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We introduce a new computational problem, the BackboneDiscovery problem, which encapsulates both functional and structural aspects of network analysis. While the topology of a typical road network has been available for a long time (e.g.,…

Social and Information Networks · Computer Science 2015-08-18 Sanjay Chawla , Kiran Garimella , Aristides Gionis , Dominic Tsang

Several works based on Generative Adversarial Networks (GAN) have been recently proposed to predict a set of medical images from a single modality (e.g, FLAIR MRI from T1 MRI). However, such frameworks are primarily designed to operate on…

Machine Learning · Computer Science 2020-09-24 Alaa Bessadok , Mohamed Ali Mahjoub , Islem Rekik

Demystifying effective connectivity among neuronal populations has become the trend to understand the brain mechanisms of Parkinson's disease, schizophrenia, mild traumatic brain injury, and many other unlisted neurological diseases.…

Quantitative Methods · Quantitative Biology 2019-09-27 Po-Ya Hsu

Neurodegeneration affects cortical gray matter leading to loss of cortical mantle volume. As a result of such volume loss, the geometrical arrangement of the regions on the cortical surface is expected to be altered in comparison to healthy…

Neurons and Cognition · Quantitative Biology 2016-11-16 Amanmeet Garg , Donghuan Lu , Karteek Popuri , Mirza Faisal Beg

Topological data analysis (TDA) has become a powerful approach over the last twenty years, mainly due to its ability to capture the shape and the geometry inherent in the data. Persistence homology, which is a particular tool in TDA, has…

Neurons and Cognition · Quantitative Biology 2024-01-12 Anass B. El-Yaagoubi , Shuhao Jiao , Moo K. Chung , Hernando Ombao

Developing automated and semi-automated solutions for reconstructing wiring diagrams of the brain from electron micrographs is important for advancing the field of connectomics. While the ultimate goal is to generate a graph of neuron…

Computer Vision and Pattern Recognition · Computer Science 2016-08-09 William Gray Roncal , Colin Lea , Akira Baruah , Gregory D. Hager

Graphs are quickly emerging as a leading abstraction for the representation of data. One important application domain originates from an emerging discipline called "connectomics". Connectomics studies the brain as a graph; vertices…

The understanding of neural activity patterns is fundamentally linked to an understanding of how the brain's network architecture shapes dynamical processes. Established approaches rely mostly on deviations of a given network from certain…

Neurons and Cognition · Quantitative Biology 2014-09-19 Marc-Thorsten Huett , Marcus Kaiser , Claus C. Hilgetag

While statistical analysis of a single network has received a lot of attention in recent years, with a focus on social networks, analysis of a sample of networks presents its own challenges which require a different set of analytic tools.…

Methodology · Statistics 2019-10-23 Jesús D. Arroyo-Relión , Daniel Kessler , Elizaveta Levina , Stephan F. Taylor

Alzheimer's disease (AD) emerges from a complex interplay of molecular, cellular, and network-level disturbances that are not easily captured by traditional reductionist frameworks. Conventional analyses of gene expression often rely on…

Quantitative Methods · Quantitative Biology 2025-12-11 Aya Samadzelkava

Detecting statistical interactions between input features is a crucial and challenging task. Recent advances demonstrate that it is possible to extract learned interactions from trained neural networks. It has also been observed that, in…

Machine Learning · Computer Science 2020-11-05 Zirui Liu , Qingquan Song , Kaixiong Zhou , Ting Hsiang Wang , Ying Shan , Xia Hu

Brain structural connectivity, capturing the white matter fiber tracts among brain regions inferred by diffusion MRI (dMRI), provides a unique characterization of brain anatomical organization. One fundamental question to address with…

Neurons and Cognition · Quantitative Biology 2023-04-05 Selena Wang , Yiting Wang , Frederick H. Xu , Li Shen , Yize Zhao

Spontaneous brain activity, as observed in functional neuroimaging, has been shown to display reproducible structure that expresses brain architecture and carries markers of brain pathologies. An important view of modern neuroscience is…

Machine Learning · Statistics 2010-11-15 Gaël Varoquaux , Alexandre Gramfort , Jean Baptiste Poline , Bertrand Thirion

In this study, we performed comprehensive morphological investigations of the spontaneous formations of effective network structures among elements in coupled logistic maps, specifically with a delayed connection change. Our proposed model…

Adaptation and Self-Organizing Systems · Physics 2020-12-02 Amika Ohara , Masashi Fujii , Akinori Awazu

In increasingly many settings, data sets consist of multiple samples from a population of networks, with vertices aligned across these networks. For example, brain connectivity networks in neuroscience consist of measures of interaction…

Statistics Theory · Mathematics 2021-05-11 Keith Levin , Asad Lodhia , Elizaveta Levina

Autism Spectrum Disorder (ASD) is a prevalent neurological disorder. However, the multi-faceted symptoms and large individual differences among ASD patients are hindering the diagnosis process, which largely relies on subject descriptions…

Neurons and Cognition · Quantitative Biology 2024-11-11 Yuzhe Chen , Dayu Qin , Ercan Engin Kuruoglu

With the emergence of graph databases, the task of frequent subgraph discovery has been extensively addressed. Although the proposed approaches in the literature have made this task feasible, the number of discovered frequent subgraphs is…

Databases · Computer Science 2013-08-16 Wajdi Dhifli , Mohamed Moussaoui , Rabie Saidi , Engelbert Mephu Nguifo

Multi-modal neuroimaging technology has greatlly facilitated the efficiency and diagnosis accuracy, which provides complementary information in discovering objective disease biomarkers. Conventional deep learning methods, e.g. convolutional…

Image and Video Processing · Electrical Eng. & Systems 2022-10-26 Yanwu Yang , Xutao Guo , Zhikai Chang , Chenfei Ye , Yang Xiang , Ting Ma

Objective: In recent years, the functional connectivity of the human brain has been studied with graph theoretical tools. One such approach is community detection which is fundamental for uncovering the localized networks. Existing methods…

Signal Processing · Electrical Eng. & Systems 2022-09-27 Abdullah Karaaslanli , Meiby Ortiz-Bouza , Tamanna T. K. Munia , Selin Aviyente

The brain is a highly complex system. Most of such complexity stems from the intermingled connections between its parts, which give rise to rich dynamics and to the emergence of high-level cognitive functions. Disentangling the underlying…

Neurons and Cognition · Quantitative Biology 2023-08-14 Vito Dichio , Fabrizio De Vico Fallani
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