet, data accumulation often implies relaxing acquisition procedures or compounding diverse sources. As a consequence, such data sets…

Applications · Statistics 2018-05-01 François Husson , Julie Josse , Balasubramanian Narasimhan , Geneviève Robin

While data are the primary fuel for machine learning models, they often suffer from missing values, especially when collected in real-world scenarios. However, many off-the-shelf machine learning models, including artificial neural network…

Missing data is a pervasive issue in statistical analyses, affecting the reliability and validity of research across diverse scientific disciplines. Failure to adequately address missing data can lead to biased estimates and consequently…

Methodology · Statistics 2025-05-06 Asmaa Ahmad , Eric J Rose , Michael Roy , Edward Valachovic

The ICH E9(R1) Addendum (International Council for Harmonization 2019) suggests treatment-policy as one of several strategies for addressing intercurrent events such as treatment withdrawal when defining an estimand. This strategy requires…

Methodology · Statistics 2023-08-28 Suzie Cro , James H Roger , James R Carpenter

When fitting a generalized linear model -- such as a linear regression, a logistic regression, or a hierarchical linear model -- analysts often wonder how to handle missing values of the dependent variable Y. If missing values have been…

Methodology · Statistics 2017-03-27 Paul T. von Hippel

We introduce a novel profile-based patient clustering model designed for clinical data in healthcare. By utilizing a method grounded on constrained low-rank approximation, our model takes advantage of patients' clinical data and digital…

Machine Learning · Computer Science 2023-08-24 Dongjin Choi , Andy Xiang , Ozgur Ozturk , Deep Shrestha , Barry Drake , Hamid Haidarian , Faizan Javed , Haesun Park

Multiple imputation is a common approach for dealing with missing values in statistical databases. The imputer fills in missing values with draws from predictive models estimated from the observed data, resulting in multiple, completed…

Computation · Statistics 2018-08-30 Olanrewaju Akande , Fan Li , Jerome Reiter

We present a nonparametric Bayesian joint model for multivariate continuous and categorical variables, with the intention of developing a flexible engine for multiple imputation of missing values. The model fuses Dirichlet process mixtures…

Applications · Statistics 2015-10-14 Jared S. Murray , Jerome P. Reiter

Handling missing values in tabular datasets presents a significant challenge in training and testing artificial intelligence models, an issue usually addressed using imputation techniques. Here we introduce "Not Another Imputation Method"…

Machine Learning · Computer Science 2026-03-13 Camillo Maria Caruso , Paolo Soda , Valerio Guarrasi

Imputation of missing values is a strategy for handling non-responses in surveys or data loss in measurement processes, which may be more effective than ignoring them. When the variable represents a count, the literature dealing with this…

Applications · Statistics 2020-07-31 Gilma Hernández-Herrera , Albert Navarro , David Moriña