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Related papers: Elasticity of fibrous networks under axial prestre…

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Hydrogels of semiflexible biopolymers such as collagen have been shown to contract axially under shear strain, in contrast to the axial dilation observed for most elastic materials. Recent work has shown that this behavior can be understood…

Soft Condensed Matter · Physics 2019-05-13 Jordan Shivers , Jingchen Feng , Abhinav Sharma , Fred C. MacKintosh

Tissues commonly consist of cells embedded within a fibrous biopolymer network. Whereas cell-free reconstituted biopolymer networks typically soften under applied uniaxial compression, various tissues, including liver, brain, and fat, have…

Collagen is the main structural and load-bearing element of various connective tissues, where it forms the extracellular matrix that supports cells. It has long been known that collagenous tissues exhibit a highly nonlinear stress-strain…

Athermal models of disordered fibrous networks are highly useful for studying the mechanics of elastic networks composed of stiff biopolymers. The underlying network architecture is a key aspect that can affect the elastic properties of…

Soft Condensed Matter · Physics 2016-01-20 Albert James Licup , Abhinav Sharma , Fred C. MacKintosh

Disordered filamentous networks with compliant crosslinks exhibit a low linear elastic shear modulus at small strains, but stiffen dramatically at high strains. Experiments have shown that the elastic modulus can increase by up to three…

Biological Physics · Physics 2015-01-06 Knut M. Heidemann , Abhinav Sharma , Florian Rehfeldt , Christoph F. Schmidt , Max Wardetzky

Collagen is the most abundant extracellular-matrix protein in mammals and the main structural and load-bearing element of connective tissues. Collagen networks show remarkable strain-stiffening properties which tune the mechanical functions…

Soft Condensed Matter · Physics 2021-06-18 Swarnadeep Bakshi , Vaisakh VM , Ritwick Sarkar , Sayantan Majumdar

We study the mechanical stiffening behavior in two-dimensional (2D) cross-linked networks of semiflexible biopolymer filaments under simple shear. Filamental constituents immersed in a fluid undergo thermally excited bending motions.…

Biological Physics · Physics 2007-05-23 T. Van Dillen , P. R. Onck , E. Van der Giessen

Fibrous networks are ideal functional materials since they provide mechanical rigidity at low weight. Such structures are omnipresent in natural biomaterials from cells to tissues, as well as in man-made materials from polymeric composites…

Biopolymer networks are common in biological systems from the cytoskeleton of individual cells to collagen in the extracellular matrix. The mechanics of these systems under applied strain can be explained in some cases by a phase transition…

Soft Condensed Matter · Physics 2022-12-21 Sadjad Arzash , Abhinav Sharma , Fred C. MacKintosh

Filamentous bio-materials such as fibrin or collagen networks exhibit an enormous stiffening of their elastic moduli upon large deformations. This pronounced nonlinear behavior stems from a significant separation between the stiffnesses…

Soft Condensed Matter · Physics 2019-05-21 Robbie Rens , Carlos Villarroel , Gustavo Düring , Edan Lerner

Both animal and plant tissue exhibit a nonlinear rheological phenomenon known as compression stiffening, or an increase in moduli with increasing uniaxial compressive strain. Does such a phenomenon exist in single cells, which are the…

In this paper we study the elastic response of synthetic hydrogels to an applied shear stress. The hydrogels studied here have previously been shown to mimic the behaviour of biopolymer networks when they are sufficiently far above the gel…

Soft Condensed Matter · Physics 2016-05-05 M. Dennison , M. Jaspers , P. H. J. Kouwer , C. Storm , A. E. Rowan , F. C. MacKintosh

Biopolymer gels such as fibrin and collagen networks are known to develop tensile axial stress when subject to torsion. This negative normal stress is opposite to the classical Poynting effect observed for most elastic solids including…

Soft Condensed Matter · Physics 2018-04-04 Mahsa Vahabi , Bart E. Vos , Henri C. G. de Cagny , Daniel Bonn , Gijsje H. Koenderink , F. C. MacKintosh

Soft living tissues like cartilage can be considered as biphasic materials comprised of a fibrous complex biopolymer network and a viscous background liquid. Here, we show by a combination of experiment and theoretical analysis that both…

Soft Condensed Matter · Physics 2019-10-02 Melle T. J. J. M. Punter , Bart E. Vos , Bela M. Mulder , Gijsje H. Koenderink

When elastic solids are sheared, a nonlinear effect named after Poynting gives rise to normal stresses or changes in volume. We provide a novel relation between the Poynting effect and the microscopic Gr\"uneisen parameter, which quantifies…

Soft Condensed Matter · Physics 2018-04-16 Karsten Baumgarten , Brian P. Tighe

Soft biological tissues exhibit a remarkable resilience to large mechanical loads, a property which is associated with the strain stiffening capability of the biopolymer networks that structurally support the tissues. Yet, recent studies…

Soft Condensed Matter · Physics 2024-03-19 Jake Song , Elad Deiss-Yehiely , Serra Yesilata , Gareth H. McKinley

The mechanical properties of biological materials are spatially heterogeneous. Typical tissues are made up of a spanning fibrous extracellular matrix in which various inclusions, such as living cells, are embedded. While the influence of…

Soft Condensed Matter · Physics 2025-09-04 Jordan L. Shivers , Jingchen Feng , Fred C. MacKintosh

The collective action of actively contractile units embedded in elastic biopolymer networks plays a crucial role in regulating the network's macroscopic mechanical response. Here, we investigate how the macroscopic boundary stress in model…

Soft Condensed Matter · Physics 2026-03-25 Abhinav Kumar , David A. Quint , Kinjal Dasbiswas

We study the micromechanics of collagen-I gel with the goal of bridging the gap between theory and experiment in the study of biopolymer networks. Three-dimensional images of fluorescently labeled collagen are obtained by confocal…

Soft Condensed Matter · Physics 2009-09-29 Andrew M. Stein , David A. Vader , David A. Weitz , Leonard M. Sander

Disordered fiber networks exhibit a floppy to rigid mechanical phase transition as a function of connectivity. Sub-isostatically connected networks can undergo this transition via straining. Critical exponents governing this transition have…

Soft Condensed Matter · Physics 2026-03-31 Atharva Pandit , Fred C. MacKintosh , Abhinav Sharma
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