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X-ray computed tomography (CT) is widely used for medical diagnosis and treatment planning; however, concerns about ionizing radiation exposure drive efforts to optimize image quality at lower doses. This study introduces Poisson Flow…

Image and Video Processing · Electrical Eng. & Systems 2025-02-25 Dennis Hein , Grant Stevens , Adam Wang , Ge Wang

We introduce a dual-wavelength Fourier ptychographic topography (FPT) method that extends the lambda/2 height-range limit of single-wavelength FPT. By reconstructing complex fields at two illumination wavelengths and exploiting their phase…

One of the most prominent challenges in the field of diffractive imaging is the phase retrieval (PR) problem: In order to reconstruct an object from its diffraction pattern, the inverse Fourier transform must be computed. This is only…

Image and Video Processing · Electrical Eng. & Systems 2022-05-06 Simon Welker , Tal Peer , Henry N. Chapman , Timo Gerkmann

This paper introduces a sparse projection matrix composed of discrete (digital) periodic lines that create a pseudo-random (p.frac) sampling scheme. Our approach enables random Cartesian sampling whilst employing deterministic and…

Image and Video Processing · Electrical Eng. & Systems 2024-01-09 Marlon Bran Lorenzana , Benjamin Cottier , Matthew Marques , Andrew Kingston , Shekhar S. Chandra

Point-spread function (PSF) estimation in spatially undersampled images is challenging because large pixels average fine-scale spatial information. This is problematic when fine-resolution details are necessary, as in optimal photometry…

Instrumentation and Methods for Astrophysics · Physics 2021-02-03 Teresa Symons , Michael Zemcov , James Bock , Yun-Ting Cheng , Brendan Crill , Christopher Hirata , Stephanie Venuto

Filtered backprojection (FBP) is an efficient and popular class of tomographic image reconstruction methods. In photoacoustic tomography, these algorithms are based on theoretically exact analytic inversion formulas which results in…

Image and Video Processing · Electrical Eng. & Systems 2019-08-05 Johannes Schwab , Stephan Antholzer , Markus Haltmeier

Fluorescence molecular tomography (FMT) is a sensitive optical imaging technology widely used in biomedical research. However, the ill-posedness of the inverse problem poses a huge challenge to FMT reconstruction. Although end-to-end deep…

Image and Video Processing · Electrical Eng. & Systems 2025-03-18 Peng Zhang , Qianqian Xue , Xingyu Liu , Guanglei Zhang , Wenjian Wang , Jiye Liang

The problem of reconstruction of digital images from their degraded measurements is regarded as a problem of central importance in various fields of engineering and imaging sciences. In such cases, the degradation is typically caused by the…

Computer Vision and Pattern Recognition · Computer Science 2010-01-06 E. Shaked , O. Michailovich

We study an approach to solving the phase retrieval problem as it arises in a phase-less imaging modality known as ptychography. In ptychography, small overlapping sections of an unknown sample (or signal, say $x_0\in \mathbb{C}^d$) are…

Numerical Analysis · Mathematics 2019-10-09 Brian Preskitt , Rayan Saab

Fluorescence molecular tomography (FMT) has potential of providing high contrast images for breast tumor detection. Computational phantom provides a convenient way to a wide variety of fluorophore distribution configurations in patients and…

Medical Physics · Physics 2018-04-02 Yansong Zhu , Abhinav K. Jha , Arman Rahmim

The reconstruction fidelity of computational optical imaging is fundamentally constrained by the model-reality gap, i.e., the inevitable discrepancy between idealized forward models and the physical imaging process. Conventional paradigms…

Optics · Physics 2026-05-22 Sui-peng Wang , Si-yi Xie , Chang-tao Cai , Zhun Wei , Rui Chen

Photoacoustic microscopy (PAM) has been a promising biomedical imaging technology in recent years. However, the point-by-point scanning mechanism results in low-speed imaging, which limits the application of PAM. Reducing sampling density…

Image and Video Processing · Electrical Eng. & Systems 2020-06-09 Jiasheng Zhou , Da He , Xiaoyu Shang , Zhendong Guo , Sung-liang Chen , Jiajia Luo

Fluorescence microscopy (FM) imaging is a fundamental technique for observing live cell division, one of the most essential processes in the cycle of life and death. Observing 3D live cells requires scanning through the cell volume while…

Image and Video Processing · Electrical Eng. & Systems 2026-01-28 Chenwei Wang , Zhaoke Huang , Zelin Li , Wenqi Zhu

The limited dynamic range of the detector can impede coherent diffractive imaging (CDI) schemes from achieving diffraction-limited resolution. To overcome this limitation, a straightforward approach is to utilize high dynamic range (HDR)…

Image and Video Processing · Electrical Eng. & Systems 2024-06-11 Shantanu Kodgirwar , Lars Loetgering , Chang Liu , Aleena Joseph , Leona Licht , Daniel S. Penagos Molina , Wilhelm Eschen , Jan Rothhardt , Michael Habeck

Neurological Positron Emission Tomography (PET) is a critical imaging modality for diagnosing and studying neurodegenerative diseases like Alzheimer's disease. However, the inherent low spatial resolution of PET images poses significant…

Medical Physics · Physics 2025-02-24 Matthew Tivnan , Quanzheng Li

In this work we consider the problem of reconstruction of a signal from the magnitude of its Fourier transform, also known as phase retrieval. The problem arises in many areas of astronomy, crystallography, optics, and coherent diffraction…

Optics · Physics 2012-03-22 Eliyahu Osherovich

Ptychography is a popular microscopic imaging modality for many scientific discoveries and sets the record for highest image resolution. Unfortunately, the high image resolution for ptychographic reconstruction requires significant amount…

Image and Video Processing · Electrical Eng. & Systems 2022-12-19 Xiao Wang , Aristeidis Tsaris , Debangshu Mukherjee , Mohamed Wahib , Peng Chen , Mark Oxley , Olga Ovchinnikova , Jacob Hinkle

We study the problem of deconvolution for light-sheet microscopy, where the data is corrupted by spatially varying blur and a combination of Poisson and Gaussian noise. The spatial variation of the point spread function (PSF) of a…

The phase retrieval from multi-frequency intensity (power) observations is considered. The object to be reconstructed is complex-valued. A novel algorithm is presented that accomplishes both the object phase (absolute phase) retrieval and…

Signal Processing · Electrical Eng. & Systems 2018-02-07 Vladimir Katkovnik , Karen Egiazarian

Ptychography is an imaging technique which involves a sample being illuminated by a coherent, localized probe of illumination. When the probe interacts with the sample, the light is diffracted and a diffraction pattern is detected. Then the…

Numerical Analysis · Mathematics 2023-01-31 Mark Iwen , Michael Perlmutter , Mark Philip Roach
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