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Coherent Anti Stokes Raman Scattering (CARS) offers many advantages for nonlinear bio-imaging, thanks to its sub-cellular spatial resolution and unique chemical specificity. Its working principle requires two incident pulsed laser beams…

Nonlinear disordered media uniquely combine multiple scattering and second-harmonic generation. Here, we investigate the statistical properties of the nonlinear light generated within such media. We report super-Rayleigh statistics of the…

Light-based additive manufacturing holds great potential in the field of bioprinting due to its exceptional spatial resolution, enabling the reconstruction of intricate tissue structures. However, printing through biological tissues is…

We experimentally measure the monochromatic transmission matrix (TM) of an optical multiple scattering medium using a spatial light modulator together with a phase-shifting interferometry measurement method. The TM contains all information…

Optics · Physics 2015-05-28 S. M. Popoff , G. Lerosey , M. Fink , A. C. Boccara , S. Gigan

Ptychography has become prominent at synchrotron facilities worldwide for characterizing biological and material specimens' topological structures and properties at the nanometer or atomic scale, due to its lens - less, highly quantitative…

Image and Video Processing · Electrical Eng. & Systems 2025-01-28 Tao Liu , Bingyang Wang , JiangTao Zhao , Maik Kahnt , Fucai Zhang

The ability to detect and image short-wave infrared light has important applications in surveillance, autonomous navigation, and biological imaging. However, the current infrared imaging technologies often pose challenges due to their large…

The presence of a scattering medium in the imaging path between an object and an observer is known to severely limit the visual acuity of the imaging system. We present an approach to circumvent the deleterious effects of scattering, by…

Wavefront shaping makes it possible to form a focus through opaque scattering materials. In some cases, this focus may be scanned over a small distance using the optical memory effect. However, in many cases of interest, the optical memory…

Optics · Physics 2020-01-08 Bahareh Mastiani , Tzu-Lun Ohn , Ivo M. Vellekoop

Three-photon (3P) microscopy is getting traction due to its superior performance in deep tissues. Yet, aberrations and light scattering still pose one of the main limitations in the attainable depth ranges for high-resolution imaging. Here,…

Optical imaging through scattering media is a long-standing challenge. Although many approaches have been developed to focus light or image objects through scattering media, they are either invasive, restricted to stationary or…

Optics · Physics 2022-10-11 Xingchen Zhao , Xiaoyu Nie , Zhenhuan Yi , Tao Peng , Marlan O. Scully

The optical transmission matrix (TM) characterizes the transmission properties of a sample. We show a novel experimental procedure for measuring the TM of light waves in a slab geometry based on sampling the light field on a hexagonal…

Optics · Physics 2020-03-11 Pritam Pai , Jeroen Bosch , Allard P. Mosk

Ultrasound and radar signals are highly beneficial for medical imaging as they are non-invasive and non-ionizing. Traditional imaging techniques have limitations in terms of contrast and physical interpretation. Quantitative medical imaging…

Computer Vision and Pattern Recognition · Computer Science 2024-02-19 Tom Sharon , Yonina C. Eldar

Multimode optical fibres are hair-thin strands of glass that efficiently transport light. They promise next-generation medical endoscopes that provide unprecedented sub-cellular image resolution deep inside the body. However, confining…

Machine Learning · Computer Science 2024-06-13 Yijie Zheng , Robert J. Kilpatrick , David B. Phillips , George S. D. Gordon

Waves incident to a highly scattering medium are incapable of penetrating deep into the medium due to the diffusion process induced by multiple scattering. This poses a fundamental limitation to optically imaging, sensing, and manipulating…

In traditional spread-spectrum techniques, a wideband transmit signal is obtained by modulating a wideband carrier by a narrowband signal containing a relatively low-rate message. In the receiver, the respective demodulation/despreading…

Signal Processing · Electrical Eng. & Systems 2020-08-17 Alexei V. Nikitin , Ruslan L. Davidchack

We develop a method based on the cross-spectrum of an intensity-modulated CW laser, which can extract a signal from an extremely noisy environment and image objects hidden in turbid media. We theoretically analyzed our scheme and performed…

Precise light delivery through biological tissue is essential for deep-tissue imaging and phototherapeutic applications. Wavefront shaping enables control over scattered light by modulating the incident wavefront, but its application in…

Optics · Physics 2025-11-11 Xuan Liu , Sebastien Ourselin , Tianrui Zhao

The penetration depth of photoacoustic imaging in biological tissues has been fundamentally limited by the strong optical attenuation when light is delivered externally through the tissue surface. To address this issue, we previously…

Medical Physics · Physics 2021-02-24 Mucong Li , Tri Vu , Georgy Sankii , Brenton Winship , Kohldon Boydston , Russell Terry , Pei Zhong , Junjie Yao

Currently, diagnostic medicine uses a multitude of tools ranging from ionising radiation to histology analysis. With advances in piezoelectric crystal technology, high-frequency ultrasound imaging has developed to achieve comparatively high…

Medical Physics · Physics 2022-01-13 Akhil Kallepalli , James Halls , David B. James , Mark A. Richardson

Linear problems appear in a variety of disciplines and their application for the transmission matrix recovery is one of the most stimulating challenges in biomedical imaging. Its knowledge turns any random media into an optical tool that…

Machine Learning · Statistics 2019-02-05 Daniele Ancora , Luca Leuzzi