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Biological molecular machines are enzymes that simultaneously catalyze two processes, one donating free energy and second accepting it. Recent studies show that most native protein enzymes have a rich stochastic dynamics that often…

Biological Physics · Physics 2018-12-21 Michal Kurzynski , Przemyslaw Chelminiak

Small thermodynamic systems exhibit peculiar behavior different from that observed in long-scale systems. Non-equilibrium processes taking place in those systems are strongly influenced by the presence of fluctuations which can be large.…

Statistical Mechanics · Physics 2007-05-23 J. M. Rubi

The Free-Energy-Principle (FEP) is an influential and controversial theory which postulates a deep and powerful connection between the stochastic thermodynamics of self-organization and learning through variational inference. Specifically,…

Artificial Intelligence · Computer Science 2021-10-05 Beren Millidge , Anil Seth , Christopher L Buckley

The relationship between the thermodynamic and computational characteristics of dynamical physical systems has been a major theoretical interest since at least the 19th century, and has been of increasing practical importance as the…

The Landauer principle bridges the energetic cost and information processing, showing that irreversible computation inevitably demands energy dissipation. As energy demands from computation continue to rise, approximate computing has…

Statistical Mechanics · Physics 2026-05-26 Yoshihiko Hasegawa

Landauer's principle asserts that any computation has an unavoidable energy cost that grows proportionally to its degree of logical irreversibility. But even a logically reversible operation, when run on a physical processor that operates…

Quantum Physics · Physics 2021-05-31 Giulio Chiribella , Yuxiang Yang , Renato Renner

Jarzynski's identity for the free energy difference between two equilibrium states can be viewed as a special case of a more general procedure based on phase space mappings. Solving a system's equation of motion by approximate means…

Statistical Mechanics · Physics 2009-11-11 Wolfgang Lechner , Harald Oberhofer , Christoph Dellago , Phillip L. Geissler

Motivated by the recent proposed models of the information engine [D. Mandal and C. Jarzynski, Proc. Natl. Acad. Sci. 109, 11641 (2012)] and the information refrigerator [D. Mandal, H. T. Quan, and C. Jarzynski, Phys. Rev. Lett. 111, 030602…

Statistical Mechanics · Physics 2015-06-30 Yuansheng Cao , Zongping Gong , H. T. Quan

Despite being optimized, the information processing of biological organisms exhibits significant variability in its complexity and capability. One potential source of this diversity is the limitation of resources required for information…

Biological Physics · Physics 2025-10-21 Takehiro Tottori , Tetsuya J. Kobayashi

This study examines a new formulation of non-equilibrium thermodynamics, which gives a conditional derivation of the ``maximum entropy production'' (MEP) principle for flow and/or chemical reaction systems at steady state. The analysis uses…

Populations and Evolution · Quantitative Biology 2009-08-25 Robert K. Niven

A central endeavor of thermodynamics is the measurement of free energy changes. Regrettably, although we can measure the free energy of a system in thermodynamic equilibrium, typically all we can say about the free energy of a…

Statistical Mechanics · Physics 2012-04-10 David A. Sivak , Gavin E. Crooks

In view of the relation between information and thermodynamics we investigate how much information about an external protocol can be stored in the memory of a stochastic measurement device given an energy budget. We consider a layered…

Quantitative Methods · Quantitative Biology 2015-07-28 Stefano Bo , Marco Del Giudice , Antonio Celani

Information is central to thermodynamics, providing the grounds to the formulation of the theory in powerful abstract statistical terms. One must not forget, however, that, as put by Landauer, {\it information is physical}. This means that…

Quantum Physics · Physics 2019-05-01 T. Croucher , J. Wright , A. R. R. Carvalho , S. M. Barnett , J. A. Vaccaro

The concept of autonomy is fundamental for understanding biological organization and the evolutionary transitions of living systems. Understanding how a system constitutes itself as an individual, cohesive, self-organized entity is a…

Neurons and Cognition · Quantitative Biology 2019-02-07 Miguel Aguilera , Ezequiel Di Paolo

We consider the thermodynamics of chemical coupling from the viewpoint of free energy transduction efficiency. In contrast to an external parameter-driven stochastic energetics setup, the dynamic change of the equilibrium distribution…

Statistical Mechanics · Physics 2022-06-28 Kyogo Kawaguchi , Masaki Sano

There are many functional contexts where it is desirable to maintain a mesoscopic system in a nonequilibrium state. However, such control requires an inherent energy dissipation. In this article, we unify and extend a number of works on the…

Statistical Mechanics · Physics 2017-11-07 Jordan M. Horowitz , Jeremy L. England

Self-propulsion allows living systems to display unusual collective behavior. Unlike passive systems in thermal equilibrium, active matter systems are not constrained by conventional thermodynamic laws. A question arises however as to what…

Soft Condensed Matter · Physics 2015-03-18 Sho C. Takatori , John F. Brady

Accurate information processing is crucial both in technology and in nature. To achieve it, any information processing system needs an initial supply of resources away from thermal equilibrium. Here we establish a fundamental limit on the…

Quantum Physics · Physics 2022-12-14 Giulio Chiribella , Fei Meng , Renato Renner , Man-Hong Yung

Life depends as much on the flow of information as on the flow of energy. Here we review the many efforts to make this intuition precise. Starting with the building blocks of information theory, we explore examples where it has been…

Quantitative Methods · Quantitative Biology 2014-12-31 Gašper Tkačik , William Bialek

Free energy and entropy are examined in detail from the standpoint of classical thermodynamics. The approach is logically based on the fact that thermodynamic work is mediated by thermal energy through the tendency for nonthermal energy to…

Physics Education · Physics 2015-06-26 Clinton D. Stoner
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