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Novel multimodal imaging methods are capable of generating extensive, super high resolution datasets for preclinical research. Yet, a massive lack of annotations prevents the broad use of deep learning to analyze such data. So far, existing…

Image and Video Processing · Electrical Eng. & Systems 2021-04-26 Izabela Horvath , Johannes C. Paetzold , Oliver Schoppe , Rami Al-Maskari , Ivan Ezhov , Suprosanna Shit , Hongwei Li , Ali Ertuerk , Bjoern H. Menze

In recent years, several models have improved the capacity to generate synthetic tabular datasets. However, such models focus on synthesizing simple columnar tables and are not useable on real-life data with complex structures. This paper…

Machine Learning · Computer Science 2022-02-07 Luca Canale , Nicolas Grislain , Grégoire Lothe , Johan Leduc

The advances of next-generation sequencing technology have accelerated study of the microbiome and stimulated the high throughput profiling of metagenomes. The large volume of sequenced data has encouraged the rise of various studies for…

Methodology · Statistics 2019-04-30 Qiwei Li , Shuang Jiang , Andrew Y. Koh , Guanghua Xiao , Xiaowei Zhan

Taxonomic classification in biodiversity research involves organizing biological specimens into structured hierarchies based on evidence, which can come from multiple modalities such as images and genetic information. We investigate whether…

Despite extensive research spanning several decades, class imbalance is still considered a profound difficulty for both machine learning and deep learning models. While data oversampling is the foremost technique to address this issue,…

Machine Learning · Computer Science 2025-02-12 Sukumar Kishanthan , Asela Hevapathige

Stacking (or stacked generalization) is an ensemble learning method with one main distinctiveness from the rest: even though several base models are trained on the original data set, their predictions are further used as input data for one…

Machine Learning · Computer Science 2024-04-19 Ilya Ploshchik , Angelos Chatzimparmpas , Andreas Kerren

Data sets are growing in complexity thanks to the increasing facilities we have nowadays to both generate and store data. This poses many challenges to machine learning that are leading to the proposal of new methods and paradigms, in order…

Machine Learning · Computer Science 2018-12-04 Irene Córdoba , Concha Bielza , Pedro Larrañaga

Deep learning-based antimicrobial peptide (AMP) discovery faces critical challenges such as limited controllability, lack of representations that efficiently model antimicrobial properties, and low experimental hit rates. To address these…

DNA microarrays are a relatively new technology that can simultaneously measure the expression level of thousands of genes. They have become an important tool for a wide variety of biological experiments. One of the most common goals of DNA…

Methodology · Statistics 2013-07-02 Eric Bair

The detection of genomic structural variation (SV) has advanced tremendously in recent years due to progress in high-throughput sequencing technologies. Novel sequence insertions, insertions without similarity to a human reference genome,…

Genomics · Quantitative Biology 2015-04-09 Birte Kehr , Páll Melsted , Bjarni V. Halldórsson

Within the paradigm of metamaterials and metasurfaces, electromagnetic properties of composite materials can be engineered by shaping or modulating their constituents, so-called meta-atoms. Synthesis and analysis of complex-shape meta-atoms…

Optics · Physics 2019-09-04 Viktar Asadchy , Sergei Tretyakov

Metagenomics is an emerging field of molecular biology concerned with analyzing the genomes of environmental samples comprising many different diverse organisms. Given the nature of metagenomic data, one usually has to sequence the genomic…

Genomics · Quantitative Biology 2013-11-20 Jonathan G. Ligo , Minji Kim , Amin Emad , Olgica Milenkovic , Venugopal V. Veeravalli

Since data is the fuel that drives machine learning models, and access to labeled data is generally expensive, semi-supervised methods are constantly popular. They enable the acquisition of large datasets without the need for too many…

Machine Learning · Computer Science 2023-01-12 Jędrzej Kozal , Michał Woźniak

Simulated microbial communities are used in benchmarking microbial abundance estimators and other bioinformatic utilities. To match current data scales, large simulated samples are needed, and many. The speed of current implementations…

Quantitative Methods · Quantitative Biology 2025-11-20 Amit Lavon

Image synthesis is currently one of the most addressed image processing topic in computer vision and deep learning fields of study. Researchers have tackled this problem focusing their efforts on its several challenging problems, e.g. image…

Machine Learning · Computer Science 2020-06-26 Tomaso Fontanini , Eleonora Iotti , Luca Donati , Andrea Prati

As the sequencing costs are decreasing, there is great incentive to perform large scale association studies to increase power of detecting new variants. Federated association testing among different institutions is a viable solution for…

Methodology · Statistics 2022-10-04 Wentao Li , Han Chen , Xiaoqian Jiang , Arif Harmanci

Antibiotic resistance presents a growing global health crisis, demanding new therapeutic strategies that target novel bacterial mechanisms. Recent advances in protein structure prediction and machine learning-driven molecule generation…

Biomolecules · Quantitative Biology 2025-05-22 Maximilian G. Schuh , Joshua Hesse , Stephan A. Sieber

This paper describes a new method, Combi-bootstrap, to exploit existing taggers and lexical resources for the annotation of corpora with new tagsets. Combi-bootstrap uses existing resources as features for a second level machine learning…

Computation and Language · Computer Science 2007-05-23 Jakub Zavrel , Walter Daelemans

The future of computing systems is inevitably embracing a disaggregated and composable pattern: from clusters of computers to pools of resources that can be dynamically combined together and tailored around applications requirements.…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-07-02 Christian Pinto , Dong Li , Thaleia Dimitra Doudali , Christina Giannoula , Jie Ren

Phylogenetic placement refers to a family of tools and methods to analyze, visualize, and interpret the tsunami of metagenomic sequencing data generated by high-throughput sequencing. Compared to alternative (e. g., similarity-based)…

Populations and Evolution · Quantitative Biology 2025-01-09 Lucas Czech , Alexandros Stamatakis , Micah Dunthorn , Pierre Barbera